[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622194":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":34,"locations":44,"responsibleParty":95,"collaborators":99,"id":103,"slug":104,"hasResults":105,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":105,"sex":111,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":33,"studyType":117,"phases":118,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":47,"whyStopped":33,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Pontificia Universidad Catolica de Chile","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Modular Psychotherapy (MIND)","EXPERIMENTAL","Participants assigned to the MIND arm receive a personalized modular psychotherapy designed for depression complicated by personality dysfunction and\u002For complex trauma. All participants receive a core evidence-based depression treatment, including behavioral activation, cognitive, and interpersonal psychotherapy strategies. Additional short therapy modules are selected and added based on each participant's baseline emotional and interpersonal functioning profile following a module assignment algorithm. These modules target specific areas: emotion regulation difficulties, sensitivity to rejection and interpersonal threat, social functioning problems. Treatment is delivered as weekly individual psychotherapy sessions, with the number and combination of modules tailored to individual clinical needs.",[13],"Behavioral: Modular Intervention for Depression Therapy (MIND Therapy)",{"label":15,"type":16,"description":17,"interventionNames":18},"Treatment as Usual (TAU)","ACTIVE_COMPARATOR","Participants assigned to the treatment as usual (TAU) arm receive individual psychotherapy as typically provided in public community mental health centers in Chile. This treatment reflects routine clinical practice and may vary in therapeutic approach according to the therapist's usual orientation. Sessions are delivered individually and on a weekly basis, without the use of the modular psychotherapy protocol.",[19],"Behavioral: Psychotherapy as Usual (TAU)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Modular Intervention for Depression Therapy (MIND Therapy)","The MIND intervention is an algorithm-based, personalized, modular psychotherapy for adults with depression complicated by personality dysfunction and\u002For complex trauma. All participants receive a core evidence-based depression treatment that includes behavioral activation, cognitive, and interpersonal psychotherapy strategies. Additional short therapy modules are selected based on each participant's baseline emotional, interpersonal, and self-related functioning profile, using a predefined clinical algorithm. These modules target specific difficulties such as emotion regulation problems (DBT Module), sensitivity to rejection and interpersonal threat (MBT and CBASP Modules), social functioning difficulties (Social Thinning Module). The type and number of modules are tailored to individual needs following an algorithm based on baseline measures (DERS, A-RSQ, OQ-45-IR). Treatment is delivered as weekly individual psychotherapy sessions.",[9],[27],"Psychotherapy",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Psychotherapy as Usual (TAU)","Psychotherapy as usual (TAU) consists of individual psychotherapy delivered in public community mental health centers according to routine clinical practice. Treatment is provided weekly by trained clinicians and may vary in therapeutic orientation, techniques, and structure depending on the therapist and center. TAU is not guided by the modular psychotherapy protocol or algorithm used in the experimental intervention and reflects standard care available in the Chilean public mental health system.",[15],[27],null,[35,40],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Alex J Behn, PhD","CONTACT","+56942152484","albehn@uc.cl",{"name":41,"role":37,"phone":42,"phoneExt":33,"email":43},"Jorge Matamala, Bachelor of Psychology","+56982504691","jmatamale@uc.cl",[45,62,68,77,86],{"facility":46,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"CDT CASR","RECRUITING","Santiago","Chile","CL",{"type":52,"coordinates":53},"Point",[54,55],-70.64827,-33.45694,{"lat":55,"lon":54},[58],{"name":59,"role":37,"phone":60,"phoneExt":33,"email":61},"Director","+56925762330","matiascorrearamirez@gmail.com",{"facility":63,"status":64,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":65,"geoPoint":67,"contacts":33},"COSAM La Bandera","ACTIVE_NOT_RECRUITING",{"type":52,"coordinates":66},[54,55],{"lat":55,"lon":54},{"facility":69,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},"COSAM La Granja",{"type":52,"coordinates":71},[54,55],{"lat":55,"lon":54},[74],{"name":59,"role":37,"phone":75,"phoneExt":33,"email":76},"+5625761806","direccioncosam09@gmail.com",{"facility":78,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"COSAM La Pintana",{"type":52,"coordinates":80},[54,55],{"lat":55,"lon":54},[83],{"name":59,"role":37,"phone":84,"phoneExt":33,"email":85},"+5625457697","cosampintana@gmail.com",{"facility":87,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":88,"geoPoint":90,"contacts":91},"COSAM Rinconada",{"type":52,"coordinates":89},[54,55],{"lat":55,"lon":54},[92],{"name":59,"role":37,"phone":93,"phoneExt":33,"email":94},"+56925412271","cosamrinconada.sanramon@gmail.com",{"type":96,"investigatorFullName":97,"investigatorTitle":98,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Alex Behn","Associate Professor",[100],{"name":101,"class":102},"MIDAP Millennium Institute for Research in Depression and Personality","UNKNOWN","100622194","modular-intervention-for-depression-study-100622194",false,"NCT07380451","Modular Intervention for Depression Study","Modular Optimization of Psychotherapy for Individuals With Depression Complicated by Personality Dysfunction and Complex Trauma: A Pilot Study in the Chilean Public Health System","MIND","Inclusion Criteria:\n\n* Current diagnosis of major depressive disorder, defined as:\n\n  * Positive diagnosis on the MINI diagnostic interview, and\n  * PHQ-9 score greater than 10\n* Evidence of personality dysfunction, defined as a score above the cutoff on the Level of Personality Functioning Scale-Brief Form (LPFS-BF 2.0).\n* History of moderate to severe early life adversity, defined as elevated scores on at least one scale of the Childhood Trauma Questionnaire (CTQ), and\u002For clinically significant alterations in self-organization.\n* Presence of at least one elevated domain of alteration of self-organization, including emotion regulation difficulties, interpersonal sensitivity, and\u002For interpersonal functioning problems, as assessed by standardized self-report measures (DERS, A-RSQ, OQ-45-IR).\n* Receiving care at a participating public community mental health center in Chile.\n* Ownership of a smartphone (Android or iOS) with internet access and an active data plan.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Acute suicide risk requiring immediate intensive intervention, as assessed by the MINI.\n* Any severe psychiatric disorder other than major depressive disorder that is the primary clinical diagnosis, including:\n\n  * Schizophrenia or other psychotic disorders\n  * Bipolar I disorder\n* Severe substance use disorder, active within the past 6 months.\n* Diagnosis of post-traumatic stress disorder (PTSD) meeting full diagnostic criteria, as assessed by standardized instruments (ITEM and ITQ).\n* Meeting diagnostic criteria for:\n\n  * Antisocial personality disorder (two or more criteria), or\n  * Borderline personality disorder with more than three diagnostic criteria\n* Severe medical, cognitive, or psychosocial condition that would interfere with participation in weekly psychotherapy.\n* Concurrent participation in another active psychotherapy or initiation\u002Fchange of psychotropic medication during the study period, except for:\n\n  * Stable antidepressant treatment\n  * Medications prescribed for sleep\n  * Benzodiazepines used only on an as-needed (PRN) basis.\n* Inability to comply with study procedures or assessments.","ALL","18 Years","65 Years",{"count":115,"type":116},150,"ESTIMATED","INTERVENTIONAL",[119],"NA","The goal of this psychotherapy clinical trial is to evaluate whether a algorithm-based personalized modular psychotherapy is more effective than usual individual psychotherapy in treating major depressive disorder complicated by personality dysfunction and\u002For complex trauma in adults aged 18 to 65 receiving care in the Chilean public mental health system.\n\nThe main questions it aims to answer are:\n\n* Does algorithm-based modular psychotherapy lead to greater clinically significant reduction and remission of depressive symptoms compared to usual psychotherapy?\n* Does algorithm-based modular psychotherapy lead to greater improvement in emotional regulation, interpersonal functioning, and self-related functioning, including changes observed in daily life?\n\nResearchers will compare algorithm-based modular psychotherapy to usual individual psychotherapy provided in public community mental health centers to see if the modular, personalized approach results in better clinical outcomes, stronger therapeutic alliance, and higher treatment satisfaction.\n\nParticipants will:\n\n* Be randomly assigned to receive either algorithm-based modular psychotherapy or usual individual psychotherapy\n* Attend weekly individual psychotherapy sessions\n* Complete structured diagnostic interviews and self-report questionnaires before, during, and after treatment\n* Provide brief daily reports on mood, emotions, and interpersonal experiences using a smartphone before and after treatment",[122],"Major Depression",[124,125,126],"Complicated Depression","Early Life Adversity","Personality Dysfunction","2026-05-11",{"date":129,"type":130},"2026-05-12","ACTUAL",{"date":132,"type":116},"2026-05-01",{"date":134,"type":116},"2028-02-28",{"name":5,"class":6},5]