[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100309359":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":31,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Adult pilots",null,"Healthy adults between the ages of 18-65 years",{"label":13,"type":10,"description":14,"interventionNames":10},"AR infants","Infants with 12 months of age (+\u002F- 2 weeks) with one of the following: observed developmental delay, sibling of a child with autism, premature birth, small for gestational age.",{"label":16,"type":10,"description":17,"interventionNames":10},"TD infants","Healthy infants with 9 months of age (+\u002F- 2 weeks)",[19],{"name":20,"affiliation":21,"role":22},"Amir H Gandjbakhche, Ph.D.","Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Maria J Ayoub, Ph.D.","CONTACT","(301) 435-9235","maria.ayoub@nih.gov",{"name":20,"role":26,"phone":27,"phoneExt":10,"email":30},"gandjbaa@mail.nih.gov",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-77.10026,38.98067,{"lat":44,"lon":43},[47],{"name":48,"role":26,"phone":49,"phoneExt":50,"email":51},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY8664111010","prpl@cc.nih.gov",{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100309359","mirror-neuron-network-dysfunction-as-an-early-biomarker-of-neurodevelopmental-disorder-100309359",false,"NCT03307317","Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder","* INCLUSION CRITIERIA:\n\nHealthy adults\n\n* Age of 18-65 at study entry\n* Healthy and good condition as determined by medical history and physical examination\n\nHealthy Infants\n\n* 9 months +\u002F- 2 weeks of age at time of consent\n* Healthy and good condition as determined by medical history and physical examination\n* Age appropriate development as determined by parent report and exam\n* Full term at birth\n* Normal weight for gestational age\n\nAt Risk Infants\n\n* 12 months +\u002F- 2 weeks at the time of consent\n* Must have at least one of the following: observed developmental delay; sibling of a child with autism; premature birth; small for gestational age\n\nEXCLUSION CRITERIA:\n\nHealthy Adults\n\n* Uncorrected auditory impairment\n* Uncorrected visual impairment\n* Head injury with loss of consciousness\n* Inability to provide consent\n* Subject has a condition, that in the opinion of the investigator, creates an unacceptable risk for participation\n\nHealthy and At-Risk Infants\n\n* A language other than English as the primary language spoken at home\n* Having a medical impairment that interferes with study participation such as having a g-tube, shunt or seizure disorder and inability to hold one s head upright\n* Having a known visual impairment\n* Having a known auditory impairment",true,"ALL","9 Months","65 Years",{"count":65,"type":66},200,"ESTIMATED","OBSERVATIONAL","Background:\n\nPeople show changes in brain activity when they watch other people do actions. This may be part of early social and communication skills. Researchers want to understand the stages of normal development of motor observation and imitation in people and how it relates to social development in infants and toddlers.\n\nObjective:\n\nTo study the nature of brain activity that underlies typical brain functioning in infants, toddlers, and adults.\n\nEligibility:\n\nInfants ages 8 12 months\n\nHealthy adults ages 18 65\n\nDesign:\n\nAdult participants will have one visit. They will:\n\nAnswer questions about their family, like its size and ethnicity.\n\nAnswer questions about their own behavior and do a simple motor task.\n\nHave EEG\u002FfNIRS. A damp elastic cap with small sensors will be placed on the head. Participants will observe stimuli, either on a video screen or of a live person. The sensors will be connected to a computer. That will record the participant s brain activity while watching pictures on a screen.\n\nInfant participants will have 2 visits.\n\nTheir parents will answer questions about their family.\n\nThe parents will fill out forms about their child s development. These will be mailed to them before each visit.\n\nParents will stay with their infant while study staff does an assessment of the child s communication, motor, and thinking skills.\n\nInfants will have EEG\u002FfNIRS.\n\nInfants who are at risk for developmental delays will come back for another visit when they are about 2 years old. This will repeat the infant visits but it will not include EEG\u002FfNIRS.\n\nSome questionnaires and assessments will be videotaped.",[70],"Developmental Delay",[72,73,74,75,76],"Near Infrared Spectroscopy","EEG","Functional Brain Activity","Neurodevelopment","Natural History","2026-05-28",{"date":79,"type":80},"2026-05-29","ACTUAL",{"date":82,"type":80},"2018-08-30",{"date":84,"type":66},"2031-02-01",{"name":21,"class":6},1]