[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573830":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":10,"responsibleParty":25,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":10,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":10,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":10,"briefSummary":43,"conditions":44,"keywords":10,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"Hainan Medical College","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Nasopharyngeal Carcinoma Patients",null,[12],"Device: IVIM Imaging MRF Imaging",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DEVICE","IVIM Imaging MRF Imaging","IVIM imaging will be performed to evaluate microstructural and perfusion changes in the salivary glands of nasopharyngeal carcinoma patients undergoing radiotherapy. This technique quantifies diffusion and perfusion parameters, providing insights into early tissue damage.\n\nMRF imaging will be used to quantify salivary gland tissue characteristics, including relaxation parameters (T1 and T2 mapping), to monitor radiotherapy-induced damage. The technique enables precise tissue characterization through multi-parametric MRI.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Binjuan Shui","CONTACT","+15256895038","3131683430@qq.com",{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":29,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Shui Bin Juan","Principal Investigator (Graduate Research)","Hainan People's Hospital","100573830","monitoring-salivary-gland-injury-in-nasopharyngeal-carcinoma-patients-after-radiotherapy-using-multi-modal-radiomics-100573830",false,"NCT06751381","Monitoring Salivary Gland Injury in Nasopharyngeal Carcinoma Patients After Radiotherapy Using Multi-Modal Radiomics","A Prospective Study on Monitoring Salivary Gland Injury in Nasopharyngeal Carcinoma Patients After Radiotherapy Using Multi-Modal Radiomics","Inclusion Criteria:\n\n1. Histologically or cytologically confirmed diagnosis of nasopharyngeal carcinoma.\n2. Scheduled to undergo radiotherapy as part of standard treatment.\n3. Aged 18 years or older.\n4. No contraindications to MRI scans (e.g., no implanted metallic devices).\n5. Written informed consent has been provided.\n\nExclusion Criteria:\n\n1. Contraindications to MRI, such as metallic implants or claustrophobia.\n2. Severe comorbid conditions, including significant renal or hepatic dysfunction.\n3. Concurrent participation in another interventional clinical trial.\n4. Pregnant or breastfeeding.\n5. Any condition that may impair compliance with study procedures.","ALL","18 Years",{"count":40,"type":41},45,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the role of intravoxel incoherent motion (IVIM) imaging and magnetic resonance fingerprinting (MRF) techniques in monitoring salivary gland injury in nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. The study will recruit patients diagnosed with NPC who are receiving standard radiotherapy, and quantitative imaging data will be collected using IVIM and MRF techniques at multiple time points, including pre-treatment, during radiotherapy, and post-treatment. The primary objective is to analyze changes in salivary gland structure and function and to identify early imaging biomarkers indicative of radiation-induced injury. The findings are expected to provide new insights into the dynamic progression of salivary gland damage, establish predictive models for the risk of xerostomia, and guide the development of personalized therapeutic strategies to mitigate long-term complications.",[45],"Nasopharyngeal Carcinoma ,Xerostomia,Radiotherapy","NOT_YET_RECRUITING","2025-01-12",{"date":49,"type":50},"2025-01-14","ACTUAL",{"date":52,"type":41},"2025-01-20",{"date":54,"type":41},"2026-12-06",{"name":5,"class":6}]