[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623223":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":22,"responsibleParty":43,"collaborators":7,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":7,"enrollmentInfo":55,"targetDuration":7,"studyType":58,"phases":7,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"VO Health, Inc.","INDUSTRY",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"OTHER","There is no intervention.","The investigators are not administering an intervention for this study. To opportunistically capture prospective data, the investigators give participants the option for re-testing after a period of time where participants are undergoing a self-directed intervention (i.e., no influence of the research staff), such as training for a marathon or other fitness event.",[14,19],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Brooks P Leitner, MD, PhD","CONTACT","443-474-7206","brooks@vohealth.co",{"name":20,"role":16,"phone":7,"phoneExt":7,"email":21},"Sean P Langan, PhD","sean@vohealth.co",[23],{"facility":5,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"RECRUITING","New Haven","Connecticut","06510","United States","US",{"type":31,"coordinates":32},"Point",[33,34],-72.92816,41.30815,{"lat":34,"lon":33},[37,38,39,41],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},{"name":20,"role":16,"phone":7,"phoneExt":7,"email":21},{"name":15,"role":40,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"name":20,"role":42,"phone":7,"phoneExt":7,"email":7},"SUB_INVESTIGATOR",{"type":44,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100623223","molecular-indicators-of-systematic-fitness-100623223",false,"NCT07393841","Molecular Indicators of Systematic Fitness","MISFIT","Inclusion Criteria:\n\n* Be ≥18 years old\n* Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)\n* Be willing to complete VO₂max testing, blood draw, and questionnaires.\n* Be able to safely perform maximal\u002Fsymptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)\n\nExclusion Criteria:\n\n* Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)\n* Contraindications or unwillingness to undergo venipuncture\n* Acute illness (fever, significant respiratory illness) at the time of testing\n* Failure to comply with procedures.",true,"ALL","18 Years",{"count":56,"type":57},250,"ESTIMATED","OBSERVATIONAL","The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max\u002FVO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max\u002FVO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:\n\n1. Can a multi-analyte blood panel accurately predict directly measured VO₂max\u002FVO₂peak?\n2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles?\n3. Are the predictor analytes able to capture changes in VO₂max\u002FVO₂peak caused by a self-directed intervention (e.g., training for a marathon)?\n4. What is the analytic reliability of the predictor biomarkers?",[61,62,63,64,65,66],"Healthy Adult","Fitness Testing","Athlete","Aging","Exercise Physiology","Human Performance",[68,69,70,71,72,73,74,75,76],"VO2peak","VO2max","cardiorespiratory fitness","proteomics","blood biomarkers","cardiovascular health","oxygen transport","exercise performance","functional capacity","2026-02-02",{"date":79,"type":80},"2026-02-06","ACTUAL",{"date":82,"type":80},"2026-01-05",{"date":84,"type":57},"2028-05-10",{"name":5,"class":6},1]