[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053219":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":36,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":36,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":45,"whyStopped":36,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"The First Affiliated Hospital of Guangzhou Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Modified Mini-PCNL","EXPERIMENTAL","Participants randomized to this arm will undergo 20 Fr modified mini percutaneous nephrolithotomy using the F17 Hawk nephroscope for the treatment of complex renal stones.",[13],"Procedure: 20 Fr Modified Mini Percutaneous Nephrolithotomy",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard PCNL","ACTIVE_COMPARATOR","Participants randomized to this arm will undergo 24 Fr standard percutaneous nephrolithotomy using the F20.8 Wolf nephroscope for the treatment of complex renal stones.",[19],"Procedure: 24 Fr Standard Percutaneous Nephrolithotomy",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","20 Fr Modified Mini Percutaneous Nephrolithotomy","Modified mini percutaneous nephrolithotomy performed with a 20 Fr access sheath and F17 Hawk nephroscope. Stone fragmentation may be performed using pneumatic lithotripsy, Ho:YAG laser, or thulium fiber laser according to the standardized surgical protocol.",[9],[9,27,28],"Modified mPNL","20 Fr Modified Mini-PCNL",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"24 Fr Standard Percutaneous Nephrolithotomy","Standard percutaneous nephrolithotomy performed with a 24 Fr access sheath and F20.8 Wolf nephroscope. Stone fragmentation may be performed using pneumatic lithotripsy, Ho:YAG laser, or thulium fiber laser according to the standardized surgical protocol.",[15],[15,34,35],"sPNL","24 Fr Standard PCNL",null,[38],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},"Yongda Liu, Doctor","CONTACT","+020-83062923","13719007083@163.com",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Guangzhou","Guangdong","510120","China","CN",{"type":52,"coordinates":53},"Point",[54,55],113.25,23.11667,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":41,"phoneExt":36,"email":42},"Yongda Liu",{"type":61,"investigatorFullName":59,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Professor and Director, Department of Urology","100053219","modified-mini-pcnl-versus-standard-pcnl-for-complex-kidney-stones-100053219",false,"NCT07697677","Modified Mini-PCNL Versus Standard PCNL for Complex Kidney Stones","Modified Mini Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for the Treatment of Complex Renal Calculi: A Multicenter Randomized Controlled Trial","MIMIC-PCNL","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Serum creatinine ≤133 μmol\u002FL.\n3. American Society of Anesthesiologists (ASA) physical status classification I-III.\n4. S.T.O.N.E. score ≥8.\n5. Complex renal stones confirmed by noncontrast computed tomography, including stone surface area \\>1500 mm², multiple calyceal stones, partial or complete staghorn calculi, or complex anatomical conditions.\n6. Patients who provide written informed consent and agree to undergo either modified mini-percutaneous nephrolithotomy or standard percutaneous nephrolithotomy.\n\nExclusion Criteria:\n\n1. Solitary kidney.\n2. Morbid obesity (body mass index ≥35 kg\u002Fm²).\n3. Previous renal transplantation or urinary diversion.\n4. Congenital abnormalities of the urinary tract.\n5. Pregnancy.\n6. Uncorrected coagulopathy.\n7. Active urinary tract infection.","ALL","18 Years","70 Years",{"count":75,"type":76},1380,"ESTIMATED","INTERVENTIONAL",[79],"NA","Kidney stones that are large or complex are often treated with percutaneous nephrolithotomy, also called PCNL. Standard PCNL uses a larger access tract and is effective for removing complex kidney stones, but it may be associated with more bleeding, pain, and recovery burden. Modified mini-PCNL uses a smaller access tract and may reduce surgical trauma while maintaining a similar stone clearance rate.\n\nThis multicenter randomized trial will compare modified mini-PCNL using a 20 Fr access sheath with standard PCNL using a 24 Fr access sheath in adults with complex renal stones. About 1,380 participants from 8 urology centers will be randomly assigned to receive one of the two procedures. The main purpose of the study is to determine whether modified mini-PCNL is not worse than standard PCNL in achieving stone-free status shortly after surgery. Stone-free status will be assessed by low-dose noncontrast CT within 72 hours after surgery. The study will also compare stone-free status at 3 months, complications, operation time, length of hospital stay, need for additional procedures, and quality of life.",[82,83],"Kidney Stones","Complex Renal Calculi",[85,86,15,9,87,88,89],"Percutaneous Nephrolithotomy","Mini-PCNL","Complex Renal Stones","Stone-Free Rate","Randomized Controlled Trial","2026-07-07",{"date":92,"type":93},"2026-07-13","ACTUAL",{"date":95,"type":76},"2026-07-15",{"date":97,"type":76},"2027-09-14",{"name":5,"class":6},1]