[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628847":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":33,"locations":39,"responsibleParty":64,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":32,"enrollmentInfo":80,"targetDuration":32,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":42,"whyStopped":32,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"St. Anne's University Hospital Brno, Czech Republic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Non-Surgical Peri-implant Therapy (NSPT)","EXPERIMENTAL","* Ultrasonic debridement with stainless steel tips\n* Steel curettes (Columbia 4R\u002F4L)\n* Submucosal curettage\n* Local anesthesia",[13],"Procedure: Non-Surgical Peri-implant Therapy (NSPT)",{"label":15,"type":10,"description":16,"interventionNames":17},"Minimally-Invasive Non-Surgical Therapy (MINST)","* Exclusive use of thin, non-diamond ultrasonic tips (PS, PL1, PL2, Siroperio, Woodpecker P3, Acteon 10Z)\n* ≥3× magnification\n* Aim to obtain stable blood clot formation",[18],"Procedure: Minimally-Invasive Non-Surgical Therapy (MINST)",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Non-Surgical Peri-implant Therapy (NSPT)","Standard mechanical debridement of the peri-implant pocket performed under local anesthesia. Treatment includes supra- and submucosal ultrasonic debridement using stainless-steel ultrasonic tips, followed by mechanical curettage of granulation tissue with steel curettes (Columbia 4R\u002F4L). Soft-tissue curettage is performed from the inner aspect of the peri-implant pocket. No time restriction is imposed; the operator works until the implant surface is clinically clean.",[9],[26],"NSPT",{"type":21,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Minimally invasive ultrasonic debridement performed under local anesthesia using exclusively thin, non-diamond ultrasonic tips (Satalec PS3, EMS PS, PS, PL1, PL2; Siroperio 1\u002F2\u002F3\u002F7; Woodpecker P3; Acteon 10Z). Treatment is carried out under ≥3× magnification with emphasis on tissue preservation. The operator aims to achieve a stable blood clot emerging from the peri-implant pocket after instrumentation. No curettes or sharp instruments are used.",[15],[31],"MINST",null,[34],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"MDDr. Filip Hromčík, Ph.D., MDDr., Ph.D.","CONTACT","+420 607987134","filiphromcik@mail.muni.cz",[40],{"facility":41,"status":42,"city":43,"state":32,"zip":44,"country":45,"countryCode":32,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Syndenta s.r.o., Hlinky 92, 603 00 Brno, Czech Republic","RECRUITING","Brno","60300","Czechia",{"type":47,"coordinates":48},"Point",[49,50],16.60796,49.19522,{"lat":50,"lon":49},[53,54,58,61],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},{"name":55,"role":36,"phone":56,"phoneExt":32,"email":57},"Petr Kořínek, MUDr.","+420 773 646 646","petr@syndenta.cz",{"name":59,"role":60,"phone":32,"phoneExt":32,"email":32},"Filip Hromčík, MDDr., Ph.D.","PRINCIPAL_INVESTIGATOR",{"name":62,"role":63,"phone":32,"phoneExt":32,"email":32},"Veronika Chuchmová, Mgr.","SUB_INVESTIGATOR",{"type":60,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Filip Hromcik","Principal Investigator",[68],{"name":69,"class":6},"King's College London","100628847","minimally-invasive-non-surgical-therapy-of-peri-implantitis-100628847",false,"NCT07466966","Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis","Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)","MINST vs NSPT","Inclusion Criteria:\n\n* Age ≥18\n* Peri-implantitis diagnosis (PPD \\>6 mm, BOP+, bone loss ≥3 mm)\n* Accessible implant surface without removing suprastructure\n* FMPS \\\u003C30%, FMBS \\\u003C30-35%\n\nExclusion Criteria:\n\n* Antibiotics in last 3 months\n* Pregnancy\u002Flactation\n* Uncontrolled diabetes (HbA1c ≥7)\n* Long-term SPIC (\\>2 years)\n* Previous implant therapy \\\u003C12 months\n* Smoking\u002Fvaping in last 12 months\n* Hopeless implant\n* Need for adjunctive antibiotics","ALL","18 Years",{"count":81,"type":82},106,"ESTIMATED","INTERVENTIONAL",[85],"NA","This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.",[88,89,90],"Peri-implantitis","Periodontitis","Non-surgical Periodontal Therapy",[92,31,93,94,95,96],"peri-implantitis","non-surgical therapy","ultrasonic debridement","implant dentistry","randomised controlled trial","2026-03-11",{"date":99,"type":100},"2026-03-13","ACTUAL",{"date":102,"type":100},"2026-01-01",{"date":104,"type":82},"2028-04",{"name":5,"class":6},1]