[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100424742":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":42,"centralContacts":46,"locations":55,"responsibleParty":74,"collaborators":76,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":32,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":32,"overallStatus":58,"whyStopped":32,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,15,19,23],{"label":9,"type":6,"description":10,"interventionNames":11},"HIV+ marijuana user","Participants with HIV who report marijuana use",[12,13,14],"Other: Multimodal, multi-parametric MRI","Other: Immune and cytokine profiling","Behavioral: Neuropsychological testing",{"label":16,"type":6,"description":17,"interventionNames":18},"HIV+ non-drug user","Participants with HIV who report no drug use",[12,13,14],{"label":20,"type":6,"description":21,"interventionNames":22},"HIV- marijuana user","Participants without HIV who report marijuana use",[12,13,14],{"label":24,"type":6,"description":25,"interventionNames":26},"HIV- non-drug user","Participants without HIV who report no drug use",[12,13,14],[28,33,37],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Multimodal, multi-parametric MRI","The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.",[9,16,20,24],null,{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Immune and cytokine profiling","Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.",[9,16,20,24],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"BEHAVIORAL","Neuropsychological testing","Participants will have neuropsychological testing three times over 2 years.",[9,16,20,24],[43],{"name":44,"affiliation":5,"role":45},"Christina S Meade, PhD","PRINCIPAL_INVESTIGATOR",[47,51],{"name":44,"role":48,"phone":49,"phoneExt":32,"email":50},"CONTACT","336-716-0695","Christina.Meade@wfusm.edu",{"name":52,"role":48,"phone":53,"phoneExt":32,"email":54},"Sheri L Towe, PhD","336-716-4331","Sheri.Towe@wfusm.edu",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Biotech Place","RECRUITING","Winston-Salem","North Carolina","27101","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-80.24422,36.09986,{"lat":68,"lon":67},[71,72,73],{"name":44,"role":48,"phone":49,"phoneExt":32,"email":50},{"name":52,"role":48,"phone":53,"phoneExt":32,"email":54},{"name":44,"role":45,"phone":32,"phoneExt":32,"email":32},{"type":75,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[77],{"name":78,"class":79},"National Institute on Drug Abuse (NIDA)","NIH","100424742","modeling-the-effects-of-chronic-marijuana-use-on-neuroinflammation-and-hiv-related-neuronal-injury-100424742",false,"NCT04810858","Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury","CHI","Inclusion Criteria:\n\n* verified HIV status\n* Current marijuana use (MJ+ groups only)\n* No current marijuana use (MJ- groups only)\n* current engagement in HIV care (HIV+ participants only)\n* receipt of cART as first-line of treatment (HIV+ participants only)\n* stable cART regimen (HIV+ participants only)\n* undetectable HIV RNA viral load for \\>1 year (HIV+ participants only)\n\nExclusion Criteria:\n\n* Lifetime abuse for any illicit drug other than marijuana\n* \\\u003C9th grade education; illiteracy or lack of fluency in English\n* history of moderate or severe head trauma\n* unstable or serious neurological disorders\n* severe mental illness\n* systemic autoimmune diseases\n* immunotherapy\n* MRI contraindications",true,"ALL","25 Years","59 Years",{"count":92,"type":93},220,"ESTIMATED","INTERVENTIONAL",[96],"NA","This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.",[99,100,101,102,103],"Cannabis","HIV","Inflammation","Cognition","Neuroimaging","2026-03-27",{"date":106,"type":107},"2026-03-31","ACTUAL",{"date":109,"type":107},"2021-08-18",{"date":111,"type":93},"2027-05-31",{"name":5,"class":6},1]