[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606620":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":20,"responsibleParty":32,"collaborators":20,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":20,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":64,"whyStopped":20,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":20},{"fullName":5,"class":6},"Peking University Cancer Hospital & Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: Monarch RAB + CBCT-guided ICG Localization + VATS Sublobectomy","EXPERIMENTAL","All participants will undergo preoperative localization of small pulmonary nodules using indocyanine green (ICG) mixed with iodinated contrast agent under Monarch Robotic Assisted Bronchoscopy (RAB) with Cone-Beam CT (CBCT) guidance, performed by a single surgeon without prior RAB localization experience. Immediately after localization, patients will undergo video-assisted thoracoscopic surgery (VATS) sublobectomy (wedge resection or segmentectomy).",[13],"Procedure: Monarch RAB with CBCT-guided ICG Dye Marking",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Monarch RAB with CBCT-guided ICG Dye Marking","Under general anesthesia, the Monarch RAB platform is used to navigate to the target bronchus. With CBCT confirmation, 0.25 ml of ICG (0.2 mg\u002Fml) mixed with 0.25 ml iodinated contrast is injected within 1 cm of the nodule. The dye marking is identified intraoperatively with near-infrared light to guide VATS sublobectomy.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Shaohua Ma","Peking University Cancer Hospital & Institute, Beijing 100142, China","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Bingyang Huang","CONTACT","+8613161541915","bingyanghuang@outlook.com",{"type":33,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100606620","monarch-robotic-bronchoscopy-for-lung-nodule-icg-dye-marking-before-vats-100606620",false,"NCT07177924","Monarch Robotic Bronchoscopy for Lung Nodule ICG Dye Marking Before VATS","Effectiveness, Safety and Learning Curve of Monarch Robotic Assisted Bronchoscopy for Lung Nodule ICG Dye Marking Before VATS Sublobectomy","REALM","Inclusion Criteria:\n\n* Age 18-80 years\n* Clinically indicated sub-lobar resection\n* Tolerates general anesthesia\n* Single\u002Fmultiple small nodules \\\u003C20 mm in peripheral lung field\n* Nodules difficult to locate intraoperatively by inspection\u002Fpalpation\n\nExclusion Criteria:\n\n* Contraindications to bronchoscopy\u002Fanesthesia\n* Coagulopathy or bleeding tendency\n* Implanted devices interfering with navigation\n* Allergy to ICG or iodinated contrast\n* Pregnant\u002Flactating women\n* Intraoperative findings not suitable for procedure","ALL","18 Years","80 Years",{"count":46,"type":47},50,"ESTIMATED","INTERVENTIONAL",[50],"NA","This is a single-center, prospective, single-arm clinical study conducted at Beijing Cancer Hospital to evaluate the effectiveness, safety, and learning curve of preoperative indocyanine green (ICG) dye marking mixed with iodinated contrast agent under Monarch Robotic Assisted Bronchoscopy (RAB) with Cone-Beam CT (CBCT) for small pulmonary nodules that are difficult to locate during video-assisted thoracic surgery (VATS) sublobectomy. Eligible patients will undergo RAB localization immediately followed by VATS in the same operative session. The primary endpoints include the success rate of localization, effective localization, and VATS sublobar resection. Secondary endpoints include navigation success rate, operation times, reaching depth, complication rates, and health economic outcomes. The learning curve will be analyzed using the cumulative sum (CUSUM) method. A total of 50 patients will be enrolled and followed up for 14 days postoperatively.",[53,54,55,56],"Small Pulmonary Nodules","Pulmonary Nodule Localization","Lung Cancer (Suspected or Confirmed)","Video-assisted Thoracoscopic Surgery (VATS)",[58,59,60,61,62,63],"Robotic Assisted Bronchoscopy","Monarch Platform","Lung Nodule Localization","Video-Assisted Thoracoscopic Surgery (VATS)","Pulmonary Nodules","Lung Cancer Surgery","NOT_YET_RECRUITING","2025-09-10",{"date":67,"type":68},"2025-09-17","ACTUAL",{"date":70,"type":47},"2025-10-10",{"date":72,"type":47},"2026-05-30",{"name":5,"class":6}]