[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569462":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":22,"responsibleParty":39,"collaborators":41,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"The Cleveland Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with Type 1 Diabetes",null,"Patients with Type 1 Diabetes with or without chronic kidney disease",[13],{"name":14,"affiliation":5,"role":15},"Rong M Zhang, MD","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Andrea Debs","CONTACT","216-445-8354","debsa@ccf.org",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Cleveland Clinic","RECRUITING","Cleveland","Ohio","44195","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-81.69541,41.4995,{"lat":35,"lon":34},[38],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[42,44],{"name":43,"class":6},"Stanford University",{"name":45,"class":46},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100569462","monocytes-in-subjects-with-type-1-diabetes-and-chronic-kidney-disease-100569462",false,"NCT06694558","Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease","Inclusion Criteria:\n\n1. T1D CKD subjects:\n\n   1. Adults, males or females diagnosed with T1D\n   2. Age 18-65 years\n   3. Diagnosed with CKD (eGFR 60-90 ml\u002Fmin\u002F1.73 m2)\n   4. Diagnosed with albuminuria (UACR 30-500 mg\u002Fg)\n   5. On insulin injections or pump\n   6. On CGM\n\n   Based on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR\\\u003C60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR\\>70% A1c 5.0-7.0\n2. Controls: T1D subjects without CKD\n\n   1. Adults, males or females diagnosed with T1D\n   2. Age 18-65 years\n   3. No CKD (eGFR \\>90 ml\u002Fmin\u002F1.73 m2)\n   4. No albuminuria (UACR \\\u003C30 mg\u002Fg)\n   5. On insulin injections or pump\n   6. On CGM\n\nBased on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR\\\u003C60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR\\>70% A1c 5.0-7.0\n\nExclusion Criteria:\n\n1. Hemoglobin \\\u003C9\n2. On GLP-1 agonist or DPP4 inhibitor or sodium-glucose co-transporter-2 inhibitors use within 30 days\n3. pregnancy or plans to become pregnant\n4. On steroids\n5. Diagnosed with cancer, immunosuppression\u002Fautoimmune conditions\n6. Reported heavy alcohol use or recreational drug use\n7. Any condition which jeopardizes patient safety or affects monocytes at physician's discretion","ALL","18 Years","65 Years",{"count":57,"type":58},60,"ESTIMATED","OBSERVATIONAL","This is a cross-sectional study in patients with Type 1 diabetes (TID) and chronic kidney disease (CKD) to test if time in range (TIR) affects the degree of hyperglycemia required for monocyte activation, podocyte injury, and assess if monocyte activation is attenuated by glucagon-like peptide (GLP-1) agonist treatment ex vivo.",[62,63],"Chronic Kidney Disease(CKD)","Type 1 Diabetes (T1D)","2025-06-10",{"date":66,"type":67},"2025-06-11","ACTUAL",{"date":69,"type":67},"2025-03-01",{"date":71,"type":58},"2026-07-01",{"name":5,"class":6},1]