[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539465":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":64,"collaborators":18,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":18,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":18,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":18,"overallStatus":30,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Meyer Children's Hospital IRCCS","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients with suspected diagnostic onco-hematologic\u002Fimmunologic disease","All patients with suspected diagnostic onco-hematologic, onco-immunologic, and hematologic disease at onset or relapse.\n\nPatients undergo several procedures to complete the diagnostic process and eventually the staging of the disease",[12],"Other: Analysis of biological samples",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Analysis of biological samples","The collected biological sample will be isolated and the specific nucleic acid (DNA\u002FRNA\u002FcfDNA) extracted for molecular analysis for understanding the reproducibility of the analysis and thus the feasibility of centralization:\n\n* hot spot on DNa (ddPCR\u002FSanger)\n* fusion genes on RNA (target resequencing)\n* Known mutation analysis by liquid biopsy (cfDNA) for somatic mutations with a mutation frequency of less than 10%\n* Tumor type-associated gene sequence analysis by Sanger sequencing and NGS",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Marinella Veltroni","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","0555662606","marinella.veltroni@meyer.it",[29,42,53],{"facility":5,"status":30,"city":31,"state":18,"zip":18,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Florence","Italy","IT",{"type":35,"coordinates":36},"Point",[37,38],11.24626,43.77925,{"lat":38,"lon":37},[41],{"name":21,"role":25,"phone":18,"phoneExt":18,"email":27},{"facility":43,"status":30,"city":44,"state":18,"zip":18,"country":32,"countryCode":33,"cosmosGeoPoint":45,"geoPoint":49,"contacts":50},"Azienda Ospedaliero-Universitaria Pisana","Pisa",{"type":35,"coordinates":46},[47,48],10.4036,43.70853,{"lat":48,"lon":47},[51],{"name":52,"role":25,"phone":18,"phoneExt":18,"email":18},"Gabriella Casazza",{"facility":54,"status":30,"city":55,"state":18,"zip":18,"country":32,"countryCode":33,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Azienda Ospedaliero-Universitaria Senese","Siena",{"type":35,"coordinates":57},[58,59],11.33064,43.31822,{"lat":59,"lon":58},[62],{"name":63,"role":25,"phone":18,"phoneExt":18,"email":18},"Salvatore Grosso",{"type":22,"investigatorFullName":21,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Principal Investigator","100539465","molecular-characterizazion-and-biological-samples-centralisation-of-patients-affected-by-oncoematolofic-pathology-100539465",false,"NCT06304194","Molecular Characterizazion and Biological Samples Centralisation of Patients Affected by Oncoematolofic Pathology","Pilot Study to Assess the Feasibility of Centralizing Biological Samples at Onset and Relapse of Patients Referred to CROP Centers for Molecular Characterization of Oncohematologic Pathology","Inclusion Criteria:\n\n* Diagnostic suspicion of oncologic, hematologic or onco-immunologic disease\n* Suspected recurrence of oncological, onco-hematological, hematological or onco -immunological disease\n* Availability of biological material\n* Signature of informed consent\n* Age between 0 and 30 years\n\nExclusion Criteria:\n\n* Failure to sign the consent\n* Insufficiency of biological material for analysis\n* Patients with HIV, HCV and HBV seropositivity (HBSAg) due to biohazard and bias related to patients' immunological status that could influence gene expression and tumor behavior.","ALL","0 Years","30 Years",{"count":77,"type":78},340,"ESTIMATED","INTERVENTIONAL",[81],"NA","Currently, the molecular characterization of onco-hematological, onco-immunological and hematological diseases, at onset or in relapse, of patients with suspected diagnosis afferent to the CROP centers, is done through centralization of biological samples at reference laboratories outside the Tuscany Region.\n\nIn order to preserve the wealth of clinical and biological data and use it for the benefit of present and future patients treated at the CROP centers, it is useful to evaluate the feasibility of centralization and molecular typing of mutations present in tumor tissue at the IRCCS AOU Meyer Oncohematology Laboratories and subsequently the analysis of clinical data from patients with diseases not under study to lay the foundations of a translational database that can then be associated with a biobank in the future.\n\nThis will enable a targeted contribution to pediatric oncohematology research, investing in possible targeted therapies with those patient subgroups that benefit from personalized disease assessment in mind. The goal of the project is to improve the regional infrastructure dedicated to organized data collection and management of biological samples in adequate time resulting in better and more comprehensive data collection.",[84,85],"Oncologic Disease","Hematologic Diseases","2024-03-04",{"date":88,"type":89},"2024-03-12","ACTUAL",{"date":91,"type":89},"2023-07-05",{"date":93,"type":78},"2028-07-05",{"name":5,"class":6},3]