[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635223":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":24,"locations":23,"responsibleParty":30,"collaborators":32,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":37,"sex":43,"minAge":44,"maxAge":23,"enrollmentInfo":45,"targetDuration":23,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":58,"whyStopped":23,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":23},{"fullName":5,"class":6},"University College, London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Burr-Hole Evacuation With CT-Guided Intra-Operative MMA Interruption","EXPERIMENTAL","Participants in this single-arm feasibility study will undergo standard burr-hole evacuation of chronic subdural haematoma with subdural drain placement, in accordance with routine clinical practice. In addition, a CT- and neuronavigation-guided intra-operative adjunct will be attempted to identify and interrupt distal convexity branches of the middle meningeal artery (MMA) supplying the haematoma membrane, where this is considered safe and technically feasible by the operating surgeon.\n\nThe adjunct involves minor adjustment of burr-hole position within the haematoma footprint and limited bipolar coagulation of target MMA branches. If safe identification or access is not possible, the adjunct will be omitted and standard surgery completed.\n\nAll imaging and peri-operative care are part of standard clinical practice. The study is designed to assess feasibility, safety, procedural fidelity and workflow integration rather than clinical effectiveness.",[13],"Procedure: CT-Guided Intra-Operative Middle Meningeal Artery Interruption",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","CT-Guided Intra-Operative Middle Meningeal Artery Interruption","This intervention is a surgical adjunct performed during standard burr-hole evacuation of chronic subdural haematoma. Using pre-operative non-contrast CT and intra-operative neuronavigation, the surgeon identifies distal convexity branches of the middle meningeal artery (MMA) supplying the haematoma membrane. Where safely accessible, limited bipolar coagulation is applied to interrupt these branches through the planned burr-hole. Burr-hole position may be slightly adjusted within the haematoma footprint to facilitate safe targeting. If branches cannot be confidently identified or safely accessed, the adjunct is omitted and standard surgery is completed. No additional imaging or devices are introduced beyond routine clinical care.",[9],[21,22],"MMA coagulation during burr-hole surgery","Intra-operative MMA interruption",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Jigishaa Moudgil-Joshi, MRCS, MBChB","CONTACT","020 3456 7890","burrmmatrial@gmail.com",{"type":31,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[33],{"name":34,"class":6},"University College London Hospitals","100635223","middle-meningeal-artery-coagulation-during-burr-hole-drainage-for-chronic-subdural-haematoma-burr-mma-100635223",false,"NCT07549893","Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)","BURR-MMA: A Prospective Pilot Feasibility Study of Intra-operative Middle Meningeal Artery Coagulation During Burr-Hole Surgery for Chronic Subdural Haematoma","BURR-MMA","Inclusion Criteria:\n\n* Age ≥18 years.\n* Chronic or subacute subdural haematoma scheduled for burr-hole evacuation.\n* Treating surgeon considers the CT- and navigation-guided MMA adjunct technically feasible and safe to attempt, recognising that the adjunct may be abandoned intra-operatively according to protocol bail-out criteria.\n* Written informed consent, or consultee declaration under the Mental Capacity Act (MCA), with re-consent if capacity returns.\n\nConsented participants who meet eligibility criteria will be enrolled sequentially until the target sample size of 20-30 participants is reached. No randomisation is used in this feasibility phase.\n\nExclusion Criteria:\n\n* Acute subdural haematoma requiring craniotomy or decompressive surgery.\n* Prior ipsilateral MMA embolisation.\n* Clear contraindication to pre-operative CT\n* Inability to complete Day-90 follow-up.\n* Pregnancy or breastfeeding (due to radiation exposure from CT imaging as part of standard clinical care).\n\nIf CT is non-diagnostic or cannot be performed, participants will continue with standard burr-hole evacuation without the MMA adjunct; this does not constitute a protocol deviation.","ALL","18 Years",{"count":46,"type":47},30,"ESTIMATED","INTERVENTIONAL",[50],"NA","Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection. Even with good surgery, around 1 in 10 patients develop a recurrence and need a second operation. Research shows that the outer lining of the haematoma is fed by small branches of the middle meningeal artery (MMA), and interrupting these branches may lower the risk of recurrence.\n\nThis study looks at whether surgeons can safely and reliably coagulate these small MMA branches at the same time as standard burr-hole drainage, using the routine pre-operative CT scan and surgical navigation already used in everyday practice. Adults (aged 18 years and over) scheduled for burr-hole drainage of a chronic or subacute subdural haematoma will be invited to take part. The procedure, recovery, drain management, and 90-day follow-up will otherwise follow standard NHS care.\n\nNo additional imaging is required for the study, and participants are not exposed to any extra radiation. The main purpose is feasibility and safety, not to prove effectiveness. Findings will inform the design of a future multicentre study.",[53],"Chronic Subdural Hematomas",[55,56,57],"chronic subdural haematoma","middle meningeal artery","burrholes","NOT_YET_RECRUITING","2026-04-17",{"date":61,"type":62},"2026-04-24","ACTUAL",{"date":64,"type":47},"2026-08-01",{"date":66,"type":47},"2027-12-01",{"name":5,"class":6}]