[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520536":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":10,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"University Hospital, Brest","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Non applicable",null,[12],"Other: Additional blood sampling",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Additional blood sampling","Once you have been informed and have given your consent, 2 tubes of venous blood (citrated tubes of approximately 5 milliliters (ml) each) will be taken after the blood donation to enable in vitro thrombus formation. The entire sample will be used, and no surplus will be kept in the bank.",[9],[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Philippe ROBIN","CONTACT","+33(0)298223327","philippe.robin@chu-brest.fr",[25],{"facility":26,"status":27,"city":28,"state":10,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Etablissement francais du sang","RECRUITING","Brest","29200","France","FR",{"type":33,"coordinates":34},"Point",[35,36],-4.48628,48.39029,{"lat":36,"lon":35},[39],{"name":40,"role":21,"phone":41,"phoneExt":10,"email":10},"Jean-Baptiste THIBERT","02.98.22.33.27",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100520536","molecular-imaging-of-active-venous-thrombus-with-positron-emission-tomography-pet-100520536",false,"NCT06057844","Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)","THROMPET","Inclusion Criteria:\n\nMajor patient (≥18 years), voluntary blood donor, with no notable medical history altering coagulation (i.e. known thrombophilia, active cancer), no chronic pathology, no current treatment.\n\nExclusion Criteria:\n\nMinor patient (\\\u003C18 years); known chronic pathology; long-term treatment including anti-platelet aggregation therapy or anticoagulant treatment, refusal to participate.",true,"ALL","18 Years",{"count":55,"type":56},10,"ESTIMATED","INTERVENTIONAL",[59],"NA","Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and\u002For pulmonary embolism (PE), is a major public health issue. VTE is the third most common acute cardiovascular pathology, after myocardial infarction and stroke.\n\nDiagnostic accuracy is essential in the case of VTE, in order to select patients for whom anticoagulant treatment is necessary, and to avoid long-term treatment of patients who will derive no benefit from it.\n\nThe management of patients with suspected PE is based on diagnostic strategies that use either ventilation-perfusion planar lung scintigraphy or thoracic angioscanner imaging as the cornerstone. These 2 techniques correspond to what might be termed \"negative\" imaging, i.e. visualization of the vascular repercussions downstream of an obstruction, whatever its nature.\n\nA research prospect in the field of VTE diagnosis is the direct marking of the various elements of the active venous thrombus, which could correspond to \"positive\" thrombus imaging.\n\nNumerous studies have already investigated the role of molecular imaging in the diagnosis of VTE, especially in the diagnosis of DVT. However, these studies used conventional scintigraphy to evaluate these tracers, a technique lacking in sensitivity and with insufficient spatial resolution.\n\nNuclear medicine and molecular imaging have undergone a technological revolution since the early 2000s, with the development of positron emission tomography (PET). The technical advantages of PET over conventional scintigraphy include greater sensitivity and higher spatial resolution (4 mm for PET vs. 12 mm for conventional scintigraphy), which may have been the limiting factor in studies already carried out.\n\nThe aim of this project is to develop a new radiopharmaceutical for use in PET scans, a biomarker of active venous thrombus, with a view to improving the diagnosis of MVTE and hence patient management.",[62],"Venous Thromboembolism (VTE)","2026-06-05",{"date":65,"type":66},"2026-06-08","ACTUAL",{"date":68,"type":66},"2024-02-27",{"date":70,"type":56},"2026-08-28",{"name":5,"class":6},1]