[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605721":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":49,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":27,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":52,"whyStopped":27,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Kansas State University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group (TRAIN)","EXPERIMENTAL","This group will receive the experimental intervention",[13,14,15],"Device: Wrist immobilization","Behavioral: Resistance training","Behavioral: Resistance training rehabilitation",{"label":17,"type":18,"description":19,"interventionNames":20},"Control Group (CON)","ACTIVE_COMPARATOR","This group will not receive the experimental intervention",[13,15],[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Wrist immobilization","The wrist immobilization will use a medical device (wrist cast) to immobilize the left, non-dominant wrist for 7 days.",[17,9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Resistance training","The cross-education intervention will consist of resistance training on the dominant hand.",[9],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"Resistance training rehabilitation","The resistance training rehabilitation will occur for the non-dominant hand following the immobilization phase for all participants.",[17,9],[38],{"name":39,"affiliation":5,"role":40},"Joshua Carr, Ph.D.","PRINCIPAL_INVESTIGATOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":27,"email":45},"CONTACT","785-532-0700","joshuacarr@ksu.edu",{"name":47,"role":43,"phone":27,"phoneExt":27,"email":48},"Julio Hernandez-Pavon, Ph.D.","juliohpavon@ksu.edu",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Neuromuscular Physiology Laboratory","RECRUITING","Manhattan","Kansas","66506","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-96.57167,39.18361,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":44,"phoneExt":27,"email":45},"Joshua Carr, PhD",{"type":40,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Joshua Carr","Assistant Professor",[71],{"name":72,"class":73},"National Institute of General Medical Sciences (NIGMS)","NIH","100605721","mitigating-neural-hypoexcitability-and-weakness-during-disuse-in-women-100605721",false,"NCT07166198","Mitigating Neural Hypoexcitability and Weakness During Disuse in Women","MiND","Inclusion Criteria:\n\n* Women between 40-65 years of age\n* Baseline handgrip strength \\>16Kg\n\nExclusion Criteria:\n\n* Personal or family history of blood clots\n* Current use of anticoagulant medications\n* Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)\n* Arthritis\n* Osteoporosis or osteopenia\n* History of myocardial infarction within the past year\n* Chronic pain ≥3\u002F10 for ≥3 months\n* Uncontrolled hypertension (≥140\u002F90 mmHg)\n* Upper extremity surgery within the past year\n* Use of assistive hand or arm device within the past year\n* Fall involving the upper extremities within the past year\n* Upper extremity injuries preventing safe participation\n* Current use of muscle relaxants, benzodiazepines, or similar drugs\n* Smoking within the past 6 months\n* History of drug or alcohol abuse within the past year\n* Severe anxiety or claustrophobia\n* Pregnancy (current or planned)\n* Allergies to medical adhesives\n* High risk of sarcopenia (per SARC-F)\n* Contraindications to TMS or MRI\n* Upper-body resistance training within the past 6 months\n* Inability\u002Funwillingness to refrain from resistance training during study",true,"FEMALE","40 Years","65 Years",{"count":86,"type":87},20,"ESTIMATED","INTERVENTIONAL",[90],"NA","Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife.\n\nThe main questions it aims to answer are:\n\nWhat changes happen in the nervous system that lead to weakness when a wrist is immobilized?\n\nCan training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm?\n\nResearchers will compare women who have their wrist immobilized with or without opposite-arm resistance training.\n\nParticipants will:\n\nWear a wrist cast on one arm for 7 days\n\nComplete strength training with the opposite arm or no training, depending on their group\n\nAttend study visits for strength and nervous system testing\n\nHave non-invasive tests (like magnetic brain stimulation, muscle recordings, and muscle imaging) to measure how the nervous system and muscle responds",[93],"Muscle Weakness",[95,96,97,24,98],"Resistance Training","Neuroplasticity","Muscle Disuse","Women's Health","2026-06-09",{"date":101,"type":102},"2026-06-10","ACTUAL",{"date":104,"type":102},"2026-05-01",{"date":106,"type":87},"2027-01-31",{"name":5,"class":6},1]