[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100308157":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":26,"locations":31,"responsibleParty":48,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Symptomatic stroke patient",null,"DSA and 3DRA will be performed with access through a 4F sheath at the right femoral artery. Angiograms of intracranial arteries will be obtained by contrast injection at internal carotid artery and vertebral artery ostium from a 4F H1 catheter. Each injection will contain 10ml of iopaminro 300 diluted in 1:1 with normal saline. Each angiographic run will capture a complete series of images from the arterial phase to the end of the venous phase. A 3-dimensional rotational angiogram (a scan time of 4 seconds with 120 images) will be obtained for evaluation of plaque morphology.\n\n2\\. The access site will be closely observed for hemostasis after the procedure. The neurological status and renal function will be monitored.\n\nDiagnosis procedure: DSA\u002F3DRA",[13],"Diagnostic Test: DSA\u002F3DRA",{"label":15,"type":10,"description":11,"interventionNames":16},"Asymptomatic stroke patient",[13],[18],{"type":19,"name":20,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","DSA\u002F3DRA",[15,9],[23],{"name":24,"affiliation":5,"role":25},"Thomas Wai Hong LEUNG, FRCP","PRINCIPAL_INVESTIGATOR",[27],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","852-35053593","drtleung@cuhk.edu.hk",[32],{"facility":5,"status":33,"city":34,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Hong Kong","HK",{"type":37,"coordinates":38},"Point",[39,40],114.17469,22.27832,{"lat":40,"lon":39},[43,44],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},{"name":45,"role":28,"phone":46,"phoneExt":10,"email":47},"Tiffany CHUNG, M.Phil","852-35053856","tiffanyc@cuhk.edu.hk",{"type":25,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Leung Wai Hong Thomas","Professor","100308157","morphology-of-advanced-symptomatic-cerebral-plaques-with-high-embolic-potential-100308157",false,"NCT03291652","Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential","Inclusion Criteria:\n\n* Inclusion Criteria for the Symptomatic Group:\n\n  1. Patient is 30 to 85 years of age, inclusive.\n  2. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD.\n  3. Patient who has no contra-indication for the proposed imaging tests.\n  4. Patient understands the purpose and requirements of the study, and has provided an informed consent.\n* Inclusion Criteria for the Asymptomatic Group:\n\n  1. Patient is 30 to 85 years of age, inclusive.\n  2. Patient who has a high-grade (\\>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence.\n  3. Patient has no MES detected on TCD examination.\n  4. Patient who has no contra-indication for the proposed imaging tests.\n  5. Patient understands the purpose and requirements of the study, and has provided an informed consent.\n\nExclusion Criteria:\n\nSubject who meets one or more of the following criteria cannot be recruited in the study:\n\n1. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc.\n2. A tandem stenosis \\>50% at proximal internal carotid artery.\n3. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \\\u003C100 x 109\u002FL), coagulopathy (INR \\>1.5).\n4. A medical condition that would not allow the patient to adhere to the protocol or complete the study.","ALL","30 Years","85 Years",{"count":61,"type":62},140,"ESTIMATED","OBSERVATIONAL","The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).",[66,67],"Ischemic Stroke","Atheroscleroses, Cerebral",[66,69,70,20],"atherosclerosis","Plaque morphology","2026-02-21",{"date":73,"type":74},"2026-02-24","ACTUAL",{"date":76,"type":74},"2010-02",{"date":78,"type":62},"2027-12-31",{"name":5,"class":6},1]