[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632973":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":10,"locations":38,"responsibleParty":61,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":80,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":89,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,16],{"label":9,"type":10,"description":10,"interventionNames":11},"Control Individuals",null,[12,13,14,15],"Diagnostic Test: Peripheral Vascular Imaging","Diagnostic Test: Coro-CT","Diagnostic Test: Neurocognitive Assesment","Procedure: Blood Sampling",{"label":17,"type":10,"description":10,"interventionNames":18},"Patients with Coronary Artery Disease",[12,13,14,15],[20,25,29,33],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Peripheral Vascular Imaging","Peripheral Vascular Imaging of Carotid and Femoral Arteries by Eco-Doppler Ultrasound",[9,17],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Coro-CT","Coronary Computed Axial Tomography (Coro-TC) with contrast administration",[9,17],{"type":21,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"Neurocognitive Assesment","Study of neurocognitive function and decline by pre-established tests",[9,17],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":10},"PROCEDURE","Blood Sampling","Blood sampling for further molecular and cellular analysis",[9,17],[39],{"facility":5,"status":10,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Rome","Lazio","00168","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],12.51133,41.89193,{"lat":49,"lon":48},[52,57],{"name":53,"role":54,"phone":55,"phoneExt":10,"email":56},"Giovanna Liuzzo, MD, PhD","CONTACT","+39 06 3015 6549","giovanna.liuzzo@policlinicogemelli.it",{"name":58,"role":54,"phone":59,"phoneExt":10,"email":60},"Francisco R Jimenez Trinidad, BSc, MSc, PhD","+39 06 3015 6621","franciscorafael.jimenez-trinidad@policlinicogemelli.it",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Liuzzo Giovanna","Medical Doctor, Cardiologist - Head of the Acute Coronary Syndromes Unit - Head of the Molecular and Cellular Cardiology Laboratory","100632973","mistic-study-atherosclerosis-neurocognition--cardiovascular-signaling-100632973",false,"NCT07520643","MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling","Multilevel and Interdisciplinary Assessment of Subclinical to Clinical Atherosclerosis Interactions With Neurocognitive Function and Cardiovascular System Through Endothelial and Inflammatory Cell Signalling: The MISTIC Study","MISTIC","Control Group\n\nInclusion Criteria:\n\n* Age \\>= 18 years\n* Capacity to provide informed consent\n* Documented coronary artery stenosis ≥ 50 % through peripheral vascular ultrasound imaging.Documented coronary artery stenosis ≥ 50 % through peripheral vascular ultrasound imaging.\n\nExclusion Criteria:\n\n* Prior ischemic cardiac events (e.g., myocardial infarction, unstable angina).\n* Major electrophysiological disorders.\n* History of stroke or transient ischemic attack.\n* Ongoing renal replacement therapy (dialysis).\n* Use of systemic immunosuppressive or anti-inflammatory medications (beyond low-dose aspirin).\n* Any chronic inflammatory or autoimmune disease.\n* Active infectious disease at the time of enrolment.\n* Active malignancy or cancer treatment within the past 5 years.\n\nCoronary Artery Disease Group\n\nInclusion Criteria:\n\n* Age \\>= 18 years\n* Capacity to provide informed consent\n\nExclusion Criteria:\n\n* Prior ischemic cardiac events (e.g., myocardial infarction, unstable angina).\n* Major electrophysiological disorders.\n* History of stroke or transient ischemic attack.\n* Ongoing renal replacement therapy (dialysis).\n* Use of systemic immunosuppressive or anti-inflammatory medications (beyond low-dose aspirin).\n* Any chronic inflammatory or autoimmune disease.\n* Active infectious disease at the time of enrolment.\n* Active malignancy or cancer treatment within the past 5 years.",true,"ALL","18 Years","80 Years",{"count":78,"type":79},1000,"ESTIMATED","6 Months","OBSERVATIONAL","The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.\n\nAtherosclerosis is a progressive condition characterized by the accumulation of material within arterial walls, leading to vascular narrowing and impaired blood flow. While its most recognized consequences are acute events such as myocardial infarction or stroke, earlier stages of the disease, often asymptomatic, may already be associated with functional changes affecting multiple organ systems.\n\nThis study focuses on evaluating the association between vascular health and cognitive performance at a single time point. Atherosclerotic burden will be assessed using non-invasive imaging techniques, including carotid intima-media thickness and coronary calcium scoring. Cognitive performance will be measured using standardized neuropsychological tests.\n\nApproximately 1000 participants will be enrolled and divided into two groups: a control group without clinically established cardiovascular disease, and a group of patients with coronary artery disease (CAD). All participants will undergo clinical evaluation, vascular imaging, cognitive testing, and analysis of biological samples.\n\nThe primary objective is to determine whether increasing atherosclerotic burden is associated with measurable differences in cognitive and cardiovascular function. Secondary aims include identifying patterns that may help improve early detection and risk stratification of vascular disease.\n\nThe results of this study are expected to contribute to a better understanding of atherosclerosis as a systemic condition and to support the development of preventive strategies targeting early stages of vascular disease.",[84,85],"Subclinical Atherosclerotic Cardiovascular Disease","Neurocognitive Decline",[87,85,88],"Atherosclerosis","Inflammation","NOT_YET_RECRUITING","2026-04-02",{"date":92,"type":93},"2026-04-09","ACTUAL",{"date":95,"type":79},"2026-05-01",{"date":97,"type":79},"2030-04-30",{"name":5,"class":6},1]