[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645085":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":41,"centralContacts":45,"locations":53,"responsibleParty":82,"collaborators":10,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":10,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":112,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8,14,19,22],{"label":9,"type":6,"description":10,"interventionNames":11},"ITP-ANA-",null,[12,13],"Procedure: Blood sampling baseline and M3","Other: Monitoring for SLE",{"label":15,"type":6,"description":10,"interventionNames":16},"ITP-ANA+",[17,18],"Procedure: Procedure\u002FSurgery: Blood sampling baseline and M3 then each 6 months until 48 months","Other: moniktoring for SLE : baseline and M3 then each 6 months until 48 months",{"label":20,"type":6,"description":10,"interventionNames":21},"SLE",[12,13],{"label":23,"type":6,"description":10,"interventionNames":24},"Controls",[12,13],[26,31,35,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"PROCEDURE","Blood sampling baseline and M3","Blood sampling is a routine biological procedure performed under the same conditions as during a follow-up consultation.",[23,9,20],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Monitoring for SLE","Monitoring for Systemic Lupus Erythematosus according to SLICC 2012 classification criteria",[23,9,20],{"type":27,"name":36,"description":29,"armGroupLabels":37,"otherNames":10},"Procedure\u002FSurgery: Blood sampling baseline and M3 then each 6 months until 48 months",[15],{"type":6,"name":39,"description":33,"armGroupLabels":40,"otherNames":10},"moniktoring for SLE : baseline and M3 then each 6 months until 48 months",[15],[42],{"name":43,"affiliation":5,"role":44},"Jérôme GRANEL, MD","PRINCIPAL_INVESTIGATOR",[46,50],{"name":43,"role":47,"phone":48,"phoneExt":10,"email":49},"CONTACT","+33 5 57 82 02 55","jerome.granel@chu-bordeaux.fr",{"name":51,"role":47,"phone":10,"phoneExt":10,"email":52},"Nathalie ALADJIDI, MD","nathalie.aladjidi@chu-bordeaux.fr",[54,68],{"facility":55,"status":10,"city":56,"state":10,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Chu de Bordeaux- Groupe Hospitalier Pellegrin - Hôpital des Enfants","Bordeaux","33076","France","FR",{"type":61,"coordinates":62},"Point",[63,64],-0.58046,44.84124,{"lat":64,"lon":63},[67],{"name":43,"role":47,"phone":48,"phoneExt":10,"email":49},{"facility":69,"status":10,"city":70,"state":10,"zip":71,"country":58,"countryCode":59,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"CHU Toulouse - Hôpital des Enfants","Toulouse","31026",{"type":61,"coordinates":73},[74,75],1.44367,43.60426,{"lat":75,"lon":74},[78],{"name":79,"role":47,"phone":80,"phoneExt":10,"email":81},"Marlène PASQUET, PROF","+33 5 34 55 86 43","pasquet.m@chu-toulouse.fr",{"type":83,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100645085","model-early-immunologic-stages-of-pediatric-hematological-pre-lupus-100645085",false,"NCT07680010","Model Early Immunologic Stages of Pediatric Hematological Pre-lupus","Model Early Immunologic Stages of Pediatric Hematological Pre-lupus in Order to Prevent SLE in Children.","PRELUDE","* Inclusion criteria:\n\n  * For patients :\n\n    * Child or adolescent with newly diagnosed ITP or SLE according to the specific definitions of ITP or SLE, prior to any treatment,\n    * Over 1 and under 18 years of age at diagnosis, weighing more than 7 kg.\n    * Written consent from parents or guardians,\n    * Patient affiliated to a social security scheme.\n  * For controls :\n\n    * Over 1 and under 18 years of age at diagnosis, weighing more than 7 kg.\n    * Follow-up in the day hospital at the Bordeaux University Hospital, for a condition that does not affect the immune system\n    * Matched on age,\n    * Written consent from parents or guardians,\n    * Patient affiliated to a social security scheme\n* Exclusion criteria:\n\n  * For patients :\n\n    * ITP secondary to a known cause: previous or concomitant immune deficiency, bone marrow or organ transplantation, other autoimmune disease, Evans syndrome (autoimmune hemolytic anemia or autoimmune neutropenia present at ITP diagnosis) or cancer with immunosuppressive therapy.\n    * Treatment with immunomodulation or immunosuppressants (including immunoglobulins, corticoids, hydroxychloroquine), started prior to inclusion (day of sampling).\n    * Pregnant women, women in labour and breastfeeding women\n  * For controls :\n\n    * Suffering from an immunological disease,\n    * Infection within fifteen days prior to inclusion,\n    * Immunomodulatory therapy.\n    * Pregnant women, women in labour and breastfeeding women",true,"ALL","1 Year","18 Years",{"count":97,"type":98},105,"ESTIMATED","INTERVENTIONAL",[101],"NA","Immunologic thrombocytopenic purpura (ITP) in children is a pre-lupus condition if associated with the presence of anti-nuclear antibodies (ANA), providing a unique model for understanding the natural history of autoimmunity, particularly that of systemic lupus erythematosus (SLE). We will describe the shared and\u002For unique immunological pathways involved at diagnosis in 70 children with ITP and in 20 children with SLE, and compare them between ITP-ANA- (more often transient), ITP-ANA+ (pre-lupus condition, more often persistent) and SLE",[104,105],"Immune Thrombocytopenic Purpura ( ITP )","Systemic Lupus Erythematosus (SLE)",[107,108,109,110,111],"Children","Immunologic Thrombocytopenic Purpura","Anti-Nuclear Antibody","Systemic Lupus Erythematosus","Biomarkers","NOT_YET_RECRUITING","2026-06-25",{"date":115,"type":116},"2026-07-01","ACTUAL",{"date":118,"type":98},"2026-07",{"date":120,"type":98},"2033-10",{"name":5,"class":6},2]