[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469420":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"University of Utah","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Young",null,"Young healthy adult participants",{"label":13,"type":10,"description":14,"interventionNames":10},"Older","Older healthy adult participants",[16],{"name":17,"affiliation":18,"role":19},"Micah Drummond","The University of Utah","PRINCIPAL_INVESTIGATOR",[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Micah Drummond, PhD","CONTACT","801-213-2737","micah.drummond@hsc.utah.edu",[27],{"facility":18,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Salt Lake City","Utah","84112","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-111.89105,40.76078,{"lat":38,"lon":37},[41,42,43],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":10},{"name":10,"role":23,"phone":10,"phoneExt":10,"email":25},{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"type":19,"investigatorFullName":17,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Professor","100469420","microrna-regulation-of-chronic-inflammation-during-aging-100469420",false,"NCT05392582","MicroRNA Regulation of Chronic Inflammation During Aging","Inclusion Criteria:\n\n1. Age between 18 - 35y; 65y and older\n2. BMI: \\\u003C30 kg\u002Fm2\n3. Ability to sign informed consent\n4. For older participant group: Clinical Frailty Scale score \\\u003C 3 and Mini-Cog score \\> 3\n5. Good general medical health, ambulatory and in independent living setting\n\nExclusion Criteria:\n\n* History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)\n* History of endocrine or metabolic disease such as hypo\u002Fhyperthyroidism and diabetes (Treated hypo\u002Fhyperthyroid for at least 6 months will be permitted)\n* History of kidney disease or failure (CKD \\> stage 4)\n* History of vascular disease\n* Uncontrolled hypertension - Elevated systolic pressure \\>150 or a diastolic blood pressure \\> 100\n* Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma\n* Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular\u002Ftopical\u002Finhaled therapeutic or physiologic doses of corticosteroids will be permitted)\n* Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment\n* Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C\n* History of stroke with motor disability\n* A recent history (\\\u003C12 months) of GI bleed\n* History of liver disease or AST\u002FALT 2 times above the normal limit\n* History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)\n* Current smokers or current tobacco use\n* Current pregnancy as determined by positive pregnancy test\n* Any staff members who report directly to the principal investigators.",true,"ALL","18 Years",{"count":56,"type":57},40,"ESTIMATED","OBSERVATIONAL","This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation.\n\nThe enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \\& exercise tests.",[61],"Chronic Inflammation","2025-12-01",{"date":64,"type":65},"2025-12-05","ACTUAL",{"date":67,"type":65},"2024-11-12",{"date":69,"type":57},"2028-01-01",{"name":5,"class":6},1]