[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621356":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":11,"locations":24,"responsibleParty":51,"collaborators":54,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":11,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":27,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Mindfulness Training during aiTBS","EXPERIMENTAL",null,[13],"Behavioral: Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"BEHAVIORAL","Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app","5-15 minutes of mindfulness exercises during aiTBS inter-session intervals (9 total per day) for five consecutive treatment days; optional additional practices allowed. App analytics (with permission) and self-reports quantify engagement.",[9],[21],{"name":22,"affiliation":5,"role":23},"Clayton Olash, MD","PRINCIPAL_INVESTIGATOR",[25,45],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"IOP","RECRUITING","Charleston","South Carolina","29407","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-79.93275,32.77632,{"lat":37,"lon":36},[40],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Danyal Smani, MD","CONTACT","1 843 243 7306","claytonolash@gmail.com",{"facility":46,"status":47,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":48,"geoPoint":50,"contacts":11},"Medical University of South Carolina (MUSC), Brain Stimulation Laboratory Institute of Psychiatry","NOT_YET_RECRUITING",{"type":34,"coordinates":49},[36,37],{"lat":37,"lon":36},{"type":23,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Clayton Olash","Medical\u002FDental Resident",[55,57],{"name":56,"class":6},"University of Wisconsin, Madison",{"name":58,"class":59},"National Institute on Drug Abuse (NIDA)","NIH","100621356","mindfulness-training-during-accelerated-tms-for-depression-100621356",false,"NCT07369557","Mindfulness Training During Accelerated TMS for Depression","MB-TBS: Mindfulness-Based Theta-Burst Stimulation-A Pilot Study Integrating Mindfulness Training Into Accelerated Neuromodulation Therapy for Depression","Inclusion Criteria:\n\n* Clinical diagnosis of MDD and eligible for aiTBS at MUSC\n* Already enrolled in aiTBS course at MUSC\n* English proficiency\n* Smartphone or willingness to use study-provided device\n\nExclusion Criteria:\n\n* TMS contraindications (e.g., seizure history, implants, pregnancy)\n* Concurrent neuromodulation (ECT, VNS)\n* Psychotic disorder, bipolar disorder, active substance use disorder, high suicide risk\n* Unable\u002Funwilling to engage in mindfulness or complete questionnaires","ALL","18 Years","80 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility\u002Facceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.",[78],"Depression",[80,81,82,83,84,85],"Major Depressive Disorder","Transcranial Magnetic Stimulation","Theta-Burst Stimulation","Mindfulness","Positive Affect","Hedonic Tone","2026-06-16",{"date":88,"type":89},"2026-06-17","ACTUAL",{"date":91,"type":89},"2026-04-13",{"date":93,"type":72},"2026-10-30",{"name":5,"class":6},2]