[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591434":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":123,"collaborators":125,"id":135,"slug":136,"hasResults":137,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":26,"eligibilityCriteria":141,"healthyVolunteers":142,"sex":143,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":26,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},{"fullName":5,"class":6},"a2 Milk Company Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"a2 UHT Milk","ACTIVE_COMPARATOR","containing A2 type β-casein only (A1PF)",[13],"Other: a2 UHT milk",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional UHT milk","PLACEBO_COMPARATOR","containing both A1 and A2 type β-caseins (CON)",[19],"Other: Conventional UHT Milk",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"OTHER","a2 UHT milk","Pregnant women in this arm will drink a2 UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional UHT Milk","Pregnant women in this arm will drink conventional UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Fen Xie","CONTACT","86 510 88682959","jndxfygcp@163.com",[38,57,71,86,94,108],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Foshan Maternity & Child Healthcare Hospital","RECRUITING","Foshan","Guangdong","528000","China","CN",{"type":47,"coordinates":48},"Point",[49,50],113.13148,23.02677,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":55,"phoneExt":26,"email":56},"Yao Fu","+86-757-22978072","124166604@qq.com",{"facility":58,"status":40,"city":59,"state":42,"zip":60,"country":44,"countryCode":45,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Panyu Maternal and Child Care Service Centre of Guangzhou","Guangzhou","511400",{"type":47,"coordinates":62},[63,64],113.25,23.11667,{"lat":64,"lon":63},[67],{"name":68,"role":34,"phone":69,"phoneExt":26,"email":70},"Guoliang He","+86 20 3915 9963","pyfygcp@163.com",{"facility":72,"status":40,"city":73,"state":74,"zip":75,"country":44,"countryCode":45,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Wuxi Maternal and Child Health Hospital","Wuxi","Jiangsu","214002",{"type":47,"coordinates":77},[78,79],120.28857,31.56887,{"lat":79,"lon":78},[82],{"name":83,"role":34,"phone":84,"phoneExt":26,"email":85},"Yan Sun","+86-510-68004318","wxfuyou@126.com",{"facility":87,"status":40,"city":73,"state":74,"zip":88,"country":44,"countryCode":45,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"Affiliated hospital of Jiangnan University","214122",{"type":47,"coordinates":90},[78,79],{"lat":79,"lon":78},[93],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"facility":95,"status":40,"city":96,"state":74,"zip":97,"country":44,"countryCode":45,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Xuzhou Maternal and Child Health Hospital","Xuzhou","221009",{"type":47,"coordinates":99},[100,101],117.28386,34.20442,{"lat":101,"lon":100},[104],{"name":105,"role":34,"phone":106,"phoneExt":26,"email":107},"Shuai Zhao","+85 516 8390 7537","xfirb@163.com",{"facility":109,"status":40,"city":110,"state":111,"zip":112,"country":44,"countryCode":45,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"First People's Hospital of Chengdu","Chengdu","Sichuan","610041",{"type":47,"coordinates":114},[115,116],104.06667,30.66667,{"lat":116,"lon":115},[119],{"name":120,"role":34,"phone":121,"phoneExt":26,"email":122},"Juan Zhou","+86 28 85223984","cdsyyyll@163.com",{"type":124,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[126,129,131,133],{"name":127,"class":128},"Edanz Inc","UNKNOWN",{"name":130,"class":128},"Cyanth (Wuxi) Health Technology Co. Ltd.",{"name":132,"class":128},"Affilicated Hospital of Jiangnan University",{"name":134,"class":128},"Guangzhou Trials Medical","100591434","milk-free-from-a1-type--casein-on-inflammation-gastrointestinal-tolerance-and-pregnancy-outcomes-100591434",false,"NCT06980376","Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes","Effects of Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes: A Multi-Centre, Randomised, Open-Label, Prospective Study","Inclusion Criteria:\n\n* 20-35 years of age\n* Recruited at \\\u003C12 weeks of gestation\n* Intention to deliver at study site hospital\n* Singleton pregnancy\n* Able and willing to consume milk during pregnancy\n* Agree not to participate in another interventional clinical study during the present study\n\nExclusion Criteria:\n\n* Body mass index ≥ 35 at enrolment\n* Cow's milk intolerance or allergy\n* Significant systemic disorder (e.g., cardiac, respiratory, endocrinological, hemato-logic, or GI); pre-pregnancy diabetes, hypertension, or other medical conditions that preclude participation per the investigator's judgement\n* Taking any prescribed chronic medications\n* Participation in another clinical trial\n* Investigator uncertainty about the willingness or ability of the participant to comply with the protocol requirements\n* Taking probiotics at screening or two weeks before enrolment\n* Receiving any vaccine at screening or two weeks before enrolment",true,"FEMALE","20 Years","35 Years",{"count":147,"type":148},100,"ESTIMATED","INTERVENTIONAL",[151],"NA","The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance, and GI symptoms in pregnant women as well as infants' birth outcomes from 12 weeks' gestation up to 40 days post-birth.",[154],"Healthy Pregnant Women","2026-02-04",{"date":157,"type":158},"2026-02-06","ACTUAL",{"date":160,"type":158},"2025-08-25",{"date":162,"type":148},"2026-09",{"name":5,"class":6},6]