[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100506878":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":80,"collaborators":82,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":95,"minAge":26,"maxAge":96,"enrollmentInfo":97,"targetDuration":26,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Weight Loss","EXPERIMENTAL","Participants will be asked to participate in a 1x\u002Fweek center-based or tele-health nutrition diet class, 2x\u002Fweek center-based exercise classes, and 1x\u002Fweek exercise session conducted on their own for approximately 12 weeks.",[13],"Behavioral: 12-weeks of Weight Loss",{"label":15,"type":16,"description":17,"interventionNames":18},"Weight Stability","ACTIVE_COMPARATOR","Participants will be asked to participate in a 1x\u002Fweek center-based or tele-health education class, 2x\u002Fweek center-based or tele-health stretching\u002Fbalance classes, and 1x\u002Fweek stretching\u002Fbalance session conducted on their own for approximately 12 weeks.",[19],"Behavioral: 12-weeks of Weight Stability",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","12-weeks of Weight Loss","Participants will be asked to participate in a 1x\u002Fweek center-based or tele-health nutrition diet class, 2x\u002Fweek center-based exercise classes, and 1x\u002Fweek exercise session conducted on their own for \\~12 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"12-weeks of Weight Stability","Participants will be asked to participate in a 1x\u002Fweek center-based or tele-health education class, 2x\u002Fweek center-based stretching\u002Fbalance classes, and 1x\u002Fweek stretching\u002Fbalance session conducted on their own for \\~12 weeks.",[15],[32],{"name":33,"affiliation":34,"role":35},"Alice S. Ryan, PhD","Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Kristina Marcus, MS","CONTACT","(410) 605-7000","kristina.marcus@va.gov",[43,60],{"facility":34,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-76.61219,39.29038,{"lat":54,"lon":53},[57,59],{"name":38,"role":39,"phone":58,"phoneExt":26,"email":41},"410-605-7000",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":61,"status":44,"city":62,"state":63,"zip":64,"country":48,"countryCode":49,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"South Texas Health Care System, San Antonio, TX","San Antonio","Texas","78229-4404",{"type":51,"coordinates":66},[67,68],-98.49363,29.42412,{"lat":68,"lon":67},[71,75],{"name":72,"role":39,"phone":73,"phoneExt":26,"email":74},"Tiffany Cortes, MD","814-332-9939","tiffany.cortes@va.gov",{"name":76,"role":39,"phone":77,"phoneExt":78,"email":79},"Tim Calderon, MS","2106175300","13898","tim.calderon@va.gov",{"type":81,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[83,85],{"name":84,"class":6},"Baltimore VA Medical Center",{"name":86,"class":6},"South Texas Veterans Health Care System","100506878","modifying-adiposity-through-behavioral-strategies-to-improve-covid-19-rehabilitation-100506878",false,"NCT05880108","Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation","MARVEL","Inclusion Criteria:\n\n1. U.S. Veteran\n2. Self-reported COVID-19 naïve or COVID-19 \\> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \\>4 weeks)\n3. Body Mass Index: 19-25 or 30-50 kg\u002Fm2\n\nExclusion Criteria:\n\n1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments\n2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \\> 2.5 x WNL), renal (eGFR\\\u003C45), gastrointestinal, malignant, and psychiatric disease\n3. Uncontrolled diabetes (HbA1c \\>10% or the current use of insulin)\n4. Weight change within the past month of \\>5 kg\n5. Self-reported alcohol or drug abuse\n6. Anti-coagulant medication usage",true,"ALL","80 Years",{"count":98,"type":99},150,"ESTIMATED","INTERVENTIONAL",[102],"NA","The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.",[105,106],"Post-COVID Conditions","Obesity",[108,106,109,9,110],"COVID-19","Senescence","Exercise","2026-05-27",{"date":113,"type":114},"2026-06-01","ACTUAL",{"date":116,"type":114},"2024-06-03",{"date":118,"type":99},"2029-09-30",{"name":5,"class":6},2]