[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602209":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":34,"locations":40,"responsibleParty":115,"collaborators":10,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":121,"sex":126,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":132,"studyType":133,"phases":10,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"Medical University of Silesia","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"RLH",null,"Radical laparoscopic hysterectomy",[13,14,15],"Other: CT scan","Procedure: Ultrasound scan (Transvaginal or Transabdominal)","Procedure: Gynecological examination",{"label":17,"type":10,"description":18,"interventionNames":19},"RAL","Radical open hysterectomy",[13,14,15],[21,25,30],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"CT scan","CT chest, abdominal, pelvis during follow-up",[17,9],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"PROCEDURE","Ultrasound scan (Transvaginal or Transabdominal)","Transvaginal and transabdominal ultrasound scan during follow-up",[17,9],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Gynecological examination","Gynecological standard examination during follow-up",[17,9],[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Krzysztof Nowosielski, professor","CONTACT","+48 502027943","knowosielski@sum.edu.pl",[41,60,73,87,101],{"facility":42,"status":43,"city":44,"state":10,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Uniwersyteckie Centrum Onkologii, Uniwersytecki Szpital Kliniczny w Białymstoku","NOT_YET_RECRUITING","Bialystok","15-276","Poland","PL",{"type":49,"coordinates":50},"Point",[51,52],23.16433,53.13333,{"lat":52,"lon":51},[55],{"name":56,"role":37,"phone":57,"phoneExt":58,"email":59},"Paweł Knapp, Professor","85 831 80 23","+48","pawel.knapp@umb.edu.pl",{"facility":61,"status":62,"city":63,"state":10,"zip":64,"country":46,"countryCode":47,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Department of Gynaecology, Obstetrics and Gynaecological Oncology, University Clinical Centre, Medical University of Silesia","RECRUITING","Katowice","40-757",{"type":49,"coordinates":66},[67,68],19.02173,50.2597,{"lat":68,"lon":67},[71],{"name":72,"role":37,"phone":38,"phoneExt":10,"email":39},"Krzysztof Nowosielski, Professor",{"facility":74,"status":43,"city":75,"state":10,"zip":76,"country":46,"countryCode":47,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Klinika Ginekologii, Świętokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakład Opieki Zdrowotnej","Kielce","25-734",{"type":49,"coordinates":78},[79,80],20.62752,50.87033,{"lat":80,"lon":79},[83],{"name":84,"role":37,"phone":85,"phoneExt":58,"email":86},"Marcin Misiek, PhD","41 367 42 08","mmisiek@me.com",{"facility":88,"status":62,"city":89,"state":10,"zip":90,"country":46,"countryCode":47,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Oddział Ginekologii Onkologicznej z Pododdziałem Urologii, Opolskie Centrum Onkologii","Opole","45-061",{"type":49,"coordinates":92},[93,94],17.92604,50.67119,{"lat":94,"lon":93},[97],{"name":98,"role":37,"phone":99,"phoneExt":58,"email":100},"Ewa Milnerowicz-Nabzdyk, Professor","77 441 6079","ewa.milnerowicz@wp.pl",{"facility":102,"status":62,"city":103,"state":10,"zip":104,"country":46,"countryCode":47,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Department of Gynaecological Oncology,","Wroclaw","53-413",{"type":49,"coordinates":106},[107,108],17.03006,51.10286,{"lat":108,"lon":107},[111],{"name":112,"role":37,"phone":113,"phoneExt":10,"email":114},"Marcin Jędryka, PhD","71 368 93 91","marcin.jedryka@umw.edu.pl",{"type":116,"investigatorFullName":117,"investigatorTitle":118,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Krzysztof Nowosielski","Prof.","100602209","minimally-invasive-surgery-versus-open-radical-hysterectomy-in-presumably-early-stage-cervical-cancer-a-retrospective-multicenter-non-inferiority-study-comparing-overall-and-progression-free-survival-100602209",false,"NCT07120529","Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective Multicenter Non-inferiority Study Comparing Overall and Progression-free Survival.","MOOSE","Inclusion Criteria:\n\nWomen undergoing radical hysterectomy type B or C according to the Querleu-Morrow classification for early-stage cervical cancer (FIGO stages IB1-IIA1, excluding FIGO IB3 between November 2018 and August 2025 Not using manipulator during surgery Vaginal cuff protective maneuver during surgery Conization before surgery (optional) SNB as a first stage of treatment (optional)\n\nExclusion Criteria:\n\nWomen undergoing surgery for advanced stage cervical cancer (FIGO \\>IIA1) or FIGO IB3 Metastasis detected in sentinel node biopsy (confirmed in ultrastaging) ECOG\\>2 Not willing to participate in the study Not willing to undergo CT-scans or gynecological examinations","FEMALE","18 Years","85 Years",{"count":130,"type":131},300,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this retrospective observational study with prospective follow-up is to compare the safety and treatment outcomes of radical laparoscopic hysterectomy (removal of the uterus with cervix) versus abdominal (open) hysterectomy performed after the publication of the LACC trial in women with early-stage cervical cancer.\n\nEligible participants will include adult, legally competent women diagnosed with early-stage cervical cancer (FIGO stages IB1-IIA1, excluding FIGO IB3) with negative sentinel lymph node biopsy (SNB) confirmed by ultrastaging.\n\nThe main questions it aims to answer are:\n\nIs there a difference in overall survival (OS) and progression-free survival (PFS) between laparoscopic and abdominal radical hysterectomy? Are postoperative complication rates and recurrence patterns comparable between the two surgical approaches?\n\nResearchers will compare outcomes in patients undergoing radical laparoscopic hysterectomy versus abdominal hysterectomy to assess differences in survival, complications, and recurrence.\n\nParticipants will:\n\nHave undergone radical hysterectomy (type B or C per Querleu-Morrow classification), preceded optionally by conization, with the use of uterine manipulators and absence of vaginal cuff protection explicitly excluded; Have had SNB as part of surgical staging; Be followed every 6 months for 5 years; Undergo clinical gynecologic examination and transvaginal and\u002For transabdominal ultrasound during follow-up; Undergo additional imaging (CT and\u002For pelvic MRI) in case of symptoms suggestive of recurrence.\n\nAll participants will follow standard post-treatment surveillance. No additional interventions beyond routine follow-up will be performed. Data on OS, PFS, complications (within 30 and 60 days postoperatively, classified by Clavien-Dindo), duration of surgery, recurrence site, and demographic characteristics will be collected.",[136,137],"Cervical Cancer","Hysterectomy",[139,140,141,142,143],"cervical cancer","radical laparoscopic hysterectomy","radical abdominal hysterectomy","protective maneuver","LACC study","2025-08-12",{"date":146,"type":147},"2025-08-13","ACTUAL",{"date":149,"type":131},"2025-09-15",{"date":151,"type":131},"2030-12-01",{"name":5,"class":6},5]