[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586452":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":43,"centralContacts":47,"locations":53,"responsibleParty":69,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":95,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Hospital HM Nou Delfos","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Opioid-Free Anesthesia (OFA)",null,"Patients in this group will receive opioid-free anesthesia (OFA) using a multimodal analgesic approach, including dexmedetomidine, lidocaine, ketamine, and magnesium sulfate. No intraoperative opioids will be administered. Inflammatory biomarkers (IL-6, PCR, cortisol, WBC, VSG) and heart rate variability (HRV) will be measured to assess the inflammatory response.",[13],"Procedure: Opioid-Free Anesthesia (OFA)",{"label":15,"type":10,"description":16,"interventionNames":17},"Opioid-Based Anesthesia - Intravenous (OBA-IV)","Patients in this group will receive opioid-based intravenous anesthesia (OBA-IV) with propofol, remifentanil, and neuromuscular blockade. Standard opioid-based analgesia will be administered intraoperatively. Inflammatory biomarkers (IL-6, PCR, cortisol, WBC, VSG) and HRV will be assessed to compare inflammatory responses between opioid-based and opioid-free techniques.",[18],"Procedure: Opioid-Based Intravenous Anesthesia (OBA-IV)",{"label":20,"type":10,"description":21,"interventionNames":22},"Opioid-Based Anesthesia - Inhalational (OBA-Inh)","Patients in this group will receive opioid-based inhalational anesthesia (OBA-Inh) using sevoflurane, remifentanil, and neuromuscular blockade. Standard opioid-based analgesia will be used intraoperatively. Inflammatory biomarkers (IL-6, PCR, cortisol, WBC, VSG) and HRV will be analyzed to evaluate differences in the inflammatory response among the three anesthetic techniques.",[23],"Procedure: Opioid-Based Inhalational Anesthesia (OBA-Inh)",[25,31,37],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Opioid-free anesthesia using a multimodal approach, including dexmedetomidine, lidocaine, ketamine, and magnesium sulfate. No intraoperative opioids are administered.",[9],[30],"Multimodal Opioid-Free Anesthesia",{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Opioid-Based Intravenous Anesthesia (OBA-IV)","Standard opioid-based intravenous anesthesia using propofol, remifentanil, and neuromuscular blockade.",[15],[36],"IV Opioid-Based Anesthesia",{"type":26,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Opioid-Based Inhalational Anesthesia (OBA-Inh)","Standard opioid-based inhalational anesthesia using sevoflurane, remifentanil, and neuromuscular blockade.",[20],[42],"Inhalational Opioid-Based Anesthesia",[44],{"name":45,"affiliation":5,"role":46},"Gregory Contreras-Pérez, Anesthesiologist","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},"Hipolito Labandeyra Gonzalez, Anesthesiologist","CONTACT","+34696055181","hipolitolabandeyra@gmail.com",[54],{"facility":5,"status":55,"city":56,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Barcelona","08023","Spain","ES",{"type":61,"coordinates":62},"Point",[63,64],2.15899,41.38879,{"lat":64,"lon":63},[67,68],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},{"name":45,"role":46,"phone":10,"phoneExt":10,"email":10},{"type":46,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"HIPÓLITO LABANDEYRA GONZALEZ","Anesthesiologist","100586452","modulation-of-the-inflammatory-response-in-bariatric-surgery-100586452",false,"NCT06915558","Modulation of the Inflammatory Response in Bariatric Surgery","Modulation of the Inflammatory Response to Surgical Trauma: Comparison of Three Anesthetic Techniques in Bariatric Surgery Patients","MRICBx3","Inclusion Criteria:\n\n* Patients scheduled for bariatric surgery.\n* Age 18-65 years.\n* BMI ≥ 30 kg\u002Fm².\n* ASA physical status II-III.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Chronic opioid use before surgery.\n* Severe renal or hepatic failure.\n* Uncontrolled psychiatric disorders.\n* Significant intraoperative complications requiring protocol deviation.","ALL","18 Years","65 Years",{"count":84,"type":85},90,"ESTIMATED","OBSERVATIONAL","This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids.\n\nThe study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response.\n\nThe results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.",[89,90,91,92,93,94],"Obesity","Bariatric Surgery Candidate","Inflammation","Postoperative Pain","Opioid-Free Anesthesia","Heart Rate Variability",[93,96,97,98,99],"Opioid-Based Anesthesia","Inflammatory Markers","Surgical Stress Response","heart rate variability","2025-04-04",{"date":102,"type":103},"2025-04-08","ACTUAL",{"date":105,"type":103},"2024-12-02",{"date":107,"type":85},"2025-12-02",{"name":5,"class":6},1]