[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589817":3},{"organization":4,"armGroups":7,"interventions":38,"overallOfficials":37,"centralContacts":51,"locations":61,"responsibleParty":91,"collaborators":93,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":37,"eligibilityCriteria":102,"healthyVolunteers":99,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":37,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":64,"whyStopped":37,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Central Institute of Mental Health, Mannheim","OTHER",[8,14,19,23,28,33],{"label":9,"type":10,"description":11,"interventionNames":12},"right dlPFC","EXPERIMENTAL","tDCS anodal electrode over the right dlPFC (position F4, EEG cap 10\u002F20 system), cathodal electrode over the left dlPFC (position F3, EEG cap 10\u002F20 system).",[13],"Device: Transcranial direct current stimulation (tDCS)",{"label":15,"type":16,"description":17,"interventionNames":18},"left dlPFC","ACTIVE_COMPARATOR","tDCS anodal electrode over the left dlPFC (position F3, EEG cap 10\u002F20 system), cathodal electrode over the right dlPFC (position F4, EEG cap 10\u002F20 system).",[13],{"label":20,"type":16,"description":21,"interventionNames":22},"Occipital Cortex","tDCS anodal electrode over the occipital cortex (position O1, EEG cap 10\u002F20 system), cathodal electrode over position Cz (EEG cap 10\u002F20 system).",[13],{"label":24,"type":25,"description":26,"interventionNames":27},"Sham tDCS","SHAM_COMPARATOR","tDCS anodal electrode over the right dlPFC (position F4, EEG cap 10\u002F20 system), cathodal electrode over the left dlPFC (position F3, EEG cap 10\u002F20 system). The current is ramped up from 0.3mA to initially 2mA (0.1mA\u002Fs) and then immediately ramped down.",[13],{"label":29,"type":16,"description":30,"interventionNames":31},"Computerized Inhibition Training","Standardized computerized inhibition training using a go-\u002Fno-go-task with individually adapted, substance-related stimuli (wine, beer, spirits).",[32],"Behavioral: Inhibition Training",{"label":34,"type":35,"description":36,"interventionNames":37},"Treatment as Usual","NO_INTERVENTION","Patients only receive standard treatment in clinic (qualified detoxification program).",null,[39,46],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":44},"DEVICE","Transcranial direct current stimulation (tDCS)","tDCS sessions on five consecutive days for 20 minutes.",[20,24,15,9],[45],"Sooma Medical",{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":37},"BEHAVIORAL","Inhibition Training","Computerized Training of inhibitory control (Go-\u002FNo-Go task with pictures of preferred alcohol) on five consecutive days.",[29],[52,57],{"name":53,"role":54,"phone":55,"phoneExt":37,"email":56},"Sabine Vollstädt-Klein, PhD","CONTACT","+4962117033912","Sabine.Vollstaedt-Klein@zi-mannheim.de",{"name":58,"role":54,"phone":59,"phoneExt":37,"email":60},"Sarah Gerhardt, PhD","+4962117033927","Sarah.Gerhardt@zi-mannheim.de",[62,79],{"facility":63,"status":64,"city":65,"state":37,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Central Institute of Mental Health","RECRUITING","Mannheim","68159","Germany","DE",{"type":70,"coordinates":71},"Point",[72,73],8.46694,49.4891,{"lat":73,"lon":72},[76],{"name":77,"role":54,"phone":78,"phoneExt":37,"email":56},"Sabine Vollstaedt-Klein, PhD","+ 49 62117033912",{"facility":80,"status":81,"city":82,"state":37,"zip":83,"country":67,"countryCode":68,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Psychiatrisches Zentrum Nordbaden (Psychiatric Center Nordbaden)","NOT_YET_RECRUITING","Wiesloch","69168",{"type":70,"coordinates":85},[86,87],8.69846,49.29504,{"lat":87,"lon":86},[90],{"name":77,"role":54,"phone":78,"phoneExt":37,"email":56},{"type":92,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR",[94],{"name":95,"class":96},"Wellcome Leap Inc.","INDUSTRY","100589817","modification-of-inhibitory-control-and-craving-through-transcranial-direct-current-stimulation-tdcs-as-an-add-on-treatment-for-substance-use-disorder-100589817",false,"NCT06959342","Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder","Inclusion Criteria:\n\n* main diagnosis: alcohol use disorder according to DSM-5\n* patients of any gender aged 18 to 65\n* normal vision or correctable visual impairment.\n* sufficient ability to communicate verbally and in writing\n* ability to give fully informed consent after reviewing thorough written information\n\nExclusion Criteria:\n\n* withdrawal of consent\n* severe internal, neurological, or psychiatric comorbidities (e.g., lifetime schizophrenia, bipolar disorder, or other severe mental disorders according to ICD-10 and DSM-5, such as severe depression or PTSD within the last 12 months).\n* Exclusion criteria for an EEG\u002FtDCS examination (e.g. metal implants in the head, epilepsy, etc.)\n* severe withdrawal symptoms (CIWA-R \\> 7)\n* alcohol intoxication (breath alcohol concentration \\> 0 ‰)\n* Pharmacotherapy with psychoactive substances within the last 14 days (exceptions: clomethiazole or benzodiazepines used in withdrawal treatment, provided they were discontinued at least 3 days prior; antidepressants or anxiolytics taken at stable doses).\n* drug or alcohol use within the last 7 days\n* for women: pregnancy\n* suicidal tendencies or danger to others","ALL","18 Years","65 Years",{"count":107,"type":108},162,"ESTIMATED","INTERVENTIONAL",[111],"NA","The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on alcohol use disorder (AUD). Patients of any gender between the ages of 18 and 65 are examined who are in our inpatient and day clinic settings for a standard detoxification treatment program. As there are conflicting findings regarding the effective settings for tDCS as an adjunctive treatment in SUD (e.g., effects on inhibitory control seem to be sensitive to current direction), the aim is to examine and compare three different active tDCS conditions, a sham tDCS condition (placebo), inhibition training, and a control group of patients receiving only standard detoxification treatment. The aim is to identify the optimal electrode placement and current direction to positively influence both inhibitory control and craving, leading to improved treatment outcomes such as longer abstinence periods or reduced substance use after relapse.",[114,115],"Alcohol Use Disorder","Substance Use Disorders",[117,118,48,119,120,121,122,123],"Transcranial Direct Current Stimulation","tDCS","Electroencephalography","EEG","Inhibitory Control","Working Memory","Craving","2025-05-28",{"date":126,"type":127},"2025-06-04","ACTUAL",{"date":129,"type":127},"2024-09-23",{"date":131,"type":108},"2027-09-30",{"name":5,"class":6},2]