[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617091":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":32,"responsibleParty":48,"collaborators":50,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":79,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Hôpital le Vinatier","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Farming game",null,"motivational fluctuation task: participants can gain points by engaging in some activities in the environment or just staying in one place. Throughout the experiment the level of reward for each patch will change to measure participants' sensitivity to different reward levels.",{"label":13,"type":10,"description":14,"interventionNames":10},"Fastest Queue","prospective planning and learning task: participants observe two queues moving at different speeds shown to them in the middle of the screen. They need to decide which of two queues to stand in, and are asked about their beliefs about how fast individual queue members might get to the goal.",{"label":16,"type":10,"description":17,"interventionNames":10},"Treasure hunt","sequential and incremental goal pursuit task: Participants need to decide between multiple goals to pursue framed as treasures in order to gain points. The treasures can be worth different amounts and the participant will be travelling to them at different speeds.",[19],{"name":20,"affiliation":21,"role":22},"Nils Kolling, PhD","INSERM U1208, Ecological Cognition and Computation Team","PRINCIPAL_INVESTIGATOR",[24,28],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+33 04 72 91 34 95","nils.kolling@inserm.fr",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Méline Devaluez, PhD","+33437915514","meline.devaluez@ch-le-vinatier.fr",[33],{"facility":34,"status":10,"city":35,"state":10,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"INSERM","Bron","69500","France","FR",{"type":40,"coordinates":41},"Point",[42,43],4.91303,45.73865,{"lat":43,"lon":42},[46],{"name":20,"role":25,"phone":26,"phoneExt":47,"email":27},"+33",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[51],{"name":52,"class":53},"INSERM U1208","UNKNOWN","100617091","motivation-learning-and-decision-making-in-changing-environments-100617091",false,"NCT07314112","Motivation, Learning and Decision Making in Changing Environments","MOTILEARN","Inclusion Criteria:\n\n* Age between 18 and 45\n* Fluent in French (reading and speaking)\n* Membership or entitlement to a social security plan\n* Have given written, informed consent to take part in the study\n* Normal or corrected-to-normal vision\n* Right-handed\n* Body mass index (BMI) between 18.5 and 30\n\nNon-inclusion Criteria:\n\n* contraindication to MRI: pacemaker, heart battery, cardiac defibrillator, certain heart valves or neurosurgical clips, cochlear implant, implanted automated injection systems (insulin pump), intraocular metal projectiles, people who work or have worked with metals (excluding X-rays prior to MRI).\n* under guardianship or curatorship or deprived of their liberty\n* Participating in a clinical trial or in a period of exclusion from a previous clinical trial\n* Breast-feeding or pregnant women\n* claustrophobia\n* Neurological disorder or severe chronic illness (diabetes, heart, kidney, lung or liver disease, inflammatory disease, psychiatric illness, etc.).\n* The participant does not wish to be informed of any abnormalities detected during the MRI examination.",true,"ALL","18 Years","45 Years",{"count":66,"type":67},120,"ESTIMATED","OBSERVATIONAL","The main objective of this study is to develop a models of sequential decision-making, learning and motivation that includes emotions as driving forces of adaptive behaviour. Using functional magnetic resonance imaging (fMRI), the investigators will test the hypotheses that distinct parts of the prefrontal cortex play specific roles in naturalistic decision-making.\n\nThe main hypothesis is that distinct regions of the prefrontal cortex will be differentially involved in learning, motivation, and decision-making in naturalistic tasks. More specifically, the investigators hypothesise that by using a novel set of tasks they have designed in combination with fMRI, they can construct a neurocognitive model that explains how humans make adaptive decisions in dynamic and temporally extended reward environments.\n\nA key region that the investigators believe will play a role in representing the internal and external parameters necessary for adaptive behaviours in the tasks is the anterior cingulate cortex. Depending on the task requirements, this region will further interact with other distinct prefrontal regions such as the frontal pole or dorsolateral prefrontal cortex.\n\nSecondary hypotheses will also be investigated, specific to each specific task.\n\nAll data will be collected during a single visit lasting approximately 3.5 hours for each participant. Participants will perform a cognitive task inside the MRI scanner. Each participant will perform only one of the three possible cognitive conditions\u002Ftasks (Treasure Hunt, Fastest Queue, or Farm Game).\n\nEach task is presented in the form of a video game played on a computer. Participants play a character who makes repeated choices. Participants are asked to try to collect as many points as possible within a limited time frame (Farm Game) or with limited trials (Fastest Queue and Treasure Hunt).",[71,72],"Neurocognitive Model","Decision-Making",[74,75,76,77,78],"Cognitive neurosciences","decision making","reward","cognitive psychology","fMRI","NOT_YET_RECRUITING","2026-01-05",{"date":82,"type":83},"2026-01-07","ACTUAL",{"date":85,"type":67},"2026-01",{"date":87,"type":67},"2029-01",{"name":5,"class":6},1]