[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100434782":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":21,"centralContacts":25,"locations":32,"responsibleParty":51,"collaborators":30,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":30,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":30,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":35,"whyStopped":30,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Levobupivacaine","Superior trunk nerve block will be done under ultrasound guidance to patients scheduled for shoulder surgeries. Local anesthetic agent (0.5% levobupivacaine) 8ml will be injected at the superior trunk of the brachial plexus in order to produce surgical anesthesia or analgesia for shoulder surgeries.",[12],"Drug: 0.5% levobupivacaine",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","0.5% levobupivacaine","This study adopts a \"Modified Narayana rule (MNR)\", a sequential up-and-down pharmacodynamics method (UDM) to estimate the minimum effective local anesthetic volume of 90% (MELVA90) of cases of the aforementioned local anesthetic (LA), in order to produce the surgical anesthesia of the patients scheduled for shoulder surgeries. Based on the principal investigator's clinical experience, the initial volume of 8ml will be used. Depending on the success or failure of the superior trunk block, which is defined as the readiness for surgery at 30 minutes after the block, the volume for the next patient will be adjusted up or down by 2ml. The upper dose limit of the study to minimize the potential for local anesthetic systemic toxicity will be 16ml and the lower dose limit will be 4ml, which will be of no clinical importance.",[9],[20],"Peripheral nerve block",[22],{"name":23,"affiliation":5,"role":24},"Manoj K Karmakar, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Ayla Wong, RN, BN","CONTACT","+85235056157",null,"aylawong@cuhk.edu.hk",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":30,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Department of Anaesthesia & Intensive Care, Prince of Wales Hospital","RECRUITING","Shatin","New Territories","Hong Kong","HK",{"type":41,"coordinates":42},"Point",[43,44],114.18333,22.38333,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":30,"email":50},"Winnie Samy, RN, BN, MSc","+85235052734","wsamy@cuhk.edu.hk",{"type":24,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Prof Manoj K Karmakar","Professor","100434782","minimum-effective-local-anesthetic-volume-for-ultrasound-guided-superior-trunk-block-100434782",false,"NCT04941664","Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block","Minimum Effective Local Anesthetic Volume of 0.5% Levobupivacaine Required for Ultrasound Guided Superior Trunk Block for Shoulder Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III scheduled to undergo elective upper shoulder arthroscopic rotator cuff repair procedure\n\nExclusion Criteria:\n\n* Patient refusal\n* pregnancy\n* skin infection at the site of block placement\n* history of allergy to local anaesthetic drugs\n* bleeding tendency or with evidence of coagulopathy\n* pre-existing neurological deficit or neuromuscular disease.","ALL","18 Years","75 Years",{"count":65,"type":66},25,"ESTIMATED","INTERVENTIONAL",[69],"NA","The objective of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug \"levobupivacaine\" required to produce an effective ultrasound guided (USG) superior trunk block (STB) in at least 90% of patients for shoulder arthroscopic surgeries.",[72],"Musculoskeletal Diseases or Conditions",[74],"Superior Trunk nerve block","2025-04-09",{"date":77,"type":78},"2025-04-13","ACTUAL",{"date":80,"type":78},"2023-01-19",{"date":82,"type":66},"2026-08-31",{"name":5,"class":6},1]