[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559651":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":59,"collaborators":61,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":10,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Shanghai General Hospital, China","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Severe pneumonia",null,"Patients clinically diagnosed as severe pneumonia are diagnosed according to the Guidelines for the diagnosis and Treatment of community-acquired pneumonia in Adults (2019 edition) formulated by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA), who meet 1 of the following major criteria or ≥3 minor criteria can be diagnosed. The diagnostic criteria for severe pneumonia in children were adopted by the British Thoracic Society (BTS) in 2011.",{"label":13,"type":10,"description":14,"interventionNames":10},"Mild pneumonia","Patients clinically diagnosed as severe pneumonia and mild pneumonia are diagnosed according to the Guidelines for the diagnosis and Treatment of community-acquired pneumonia in Adults (2019 edition) formulated by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). The diagnostic criteria for severe and mild pneumonia in children were adopted by the British Thoracic Society (BTS) in 2011",[16],{"name":17,"affiliation":18,"role":19},"Mei Kang, MPH","Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","PRINCIPAL_INVESTIGATOR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","18501709576","mei.kang@shgh.cn",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Xue Tian, Master","02163240090","xue.tian@shgh.cn",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Mei Kang","RECRUITING","Shanghai","Shanghai Municipality","200080","China","CN",{"type":39,"coordinates":40},"Point",[41,42],121.45806,31.22222,{"lat":42,"lon":41},[45,47,50,52,54,56,58],{"name":17,"role":22,"phone":46,"phoneExt":10,"email":24},"+8618501709576",{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Ruilan Wang, PhD","SUB_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Lehao Ren, PhD",{"name":53,"role":49,"phone":10,"phoneExt":10,"email":10},"Dapeng Wang, PhD",{"name":55,"role":19,"phone":10,"phoneExt":10,"email":10},"Shan Gao, Master",{"name":57,"role":49,"phone":10,"phoneExt":10,"email":10},"Jiang Du, PhD",{"name":26,"role":49,"phone":10,"phoneExt":10,"email":10},{"type":19,"investigatorFullName":31,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator",[62,65,67],{"name":63,"class":64},"Wuxi People's Hospital Affiliated to Nanjing Medical University","UNKNOWN",{"name":66,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"name":68,"class":6},"The Central Hospital of Huanggang","100559651","monitoring-of-antimicrobial-resistance-based-on-metagenomics-analyses-in-pneumonia-patients-100559651",false,"NCT06566898","Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients","Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients: a Genomic Epidemiology Study","Inclusion Criteria:\n\n* Patients clinically diagnosed as severe pneumonia and mild pneumonia are diagnosed according to the Guidelines for the diagnosis and Treatment of community-acquired pneumonia in Adults (2019 edition) formulated by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA), who meet 1 of the following major criteria or ≥3 minor criteria can be diagnosed. The diagnostic criteria for severe and mild pneumonia in children were adopted by the British Thoracic Society (BTS) in 2011.\n* Clinical examination was performed, and there was biospecimen (nasopharyngeal swab, oropharyngeal swab, bronchoalveolar lavage fluid, sputum, blood, hydrothorax, lung tissue) remaining in the clinical microbiological examination.\n\nExclusion Criteria:\n\n* Patients whose biological samples may be contaminated;\n* Patients with alveolar lavage fluid or hydrothorax volume less than 200μl.","ALL",{"count":78,"type":79},800,"ESTIMATED","OBSERVATIONAL","Monitoring of antimicrobial resistance (AMR) based on metagenomics analyses in pneumonia patients is critical for optimizing clinical diagnosis and treatment and improving clinical prognosis. This study is designed to ask the following key questions:\n\n1. What is the microbiome maps of patients with severe pneumonia and mild pneumonia ?\n2. How many pathogen resistance genes are carrying in severe pneumonia and mild pneumonia ?\n3. What is the genetic diversity of key pathogens detected in severe pneumonia and mild pneumonia during 2019-2025?",[83,84,85,86],"Pneumonia","Next-generation Sequencing","Microbiome","Antimicrobial Resistance",[83,88,85,86],"Next-generation sequencing","2026-04-21",{"date":91,"type":92},"2026-04-23","ACTUAL",{"date":94,"type":92},"2024-08-01",{"date":96,"type":79},"2026-09-30",{"name":5,"class":6},1]