[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633690":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":20,"collaborators":10,"id":24,"slug":25,"hasResults":26,"nctId":27,"briefTitle":28,"officialTitle":29,"acronym":10,"eligibilityCriteria":30,"healthyVolunteers":26,"sex":31,"minAge":32,"maxAge":33,"enrollmentInfo":34,"targetDuration":10,"studyType":37,"phases":10,"briefSummary":38,"conditions":39,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":10},{"fullName":5,"class":6},"TC Erciyes University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Standardized Root Canal Treatment",null,"Participants will undergo standardized nonsurgical root canal treatment using a uniform clinical protocol. Radiographic healing outcomes will be evaluated at 12 months, and results will be analyzed in relation to MMP-2 and MMP-3 gene polymorphisms.",[13],"Procedure: Nonsurgical Root Canal Treatment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Nonsurgical Root Canal Treatment","All participants will undergo standardized nonsurgical root canal treatment performed under a uniform clinical protocol. After local anesthesia and rubber dam isolation, working length will be determined electronically and radiographically. Root canal preparation will be completed with rotary instrumentation up to size 30\u002F.06, accompanied by sodium hypochlorite irrigation, EDTA, and ultrasonic activation. Canals will then be obturated in the same visit using gutta-percha and epoxy resin-based sealer with the warm vertical condensation technique. Periapical healing outcomes at 12 months will be evaluated in relation to MMP-2 and MMP-3 genetic polymorphisms.",[9],{"type":21,"investigatorFullName":22,"investigatorTitle":23,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ayşe Tuğba Eminsoy Avcı","Lecturer","100633690","mmp-23-and-periapical-healing-outcomes-100633690",false,"NCT07529964","MMP-2\u002F3 and Periapical Healing Outcomes","Association of MMP-2 and MMP-3 Polymorphisms With 12-Month Radiographic Healing After Nonsurgical Root Canal Treatment in Chronic Apical Periodontitis: A Prospective Clinical Study","Inclusion Criteria:\n\n* Single-rooted teeth\n* PAI score ≥ 3\n* Fully developed root apices\n* Periodontal probing depth less than 5 mm\n* Indication for primary nonsurgical root canal treatment\n\nExclusion Criteria:\n\n* Previous endodontic treatment in the selected tooth\n* Diagnosis of symptomatic apical abscess\n* Presence of root fracture or internal\u002Fexternal resorption\n* Use of systemic antibiotics within the previous 4 weeks\n* Analgesic intake within 48 hours before treatment\n* Ongoing immunosuppressive therapy\n* Pregnancy or breastfeeding","ALL","18 Years","65 Years",{"count":35,"type":36},50,"ESTIMATED","OBSERVATIONAL","This prospective randomized clinical study will investigate the association between MMP-2 and MMP-3 gene polymorphisms and radiographic healing outcomes following nonsurgical root canal treatment in patients with chronic apical periodontitis. A total of 50 patients will undergo standardized endodontic treatment and will be followed for 12 months. Genotyping will be performed using baseline DNA samples, and periapical healing will be assessed using the Periapical Index (PAI). The relationship between genetic variations and treatment outcomes will be analyzed to determine whether host-related genetic factors influence healing patterns after root canal therapy.",[40,41],"Chronic Apical Periodontitis","Periapical Healing","NOT_YET_RECRUITING","2026-04-08",{"date":45,"type":46},"2026-04-14","ACTUAL",{"date":48,"type":36},"2026-05-15",{"date":50,"type":36},"2027-06-25",{"name":5,"class":6}]