[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605097":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":26,"locations":31,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":10,"maxAge":10,"enrollmentInfo":63,"targetDuration":66,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart Failure with reduced ejection fraction (HFrEF)",null,"LVEF \\\u003C40%",{"label":13,"type":10,"description":14,"interventionNames":10},"Heart Failure with preserved ejection fraction (HFpEF)","LVEF \\>50%",{"label":16,"type":10,"description":17,"interventionNames":10},"Heart Failure with mildyly reduced ejection fraction (HFmrEF)","LVEF \\>40% and \\\u003C50%",[19,23],{"name":20,"affiliation":21,"role":22},"Jan A Kleeberger, MD","Universitätsspital Zürich","PRINCIPAL_INVESTIGATOR",{"name":24,"affiliation":5,"role":25},"Francesco Paneni, MD, PhD","STUDY_DIRECTOR",[27],{"name":20,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","+41763220376","janalphard.kleeberger@usz.ch",[32],{"facility":33,"status":10,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":39,"coordinates":40},"Point",[41,42],8.55,47.36667,{"lat":42,"lon":41},[45,46,47,48],{"name":20,"role":28,"phone":29,"phoneExt":10,"email":30},{"name":10,"role":28,"phone":10,"phoneExt":10,"email":30},{"name":20,"role":22,"phone":10,"phoneExt":10,"email":10},{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Ludovica Di Venanzio, MD","SUB_INVESTIGATOR",{"type":22,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jan Kleeberger","Principal Investigator","100605097","molecular-underpinnings-of-heart-failure-integrative-multi-omics-and-non-coding-rna-profiling-100605097",false,"NCT07158086","Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling","Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling: the BIOCARDIUM-HF Study","BIOCARDIUM-HF","INCLUSION CRITERIA\n\n* Female and Male, age ≥18 years at screening.\n* Diagnosis of Heart Failure according to ESC Heart Failure Guidelines\n* Ability to understand the requirements of the study and to provide informed consent.\n* Willingness to undergo follow-up.\n\nEXCLUSION CRITERIA\n\nPatients will be excluded if they meet any of the following conditions:\n\n* Active malignancy or history of cancer with ongoing treatment (e.g., chemotherapy, radiotherapy, immunotherapy).\n* Autoimmune or systemic inflammatory diseases.\n* Concomitant infections, including acute systemic infections (e.g., sepsis, pneumonia) or chronic infections with systemic impact (e.g., HIV, hepatitis B\u002FC with elevated transaminases).\n\nOther exclusion criteria:\n\n* Age\\\u003C18 years old\n* Inability to provide written informed consent","ALL",{"count":64,"type":65},500,"ESTIMATED","5 Years","OBSERVATIONAL","The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling. By integrating clinical data with cutting-edge multi-omics techniques (including transcriptomics, epigenomics, and proteomics), this research aims to identify molecular signatures, particularly non-coding RNAs (ncRNAs), that are linked to the onset and progression of HF. Through advanced molecular profiling of biological samples and the analysis of clinical parameters, including advanced imaging, hemodynamic profiling, and biomarker analysis, the study will contribute to the deep phenotyping of HF patients.\n\nThe secondary objective aims to uncover potential biomarkers that may serve as predictive indicators of disease progression and identify novel therapeutic targets, offering promising avenues for future treatments in this challenging patient population.",[70,71],"Heart Failure","Heart Failure (for Example, Fluid Overload)","NOT_YET_RECRUITING","2025-09-09",{"date":75,"type":76},"2025-09-10","ACTUAL",{"date":78,"type":65},"2025-11-01",{"date":80,"type":65},"2031-11-30",{"name":5,"class":6},1]