[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587619":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":44,"locations":50,"responsibleParty":65,"collaborators":32,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":32,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":32,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":32,"overallStatus":88,"whyStopped":32,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Nanjing Mingzhou Rehabilitation Hospital","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"MDT group","EXPERIMENTAL","Mindfulness-enhanced Dual-task Training",[13,14],"Device: Cognitive-Motor Dual-Task Training","Other: Mindfulness Training",{"label":16,"type":17,"description":18,"interventionNames":19},"DT group","ACTIVE_COMPARATOR","Dual-task Training",[13,20],"Other: Quiet Rest",{"label":22,"type":17,"description":23,"interventionNames":24},"ST group","Single-task Training",[25,20],"Device: Single-task Training",[27,33,37,40],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Cognitive-Motor Dual-Task Training","Participants perform physical exercises using the balance training system and isokinetic muscle strength training system while simultaneously completing cognitive tasks to improve motor-cognitive coordination. The training follows a task-segmentation approach:\n\nBalance Task Module: Participants perform dynamic balance training on the balance training system while engaging in cognitive tasks (e.g., digit span, arithmetic, or word fluency tasks).\n\nStrength Task Module: Participants conduct isokinetic strength training while performing corresponding cognitive tasks.\n\nTask difficulty is progressively adjusted based on participant performance.",[16,9],null,{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Mindfulness Training","Guided by a professional mindfulness instructor, participants engage in mindfulness meditation to enhance attention, emotional regulation, and cognitive readiness. The training includes breath awareness, body scan, and present-moment awareness, delivered through guided meditation.",[9],{"type":28,"name":23,"description":38,"armGroupLabels":39,"otherNames":32},"Participants perform physical exercises using the balance training system and isokinetic muscle strength training system without any concurrent cognitive tasks. The training follows a task-segmentation approach, including dynamic balance training and isokinetic strength training to enhance motor function.",[22],{"type":6,"name":41,"description":42,"armGroupLabels":43,"otherNames":32},"Quiet Rest","Participants remain seated in a quiet environment without engaging in mindfulness training or cognitive tasks.",[16,22],[45],{"name":46,"role":47,"phone":48,"phoneExt":32,"email":49},"Jingzhi Zhang","CONTACT","+86-16677137704","170787717@qq.com",[51],{"facility":5,"status":32,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Nanjing","Jiangsu","210046","China","CN",{"type":58,"coordinates":59},"Point",[60,61],118.77778,32.06167,{"lat":61,"lon":60},[64],{"name":46,"role":47,"phone":48,"phoneExt":32,"email":49},{"type":66,"investigatorFullName":46,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","technician in charge","100587619","mindfulness-enhanced-dual-task-training-in-pd-mci-100587619",false,"NCT06930742","Mindfulness-Enhanced Dual-Task Training in PD-MCI","Mindfulness-Enhanced Cognitive-Motor Dual-Task Training Using Balance and Isokinetic Systems for Parkinson's Disease With Mild Cognitive Impairment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age: Between 55 and 75 years.\n* Disease Diagnosis: Clinically diagnosed with Idiopathic Parkinson's Disease (PD) according to the UK Parkinson's Disease Society Brain Bank Criteria.\n* Disease Stage: Hoehn \\& Yahr (H\\&Y) stages 1 to 2.5.\n* Cognitive Function: Montreal Cognitive Assessment (MoCA) score between 23 and 26, indicating mild cognitive impairment (MCI).\n* Medication Stability: Stable doses of antiparkinsonian medications for at least 4 weeks prior to screening.\n* Subjective Cognitive Complaints: Self-reported or informant-reported cognitive decline persisting for at least 6 months.\n* Ambulatory Ability: Able to walk independently, with or without assistive devices.\n* Sensory Abilities: Adequate vision and hearing to comply with study procedures.\n* Informed Consent: Willingness to provide written informed consent and comply with study requirements.\n\nExclusion Criteria:\n\n* Other Neurological Disorders: Presence of other neurological conditions that could affect cognitive function, such as Alzheimer's disease, stroke, or brain tumors.\n* Psychiatric Conditions: Severe psychiatric disorders, including major depressive disorder or schizophrenia.\n* Substance Abuse: Recent history of drug or alcohol abuse.\n* Serious Medical Conditions: Uncontrolled hypertension, diabetes, heart disease, or other conditions that could interfere with study participation or outcomes.\n* Severe Cognitive Impairment: Diagnosis of Parkinson's Disease Dementia (PDD).\n* Other Factors Affecting Cognition: Recent head trauma, uncontrolled thyroid dysfunction, vitamin B12 deficiency, or other conditions known to affect cognitive function.\n* Deep Brain Stimulation (DBS): History of DBS treatment. Participation in Other Clinical Trials: Participation in another clinical trial that could interfere with this study within the last 3 months.","ALL","55 Years","75 Years",{"count":79,"type":80},90,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to learn if Mindfulness-Enhanced Dual-Task Training work to treat PD-MCI in adults. The main questions it aims to answer are:\n\nDoes Mindfulness-Enhanced Dual-Task Training improve the cognitive or motor function of participants? Can the combination of Dual-Task Training and Mindfulness achieve better effects?\n\nResearchers will compare 3 groups (Dual-Task Training + Mindfulness, Dual-Task Training, and conventional motor task training) to see if Dual-Task Training and Mindfulness works to treat PD-MCI.\n\nParticipants will:\n\nReceive treatment for 4 weeks Receive scale and instrument testing before and after treatment",[86,87],"Mild Cognitive Impairment (MCI)","Parkinson's Disease (PD)","NOT_YET_RECRUITING","2025-04-09",{"date":91,"type":92},"2025-04-16","ACTUAL",{"date":94,"type":80},"2025-05-01",{"date":96,"type":80},"2025-07-30",{"name":5,"class":6},1]