[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633523":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":22,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":22,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":46,"whyStopped":22,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Örebro University, Sweden","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Assessment of Daily Variability in Exposomics and Metabolomics and Associated Metabolic Responses to","EXPERIMENTAL","Participants will be screened before the study, and eligible individuals will begin at week +1. They will receive 52 microsampling kits to collect daily finger-prick blood samples before breakfast for 28 days, along with a wearable device to monitor sleep, stress, and physical activity.\n\nOnce per week, participants will record one habitual weekday lunch and collect additional blood samples at 15 min, 30 min, 1 h, 2 h, and 4 h after the meal, using a portable capillary glucose meter to measure glucose levels before and after eating.\n\nIn total, each participant will collect 52 blood microsamples over 28 days (28 fasting and 24 postprandial). Questionnaires on diet, exposures, food response, and physical activity will be completed at the start (day 0), mid-point (\\~day 14), and end (day 28) of the study.",[13,14,15],"Dietary Supplement: Burger","Device: Daily blood microsampling","Device: Daily glucose monitoring",[17,23,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIETARY_SUPPLEMENT","Burger","Each week, participants will eat one burger and collect finger blood before adn after consuming the burger 15 min, 30 min, 60 min, 120 min, 240 min",[9],null,{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"DEVICE","Daily blood microsampling","Finger-prick will be performed using a disposable pressure-activated lancet (Sterilance Press II, Vitrex; 21G, 2.8 mm incision) on which the lancet cannot be reactivated, and it returns to a safe plastic compartment after puncture. This mechanism reduces biohazard risks and risk of needlestick injuries. The finger-prick blood samples will be collected using a Capitainer quantitative dry blood spot (qDBS) micro sampling device (Capitainer). The total amount of blood obtained per time will be 20 - 100 µL. The micro sampling device has two inlet ports, and when a drop of blood encounters the inlet port of the device, blood flows by capillary forces in a microchannel and 10 -50 µL of blood is absorbed in a pre-perforated paper disk. This principle allows the collection of a fixed volume of blood and overcomes the hematocrit bias.\n\nMetabolite in microsamples will be extracted and analyzed using LC-MS platforms",[9],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":22},"Daily glucose monitoring","An automatic glucose readings will be attached to participant to monitor daily glucose levels. Data will be acquired by the sensor and shared with the researcher",[9],[33],{"name":34,"affiliation":35,"role":36},"Matej Oresic, Ph.D.","School of Medical Sciences, Orebro University","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},"Anh Hoang Nguyen, Ph.D.","CONTACT","+46723747116","anh-hoang.nguyen@oru.se",[44],{"facility":45,"status":46,"city":47,"state":22,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"School of Medical Sciences","RECRUITING","Örebro","70281","Sweden","SE",{"type":52,"coordinates":53},"Point",[54,55],15.2066,59.27412,{"lat":55,"lon":54},[58,59],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},{"name":34,"role":36,"phone":22,"phoneExt":22,"email":22},{"type":36,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Matej Oresic","Professor","100633523","monitoring-changes-in-blood-circulating-metabolites-using-minimally-invasive-techniques-100633523",false,"NCT07527793","Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques","MicroFastFood","Inclusion Criteria:\n\n1. Age: 18-65 years old\n2. Body Mass Index (BMI): 18.5-29.9 kg\u002Fm2\n3. Weight stability within the previous 3 months (self-reported).\n4. Positive intention to maintain usual routine physical activity and eating habits during the study.\n\nExclusion Criteria:\n\n1. Presence of acute chronic diseases, inflammatory or functional gastrointestinal disorders, or any diagnosed disease condition that disrupt daily routine activities.\n2. Routine use medications or supplements that could potentially interfere with the study outcomes\n3. History of eating disorder\n4. Recent use of antibiotic medication within the last 3 months prior to the first visit\n5. Active efforts to lose weight\n6. Smoking\n7. Consumption of alcoholic drinks exceeding nine standard cups per week and\u002For more than three standard cups per occasion",true,"ALL","18 Years","65 Years",{"count":75,"type":76},35,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study investigates short-term intra- and inter-individual variability in human blood metabolism under real-life conditions. Using minimally invasive finger-prick blood sampling, dietary records, and wearable devices, we will longitudinally monitor blood-circulating metabolites and glucose levels in healthy individuals over a four-week period without dietary or lifestyle intervention. The study focuses on metabolic transitions between pre- and postprandial states during habitual daily activities and routine meals. Mass spectrometry-based metabolomics will be used to characterize metabolite profiles and their associations with diet, physical activity, sleep, and stress. In parallel, the study evaluates the feasibility of microsampling approaches, wearable-derived physiological data, and isotope-labelled standards for robust and cost-effective metabolite quantification. The results will inform the design of larger longitudinal studies using minimally invasive blood sampling in non-controlled settings.",[82],"Healthy Participants",[84],"Metabolomics, lipidomics, mass spectrometry, microsampling","2026-04-07",{"date":87,"type":88},"2026-04-14","ACTUAL",{"date":90,"type":88},"2026-01-21",{"date":92,"type":76},"2026-12-31",{"name":5,"class":6},1]