[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630319":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":32,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":50,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients Undergoing Pancreatic Resection",null,"Patients undergoing elective pancreatic resection for benign or malignant pancreatic diseases at a single tertiary referral center. Biological samples, including pancreatic tissue (non-neoplastic and peri-neoplastic), peripancreatic adipose tissue, and peripheral blood, will be collected and analyzed to detect and characterize microplastics.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Sergio Alfieri, MD","CONTACT","+390530155133","sergio.alfieri@policlinicogemelli.it",[19],{"facility":20,"status":10,"city":21,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":10},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS di Roma","Rome","Lazio","00168","Italy","IT",{"type":27,"coordinates":28},"Point",[29,30],12.51133,41.89193,{"lat":30,"lon":29},{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","ALFIERI SERGIO","Professor of Surgery","100630319","microplastics-in-pancreas-oncologic-and-metabolic-impact-100630319",false,"NCT07486128","Microplastics in Pancreas: Oncologic and Metabolic Impact","Unveiling Microplastics in Human Pancreatic Tissue - Oncological and Metabolical Implications","PAN-Plastic","Inclusion Criteria:\n\nage between 18 and 80 years patients scheduled for elective pancreatic resection for benign or malignant pancreatic disease ability to understand and provide written informed consent no contraindications to general anesthesia\n\nExclusion Criteria:\n\nage \\\u003C18 or \\>80 years severe hepatic insufficiency (Child-Pugh class C) pregnancy or breastfeeding inability to understand the study procedures or provide informed consent","ALL","18 Years","80 Years",{"count":48,"type":49},10,"ESTIMATED","12 Months","OBSERVATIONAL","Microplastics and nanoplastics (MNPs) are emerging environmental contaminants that have been detected in several human tissues, raising concerns about their potential impact on human health. However, their presence in the human pancreas has not yet been investigated.\n\nThe aim of this prospective, single-center study is to detect and characterize microplastics in human pancreatic tissue obtained from patients undergoing pancreatic resection for benign or malignant diseases. Microplastics will also be analyzed in peripancreatic adipose tissue and peripheral blood. Advanced imaging techniques, including fluorescence microscopy, confocal microscopy, and Raman spectroscopy, will be used for identification and characterization.\n\nSecondary objectives include the evaluation of potential associations between microplastic burden and pancreatic metabolic function, assessed through clinical evaluation and metabolic testing. This proof-of-concept study aims to provide the first evidence of microplastic presence in the human pancreas and explore their potential role in metabolic dysfunction and carcinogenesis.",[54,55],"Pancreatic Diseases","Pancreatic Neoplasms",[57,54,55,58,59,60],"Microplastics","Glucose Metabolism","Raman Spectroscopy","Pancreatic Tissue","NOT_YET_RECRUITING","2026-03-24",{"date":64,"type":65},"2026-03-27","ACTUAL",{"date":67,"type":49},"2026-04-01",{"date":69,"type":49},"2027-04-01",{"name":5,"class":6},1]