[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612198":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":41,"locations":50,"responsibleParty":71,"collaborators":26,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":26,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":26,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":99,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Istanbul Gelisim University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Migraine Patients","EXPERIMENTAL","Adult participants aged 18-45 with a prior diagnosis of migraine according to IHS criteria.\n\nTranscranial Magnetic Stimulation (TMS)\n\nSurface Electromyography (sEMG)\n\nNeedle EMG \u002F Single Motor Unit (SMU) Recording",[13,14,15],"Other: Transcranial Magnetic Stimulation (TMS)","Device: Surface Electromyography (sEMG)","Other: Needle EMG \u002F Single Motor Unit (SMU) Recording",{"label":17,"type":18,"description":19,"interventionNames":20},"Healthy Controls","SHAM_COMPARATOR","Age- and sex-matched adults without a history of migraine or neurological disorders.\n\nThey undergo the same sEMG and needle EMG\u002FSMU procedures as the migraine group, but the TMS is sham.\n\nSurface Electromyography (sEMG)\n\nNeedle EMG \u002F Single Motor Unit (SMU) Recording\n\nTranscranial Magnetic Stimulation (TMS) SHAM",[14,15],[22,27,32],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"Transcranial Magnetic Stimulation (TMS)","Non-invasive brain stimulation applied to the primary motor cortex to elicit motor evoked potentials (MEP) and cortical silent periods (CSP).\n\n70 mm figure-of-eight coil used with Magstim 200² Monophasic Stimulator.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DEVICE","Surface Electromyography (sEMG)","Bipolar Ag\u002FAgCl electrodes placed over the first dorsal interosseous (FDI) muscle to record muscle responses to TMS.",[17,9],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"Needle EMG \u002F Single Motor Unit (SMU) Recording","Sterile Teflon-coated needle electrodes inserted into the FDI muscle to record activity of individual motor units during TMS and voluntary contractions.",[17,9],[37],{"name":38,"affiliation":39,"role":40},"Kemal Sıtkı Türker, Prof. Dr.","Istanbul Gelisim University, Faculty of Dentistry, Translational Dentistry Research Laboratory","PRINCIPAL_INVESTIGATOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":26,"email":46},"Murat Kara, MSc","CONTACT","+905314708141","murkara@gelisim.edu.tr",{"name":38,"role":44,"phone":48,"phoneExt":26,"email":49},"+905325987791","ksturker@gelisim.edu.tr",[51],{"facility":39,"status":26,"city":52,"state":52,"zip":53,"country":54,"countryCode":26,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Istanbul","34310","Turkey (Türkiye)",{"type":56,"coordinates":57},"Point",[58,59],28.94966,41.01384,{"lat":59,"lon":58},[62,63,64,65,67,69],{"name":43,"role":44,"phone":45,"phoneExt":26,"email":46},{"name":38,"role":44,"phone":48,"phoneExt":26,"email":49},{"name":38,"role":40,"phone":26,"phoneExt":26,"email":26},{"name":43,"role":66,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"name":68,"role":66,"phone":26,"phoneExt":26,"email":26},"Muhammed Yurtseven, MSc",{"name":70,"role":66,"phone":26,"phoneExt":26,"email":26},"Nilgün Yıldız, MSc",{"type":72,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100612198","motor-evoked-potential-and-cortical-silent-period-in-migraine-100612198",false,"NCT07250464","Motor Evoked Potential and Cortical Silent Period in Migraine","Investigation of Motor Evoked Potential and Cortical Silent Period in Migraine Patients","Inclusion Criteria:\n\n* Age 18-45 years.\n* Right-handed individuals.\n* Migraine patients: diagnosed according to International Headache Society (IHS) criteria.\n* Healthy controls: no history of migraine or other neurological disorders.\n* Able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* History of epilepsy or other seizure disorders.\n* Presence of metal implants, pacemakers, or other contraindications to TMS.\n* Pregnancy or breastfeeding.\n* History of significant neurological or psychiatric disorders.\n* Use of medications that significantly alter cortical excitability (e.g., antiepileptics, benzodiazepines) in the last 2 weeks.\n* Any musculoskeletal condition preventing safe participation in EMG\u002FTMS procedures.",true,"ALL","18 Years","45 Years",{"count":85,"type":86},20,"ESTIMATED","INTERVENTIONAL",[89],"NA","The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods. To this end, Motor Evoked Potential (MEP) and Cortical Silence Period (CSP) parameters obtained using Transcranial Magnetic Stimulation (TMS) will be measured and comparisons will be made between migraine patients and healthy controls. Since CSP duration is used specifically in the evaluation of GABA-B-mediated inhibitory mechanisms, it has the potential to directly measure the effect of migraine on cortical inhibition.",[92,93],"Migraine","Healty Controls",[95,96,97,98],"cortical silent period","migraine","single motor unit","transcranial magnetic stimulation","NOT_YET_RECRUITING","2025-11-26",{"date":102,"type":103},"2025-11-28","ACTUAL",{"date":105,"type":86},"2025-12-01",{"date":107,"type":86},"2026-02-01",{"name":5,"class":6},1]