[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100434270":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Humanitas Clinical and Research Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention _mini_FC",null,"The fluid challenge consists of 4 ml\\*Kg of Crystalloids' solution infused over 10 minutes, administered via either a central or a peripheral line.\n\n1. The patient is already connected to the PICCO monitoring for clinical purpose of hemodynamic monitoring (before study enrollment)\n2. The MOSTCARE system is connected to the MONITOR of the patient (and not to the patient itself) by means of a cable inserted into the connections system.\n3. The echocardiography will be performed by a senior intensivist\u002Fcardiologist. The stroke volume is calculated by measuring VTI and diameter at the same point. This is best performed by measuring the diameter of the LVOT in the parasternal long axis (PLAX) view",[13],"Diagnostic Test: mini_FC",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","mini_FC","100 ml of Crystalloids infused over 1 minute - data recording and new baseline - FC 4 ml\u002Fkg in 10 minutes - data recording",[9],[21,43],{"facility":22,"status":10,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Humanitas Research Hospital","Rozzano","MILANO","20089","Italy","IT",{"type":29,"coordinates":30},"Point",[31,32],9.1559,45.38193,{"lat":32,"lon":31},[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Antonio Messina, MD","CONTACT","+390282241","antonio.messina@humanitas.it",{"name":36,"role":37,"phone":41,"phoneExt":10,"email":42},"+3902822414131","mess81rc@gmail.com",{"facility":44,"status":10,"city":45,"state":45,"zip":46,"country":26,"countryCode":27,"cosmosGeoPoint":47,"geoPoint":51,"contacts":10},"Antonio Messina","Novara","28100",{"type":29,"coordinates":48},[49,50],8.62118,45.44694,{"lat":50,"lon":49},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100434270","mini-fluid-challenge-assessment-a-comparison-among-three-hemodynamic-tools-100434270",false,"NCT04934943","\"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools\"","MINI3","Inclusion criteria\n\n1\\) Acute circulatory failure defined as:\n\n* SAP ≤ 90 mmHg (or a decrease \\> 50 mm Hg in hypertensive patients)\n* or a mean arterial pressure (MAP) ≤ 70 mmHg\n* or the use of vasopressors to maintain SAP \\>90 mmHg,\n* associated with skin mottling; tachycardia ≥100 beats\u002Fmin; urinary flow ≤0.5 mL\u002Fkg for at least 2 hours; blood lactate level ≥4 mmol\u002FL.\n\nExclusion criteria:\n\n* known severe myocardial or valvular dysfunction\n* cardiac arrhythmias\n* severe acute respiratory distress syndrome\n* on-going haemodialysis or continuous hemofiltration\n* moribund patients\n* persistent low quality of the arterial signal affecting hemodynamic monitoring measurements\n* poor echographic windows.","ALL","18 Years",{"count":64,"type":65},45,"ESTIMATED","OBSERVATIONAL","The mini fluid challenge (mini\\_FC) is a functional hemodynamic test which has been used in different clinical contexts to assess fluid responsiveness.\n\nThis test is performed by rapidly injecting a small aliquot of fluid (100 ml over 1 minute), which is followed by the infusion of the residual aliquot of fluid.\n\nSince the threshold of the mini\\_FC identified by the literature is rather small (5% of stroke volume (SV) increase after the 100 ml bolus to discriminate between responder and non-responder), it is crucial that the hemodynamic tool assessing this change could be reliable. Moreover, the SV changes with inspiratory\u002Fexpiratory movements and the increase after the mini\\_FC should also consider the physiological fluctuations of the SV.\n\nIn the literature this test has been performed by means of tolls with different least significant change of the SV. The least significant change (LSC) represents the smallest difference between successive measurements of SV that can be considered to be a real change and not attributable to chance.\n\nThe purpose of this study is to assess the agreement among MOSTCARE system (4.5\\& of SV LSC described in the literature) and the echocardiography (about 10% of SV LSC described in the literature) with the PICCO system (about 1% of SV LSC described in the literature - considered the gold standard) in discriminating fluid responsiveness after a mini\\_FC",[69,70,71],"Sepsis","Shock, Septic","Critically Ill",[73,74],"Fluid challenge","Functional hemodynamic test","NOT_YET_RECRUITING","2025-06-25",{"date":78,"type":79},"2025-06-29","ACTUAL",{"date":81,"type":65},"2025-08-01",{"date":81,"type":65},{"name":5,"class":6},2]