[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596155":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":76,"collaborators":79,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":25,"eligibilityCriteria":90,"healthyVolunteers":86,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":25,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Northwestern University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MINT group","EXPERIMENTAL","MINT training of two leg muscles",[13],"Other: myoelectric interface for neurorehabilitation (MINT) conditioning",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham group","SHAM_COMPARATOR","one muscle feedback",[19],"Other: One muscle myoelectric feedback",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"myoelectric interface for neurorehabilitation (MINT) conditioning","Myoelectric interface for neurorehabilitation (MINT) conditioning involves training to reduce abnormal co-activation of limb muscles to improve movement.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"One muscle myoelectric feedback","Training to control muscle activity in one muscle only.",[15],[31],{"name":32,"affiliation":5,"role":33},"Marc Slutzky, MD, PhD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","312-503-4653","mslutzky@northwestern.edu",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Cynthia Gorski","312-503-6097","cynthia.gorski@northwestern.edu",[44,60],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Chicago","Illinois","60611","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-87.65005,41.85003,{"lat":55,"lon":54},[58],{"name":59,"role":36,"phone":37,"phoneExt":25,"email":38},"Study Principal Investigator",{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":49,"countryCode":50,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"University of Texas Southwestern Medical Center","NOT_YET_RECRUITING","Dallas","Texas","75390",{"type":52,"coordinates":67},[68,69],-96.80667,32.78306,{"lat":69,"lon":68},[72],{"name":73,"role":36,"phone":74,"phoneExt":25,"email":75},"Yasin Dhaher, PhD","847-331-0793","yasin.dhaher@utsouthwestern.edu",{"type":33,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Marc Slutzky","Professor of Neurology",[80,83],{"name":81,"class":82},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":61,"class":6},"100596155","mint-conditioning-to-improve-gait-100596155",false,"NCT07041775","MINT Conditioning to Improve Gait","MINT Conditioning to Improve Post-stroke Gait","Inclusion Criteria:\n\n* Age at enrollment is 18 to 85\n* Leg impairment from unilateral stroke at least 6 months prior to screening\n* Severe to moderate gait impairment (ambulatory with a maximum walking speed of 0.8 m\u002Fs, i.e., half of normal speed)\n* Able to stand without assistance\n* Clinically observable gait asymmetry\n* Abnormal co-activation between adductor magnus and rectus femoris (R greater than or equal to 0.5)\n\nExclusion Criteria:\n\n* Cognitive impairment with at least moderately impaired attention on digit-span test, or unable to follow instructions of the MINT task\n* Visual impairment (such as hemianopia) preventing sufficient perception of the screen to play the games\n* Anesthesia or severe neglect in the affected leg, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) that impairs ability to play the games\n* Participation in another study on the affected leg, or any pharmacological study, within 6 weeks of enrollment\n* Inability to understand or follow commands in English due to aphasia or other reason that makes it impossible to perform the training\n* Diffuse or multifocal infarcts\n* Substantial leg or other pain preventing participation for 60 minutes a day\n* Spasticity treatment (pharmacological or Botox) on the affected leg within past 3 months\n* Severe osteoporosis causing hip or other fractures\n* History of multiple falls within the last year, use of walker for balance, or falling during stance while in the lab in the first session.\n* Contracture limiting the range of motion of the leg\n* Current pregnancy\n* From the TMS portion of the study only: History of epilepsy in adulthood requiring antiseizure medications; recent\u002Fcurrent alcoholism or benzodiazepine\u002Fbarbiturate abuse or recent history of alcohol\u002Fbenzodiazepine\u002Fbarbiturate withdrawal, recent history of cocaine or amphetamine use, skull fractures or skull deficits, concussion within the last 6 months, unexplained recurring headaches, vagus nerve stimulator, cochlear implant, deep brain stimulator, intracranial\u002Fcarotid stents, cardiac pacemaker\u002FAICD.","ALL","18 Years","85 Years",{"count":95,"type":96},72,"ESTIMATED","INTERVENTIONAL",[99],"NA","This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function.",[102,103],"Stroke","Stroke Gait Rehabilitation",[105,106,107,108,109,110],"Stroke rehabilitation","Leg impairment","Walking","Rehabilitation gaming","Muscle biofeedback","Myoelectric interface","2026-06-04",{"date":113,"type":114},"2026-06-08","ACTUAL",{"date":111,"type":114},{"date":117,"type":96},"2030-03",{"name":5,"class":6},2]