[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540069":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":60,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":21,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":18,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Balance training intervention group","EXPERIMENTAL","The program HiBalance-MS is based on scientifically well-established principles of exercise training and postural control. It will be conducted as a progressive individually adjusted group training to challenge the specific balance deficit of every participant. To ensure highly challenging exercises, each task is individually adjusted, e.g., by altering the base of support, increasing speed, restricting vision and varying grade of multitasking. Daily variation in capacity will be rated before each training session and participants will at the end of each session rate the challenging level. The training will be performed in the clinic, at Karolinska University Hospital, for an hour, twice a week for 10 weeks, as a group intervention including 6 to 8 participants and facilitated by two physiotherapists\u002Ftrainers.",[13],"Other: HiBalance-MS",{"label":15,"type":16,"description":17,"interventionNames":18},"No intervention control group","NO_INTERVENTION","Participants in the control group are encouraged to maintain their normal physical activities and are not restricted from participation in ongoing rehabilitation programs.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"HiBalance-MS","See arm description for intervention group.",[9],[25],{"name":26,"affiliation":27,"role":28},"Sverker Johansson, Ph.D","Karolinska Institutet, org.nr 202100-2973","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Compliance Office Karolinska Institutet","CONTACT","+46852480000","compliance@ki.se",{"name":36,"role":32,"phone":33,"phoneExt":18,"email":37},"Erika Franzén, Ph.D","erika.franzen@ki.se",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Stockholm","Stockholm County","17177","Sweden","SE",{"type":47,"coordinates":48},"Point",[49,50],18.06871,59.32938,{"lat":50,"lon":49},[53,56],{"name":26,"role":32,"phone":54,"phoneExt":18,"email":55},"+46702861260","sverker.johansson@ki.se",{"name":57,"role":32,"phone":58,"phoneExt":18,"email":59},"Andreas Wallin, Ph.D","+46735137604","andreas.wallin@ki.se",{"type":28,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Sverker Johansson","Associate professor",[64],{"name":65,"class":6},"Karolinska University Hospital","100540069","motor-cognitive-performance-in-people-with-multiple-sclerosis-100540069",false,"NCT06312046","Motor-cognitive Performance in People With Multiple Sclerosis","Motor-cognitive Performance in People With Multiple Sclerosis - Brain Activity and Effects of Balance Exercise","Inclusion Criteria:\n\n* an MS diagnosis according to McDonald criteria;\n* an overall MS-disability score from 2.0 to 5.5 according to the Expanded Disability Status Scale;\n* ability to walk 100 m without aid;\n* a maximum score of 24 in the Mini-BESTest (i.e., \\\u003C 25 points)\n* 18 to 65 years of age\n\nExclusion Criteria:\n\n* cognitive impairment as indicated by a score \\\u003C21 in the Montreal Cognitive Assessment;\n* presence of other conditions that would substantially influence balance;\n* an MS relapse or change of disease-modifying treatment within the past 8 weeks","ALL","18 Years","65 Years",{"count":77,"type":78},90,"ESTIMATED","INTERVENTIONAL",[81],"NA","Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities for an independent lifestyle.\n\nThe investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to determine the effects of the program. The hypothesis is that progressively challenging balance exercise programs that are specific to the balance control domains affected by MS will be effective to improve balance control, walking, motor-cognitive performance, activity performance and health related quality of life.",[84,85],"Multiple Sclerosis","Postural Balance",[87,88,89],"Balance","Exercise","Multiple sclerosis","2025-07-07",{"date":92,"type":93},"2025-07-10","ACTUAL",{"date":95,"type":93},"2024-02-26",{"date":97,"type":78},"2027-08-31",{"name":5,"class":6},1]