[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615361":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":120,"collaborators":124,"id":136,"slug":137,"hasResults":138,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":138,"sex":143,"minAge":144,"maxAge":10,"enrollmentInfo":145,"targetDuration":148,"studyType":149,"phases":10,"briefSummary":150,"conditions":151,"keywords":10,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},{"fullName":5,"class":6},"Azienda Ospedaliera \"Sant'Andrea\"","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"CCS patients with presence of micro- and nano-plastics (MNPs+)",null,"Consecutive patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication with the presence of micro- and nano-plastics (MNPs +).",{"label":13,"type":10,"description":14,"interventionNames":10},"CCS patients without the presence of micro- and nano-plastics (MNPs-)","Consecutive patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication without the presence of micro- and nano-plastics (MNPs -).",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Emanuele Barbato, MD, PhD","CONTACT","+39 0633776115","emanuele.barbato@uniroma1.it",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Clinical Research Unit Cardiology Dept. Sant'Andrea University Hospital","+39 0633778763","cru.cardiologia@uniroma1.it",[26,46,65,74,82,106],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Division of Cardiology, A.O.R.N. \"Sant'Anna e San Sebastiano\", Caserta, Italy.","NOT_YET_RECRUITING","Caserta","Italy","IT",{"type":33,"coordinates":34},"Point",[35,36],14.33231,41.07262,{"lat":36,"lon":35},[39,43],{"name":40,"role":18,"phone":41,"phoneExt":10,"email":42},"Paolo Calabrò, MD, Phd","+3908231783012","paolo.calabro@unicampania.it",{"name":44,"role":45,"phone":10,"phoneExt":10,"email":10},"Felice Gragnano, MD, PhD","SUB_INVESTIGATOR",{"facility":47,"status":28,"city":48,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.","Forlì",{"type":33,"coordinates":50},[51,52],12.04144,44.22177,{"lat":52,"lon":51},[55,59,61,63],{"name":56,"role":18,"phone":57,"phoneExt":10,"email":58},"Carmine Pizzi, MD, Phd","+39 051 2144933","carmine.pizzi@unibo.it",{"name":60,"role":45,"phone":10,"phoneExt":10,"email":10},"Luca Bergamaschi, MD, PhD",{"name":62,"role":45,"phone":10,"phoneExt":10,"email":10},"Matteo Armillotta, MD",{"name":64,"role":45,"phone":10,"phoneExt":10,"email":10},"Francesco Angeli, MD",{"facility":66,"status":67,"city":68,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":69,"geoPoint":73,"contacts":10},"Centro Cardiologico Monzino","ACTIVE_NOT_RECRUITING","Milan",{"type":33,"coordinates":70},[71,72],12.59836,42.78235,{"lat":72,"lon":71},{"facility":75,"status":67,"city":76,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":77,"geoPoint":81,"contacts":10},"Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.","Naples",{"type":33,"coordinates":78},[79,80],14.26811,40.85216,{"lat":80,"lon":79},{"facility":83,"status":84,"city":85,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Sant'Andrea University Hospital","RECRUITING","Roma",{"type":33,"coordinates":87},[88,89],11.10642,44.99364,{"lat":89,"lon":88},[92,95,98,100,102,104],{"name":93,"role":18,"phone":94,"phoneExt":10,"email":20},"Emanuele Barbato, MD, Phd","+390633776115",{"name":96,"role":18,"phone":97,"phoneExt":10,"email":24},"Clinical Research Unit","+390633778763",{"name":99,"role":45,"phone":10,"phoneExt":10,"email":10},"Pasquale Paolisso, MD, PhD",{"name":101,"role":45,"phone":10,"phoneExt":10,"email":10},"Marta Belmonte, MD, PhD",{"name":103,"role":45,"phone":10,"phoneExt":10,"email":10},"Emanuele Gallinoro, MD, PhD",{"name":105,"role":45,"phone":10,"phoneExt":10,"email":10},"Matteo Casenghi, MD, PhD",{"facility":107,"status":84,"city":108,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Azienda Ospedaliera Integrata Verona, Italy","Verona",{"type":33,"coordinates":110},[111,112],10.9938,45.43854,{"lat":112,"lon":111},[115,118],{"name":116,"role":18,"phone":10,"phoneExt":10,"email":117},"Flavio Ribichini, MD, Phd","flavio.ribichini@univr.it",{"name":119,"role":45,"phone":10,"phoneExt":10,"email":10},"Roberto Scarsini, MD, PhD",{"type":121,"investigatorFullName":122,"investigatorTitle":123,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Emanuele Barbato","Full Professor",[125,127,129,131,133],{"name":126,"class":6},"University of Campania Luigi Vanvitelli",{"name":128,"class":6},"Azienda Ospedaliera Universitaria Integrata Verona",{"name":130,"class":6},"Morgagni Pierantoni Hospital",{"name":132,"class":6},"Azienda Ospedaliera Sant'Anna e San Sebastiano",{"name":134,"class":135},"Centro Cardiologico Monzino, Milan, Italy","UNKNOWN","100615361","microplastics-and-nanoplastics-in-patients-with-chronic-coronary-syndromes-100615361",false,"NCT07291609","Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes","CCS-Plastics","Inclusion Criteria:\n\nALL the following:\n\n1. Age \\> 18 years old;\n2. Suspected or known chronic coronary syndromes undergoing coronary CT angiography;\n3. Clinical indication to invasive coronary angiography;\n4. Able to give informed consent.\n\nExclusion Criteria:\n\n1. Coronary CT angiography not available;\n2. Poor quality CCTA;\n3. Absence of native coronary stenosis \\>=50% at CCTA;\n4. Contraindications to invasive coronary angiography and percutaneous coronary intervention\n5. Life expectancy \\\u003C 1 year due to non-cardiac pathology","ALL","18 Years",{"count":146,"type":147},120,"ESTIMATED","3 Years","OBSERVATIONAL","The CCS-plastics is an investigator-initiated, prospective, multicenter study of patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication. Patients identified as eligible for the protocol will be asked for written consent to participate in the study. The patients' dossiers will be uploaded and transmitted to the core laboratory for analysis. The routine management of the CCS patients will not be affected and all patients will be managed according to current standards. Invasive coronary angiography and coronary blood samples will be performed following the current standards, guidelines, and indications. During invasive coronary angiography, coronary blood samples will be collected per standard of care and sent to a centralized, specialized core laboratory for MNPs and biomarkers analysis. The central core lab for MNPs analyses will be the University of Campania Luigi Vanvitelli, Naples, Italy. The identification, quantification (concentration, mcg\u002Fml), and typing of plastic particles will be performed in each tube for each patient, using pyrolysis-gas chromatography-mass spectrometry (Py-GC\u002FMS) and laser direct infrared (LDIR) spectroscopy. The CCTA will be centrally analyzed by Centro Cardiologico Monzino to evaluate qualitative and quantitative plaque features. Patients will be followed clinically at 1 and 3 years per standard of care.",[152,153,154,155,156,157,158],"Chronic Coronary Syndrome","Microplastics","Nanoplastics","Coronary Artery Disease","Coronary Plaque","Computed Tomography","Pollution Exposure","2026-06-06",{"date":161,"type":162},"2026-06-09","ACTUAL",{"date":164,"type":162},"2025-01-01",{"date":166,"type":147},"2029-12-31",{"name":5,"class":6},6]