[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601945":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":40,"centralContacts":48,"locations":30,"responsibleParty":57,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":30,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":30,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":89,"whyStopped":30,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":30},{"fullName":5,"class":6},"University of Turku","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-smokers cNSPT","ACTIVE_COMPARATOR","Participants will be non-smokers. Periodontal treatment intervention will include: thorough debridement of the root surface under local anaesthesia, using conventional piezoelectric devices (EMS, Switzerland) and hand instruments (Gracey, Hu Friedy).",[13],"Procedure: conventional Non-Surgical Periodontal Treatment (cNSPT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-smokers MINST","EXPERIMENTAL","Participants will be non-smokers. Periodontal treatment intervention will include: local anaesthesia by infiltration without adrenaline, thorough debridement of the root surface through a subpapillary access using exclusively piezoelectric devices with specific thin and delicate tips (EMS, Switzerland) and 4X magnification loupes, taking care to minimize the soft tissue trauma and to stimulate the formation of a stable blood clot.",[19],"Procedure: Minimally Invasive Non- Surgical Periodontal Therapy (MINST)",{"label":21,"type":16,"description":22,"interventionNames":23},"Smokers MINST","Participants will be smokers. Periodontal treatment intervention will include: local anaesthesia by infiltration without adrenaline, thorough debridement of the root surface through a subpapillary access using exclusively piezoelectric devices with specific thin and delicate tips (EMS, Switzerland) and 4X magnification loupes, taking care to minimize the soft tissue trauma and to stimulate the formation of a stable blood clot.",[19],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Minimally Invasive Non- Surgical Periodontal Therapy (MINST)","The procedure consists of thorough debridement of the root surface through a subpapillary access using exclusively piezoelectric devices with specific thin and delicate tips (EMS, Switzerland) and 4X magnification loupes, taking care to minimize the soft tissue trauma and to stimulate the formation of a stable blood clot",[15,21],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"conventional Non-Surgical Periodontal Treatment (cNSPT)","The intervention consists of thorough debridement of the root surface under local anaesthesia, using conventional piezoelectric devices and hand instruments",[9],[36,37,38,39],"scaling and root planing","SRP","non-surgical periodontal treatment","periodontal debridement",[41,45],{"name":42,"affiliation":43,"role":44},"ILIAS OIKONOMOU, DDS,MSc","Institute of Dentistry, University of Turku, Turku, Finland","PRINCIPAL_INVESTIGATOR",{"name":46,"affiliation":43,"role":47},"Ulvi Gürsoy, DDS, PhD","STUDY_DIRECTOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":30,"email":53},"ILIAS OIKONOMOU, DDS, MSc","CONTACT","+306906522601","oikonomou.perioortho@gmail.com",{"name":46,"role":51,"phone":55,"phoneExt":30,"email":56},"+358 50 514 8132","ulvi.gursoy@utu.fi",{"type":44,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"ILIAS OIKONOMOU","Principal Investigator, Periodontist, Department of Periodontology, 251 Hellenic Air Force & VA Hospital, Athens, Greece, Doctoral researcher, Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland",[61],{"name":62,"class":6},"251 Hellenic Air Force & VA General Hospital","100601945","minimally-invasive-non--surgical-periodontal-therapy-of-intrabony-defects-healing-patterns-and-smoking-impact-100601945",false,"NCT07117097","Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Healing Patterns and Smoking Impact","Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Molecular Healing Patterns and the Impact of Smoking on Outcomes","Inclusion Criteria:\n\n* patients with Periodontitis stage III or IV, grades B to C . Each patient will have to present one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\>3mm).\n* participants should be free of any systemic or oral conditions that could affect disease progression or treatment outcomes\n\nExclusion Criteria:\n\n* diabetes\n* hepatic or renal disease\n* history of conditions requiring prophylactic antibiotics\n* anti-inflammatory or anticoagulant therapy the preceding month\n* systemic antibiotic therapy the preceding 3 months\n* history of alcohol or drug abuse\n* self-reported pregnancy or lactation\n* other severe acute or chronic medical or psychiatric condition\n* periodontal treatment within the last 12 months\n* presence of drug-induced gingival overgrowth","ALL","18 Years","80 Years",{"count":74,"type":75},120,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study is consisted of two arms. At first, a randomized controlled clinical trial will be conducted. Eighty systematically healthy, non-smoker patients with Periodontitis stage III or IV, grades B to C will be included. Each patient will have to present one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\> or =3mm). The patients will be randomized in two groups, regarding the treatment intervention of the intrabony defects: Group A (conventional Non-Surgical Periodontal Treatment, cNSPT) and Group B (Minimally Invasive Non-Surgical Therapy, MINST). At 5 days and 3 months following intervention, GCF samples will be collected from the intrabony defects in order to assess the molecular healing patterns through intergroup comparisons of inflammation and healing biomarkers. Then two prospective cohort studies will be conducted. The Group B patients will be matched with forty systematically healthy, smoker patients (Group C) with Periodontitis stage III or IV, grades B to C with each one presenting one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\> or =3mm). Then MINST will be performed in the patients of Group C and the two groups will be compared regarding the clinical and radiographic data obtained by clinical and radiographic examinations performed in both groups' intrabony defects pre-treatment and 6 months following the intervention (first prospective study) and regarding the differences in regeneration biomarkers in GCF samples obtained from the intrabony defects 5 days and 3 months post-treatment (second prospective study).",[81],"Periodontitis",[81,83,84,85,86,87,88],"Intrabony defect","GCF","Minimally invasive","smoking","non surgical","bone","NOT_YET_RECRUITING","2025-08-13",{"date":92,"type":93},"2025-08-19","ACTUAL",{"date":95,"type":75},"2025-09",{"date":97,"type":75},"2027-04",{"name":5,"class":6}]