[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510220":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":70,"collaborators":34,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":34,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":34,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":55,"whyStopped":34,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Theta-nested gamma tACS applied during passive task epochs","EXPERIMENTAL","Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during fixation periods between consecutive task trials. EEG will be acquired before and immediately after the intervention.",[13],"Device: Active tACS",{"label":15,"type":10,"description":16,"interventionNames":17},"Theta-nested gamma tACS applied during memory delays","Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. EEG will be acquired before and immediately after the intervention.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Gamma tACS applied during memory delays","Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. The stimulation will be phase locked to the peaks of ongoing theta rhythms of the participant. EEG will be acquired before and immediately after the intervention.",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Placebo tACS applied during task performance","PLACEBO_COMPARATOR","Participants will receive single-session administration of placebo tACS during performance of a working memory task. EEG will be acquired before and immediately after the intervention.",[27],"Device: Placebo tACS",[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Active tACS","Active tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.",[19,15,9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Placebo tACS","Placebo tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.",[23],[40],{"name":41,"affiliation":5,"role":42},"Hamdi Eryilmaz, Ph.D.","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":34,"email":48},"Allyson Smith, B.S.","CONTACT","(617) 726-1040","asmith192@mgh.harvard.edu",{"name":41,"role":46,"phone":50,"phoneExt":34,"email":51},"(617) 643-7462","hamdi.eryilmaz@mgh.harvard.edu",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Martinos Center for Biomedical Imaging","RECRUITING","Charlestown","Massachusetts","02129","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-71.062,42.37787,{"lat":65,"lon":64},[68],{"name":69,"role":46,"phone":34,"phoneExt":34,"email":34},"Alexandra O'Neill, B.S.",{"type":42,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Hamdi Eryilmaz, PhD","Assistant Professor","100510220","modulation-of-brain-oscillations-underlying-working-memory-100510220",false,"NCT05923606","Modulation of Brain Oscillations Underlying Working Memory","State-dependent Modulation of Interactions of Theta and Gamma Rhythms in Working Memory","Inclusion Criteria:\n\n* Able to provide informed consent\n* Fluent in English.\n\nExclusion Criteria:\n\n* History of a neurological\u002Fpsychiatric disorder\n* Current use of psychotropic medications\n* Current use of substances and drugs that were shown to affect tES (transcranial electrical stimulation) efficacy (dopamine altering drugs, nicotine, NMDA (N-methyl-D-aspartate) antagonists\u002Fagonists, sodium\u002Fcalcium channel blockers, norepinephrine reuptake inhibitors, GABAergic modulators and selective serotonin reuptake inhibitors)\n* Contraindications for tACS (e.g., history of seizures, metallic implants in the head or neck, implanted brain stimulators, vagus nerve stimulators, pacemakers, pregnancy)",true,"ALL","18 Years","35 Years",{"count":85,"type":86},32,"ESTIMATED","INTERVENTIONAL",[89],"NA","This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.",[92],"Working Memory",[94,95,96,97],"Working memory","Attention","Theta oscillations","Transcranial Alternating Current Stimulation","2026-02-06",{"date":100,"type":101},"2026-02-09","ACTUAL",{"date":103,"type":101},"2024-07-10",{"date":105,"type":86},"2027-03-31",{"name":5,"class":6},1]