[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546839":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":42,"responsibleParty":74,"collaborators":76,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":25,"eligibilityCriteria":84,"healthyVolunteers":81,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Biomechanical Response to Balance Challenging Environments","EXPERIMENTAL","Aim 1 will determine how people with chronic stroke (PwCS) adapt their gait in response to different balance challenging environments. For Aim 1, the investigators will conduct a single-session cross sectional study to assess gait patterns during and immediately following walking practiced in balance challenging environments. PwCS will perform treadmill walking in a natural unmodified environment, and in two balance-challenging environments that will include a Movement Amplification Environment (MAE), and an unpredictable lateral perturbation environment. All enrolled participants will undergo clinical outcome measure assessments to identify baseline function. In addition, all participants in Aim 1 will undergo biomechanical testing while walking in each of the three environments to assess changes in their walking patterns.",[13],"Behavioral: Treadmill walking in varying external environments",{"label":15,"type":10,"description":16,"interventionNames":17},"Heart Rate Response to Balance Challenging Environments","Aim 2 is a feasibility study to determine if high intensity gait training can be achieved within a MAE. For Aim 2, the investigators will employ a two-way cross over study design consisting of two gait training sessions (one in a natural unmodified environment and the other in a MAE). The investigators will examine cardiovascular response, perceived exertion, and gait characteristics (speed, number of steps) to quantify if the MAE impacts training intensity. All enrolled participants will undergo clinical outcome measure assessments. In addition, all participants for Aim 2, heart rate (HR), rate of perceived exertion (RPE), number of steps taken during the training sessions, and walking speeds will be recorded.",[18],"Behavioral: High intensity gait training in varying external environments",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","High intensity gait training in varying external environments","Participants will engage in two 45-minutes treadmill-based gait training sessions. These training sessions will occur on separate days. One session will be performed in a natural unmodified environment. One session will be performed in a movement amplification environment. The goal of each session will be to achieve 40-minutes of walking within a target heart rate range of 70-85% of estimated heart rate max. Each session will begin and end with a 2.5 minute warm-up and cool down respectively. Participants will be given rest breaks as needed.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Treadmill walking in varying external environments","Participants will perform a series of treadmill walking trials. Each trial will consist of 400 total steps. The first 100 steps will be performed in a natural unmodified environment. The next 200 steps will be performed in 1 of 3 external environments (natural unmodified, movement amplification, or unpredictable lateral perturbations). The final 100 steps will be performed in a natural unmodified environment. Participants will be given rest breaks between trials.",[9],[31],{"name":32,"affiliation":33,"role":34},"Keith Edward Gordon, PhD","Edward Hines Jr. VA Hospital, Hines, IL","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Keith E Gordon, PhD","CONTACT","(708) 202-8387","28387","Keith.Gordon2@va.gov",[43,62],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Northwestern University","NOT_YET_RECRUITING","Chicago","Illinois","60201","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-87.65005,41.85003,{"lat":55,"lon":54},[58],{"name":59,"role":38,"phone":60,"phoneExt":25,"email":61},"Keith Gordon, PhD","312-503-3339","keith-gordon@northwestern.edu",{"facility":33,"status":63,"city":64,"state":47,"zip":65,"country":49,"countryCode":50,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"RECRUITING","Hines","60141-3030",{"type":52,"coordinates":67},[68,69],-87.8395,41.85364,{"lat":69,"lon":68},[72,73],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"type":75,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[77],{"name":44,"class":78},"OTHER","100546839","movement-amplification-gait-training-to-enhance-walking-balance-post-stroke-100546839",false,"NCT06400186","Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke","Inclusion Criteria:\n\n* History of chronic stroke (more than 6 months post-stroke) with weakness on one side\n* Ability to ambulate over ground for 10 meters with or without a single cane, and\u002For ankle-foot orthosis\n* Ability to tolerate 10 minutes of standing\n\nExclusion Criteria:\n\n* Presence of cognitive impairment (score of 22\u002F30 on the Montreal Cognitive Assessment scale (MoCA))\n* Presence of aphasia (score of 71\u002F100 on the Mississippi Aphasia Screening Test (MAST))\n* Excessive spasticity in lower limbs (score of \\> 3 on the Modified Ashworth Scale\n* Severe cardiovascular and pulmonary disease affecting gait and balance\n* History of recurrent fractures or known orthopedic problems in the lower extremities (i.e. heterotopic ossification) affecting gait and balance\n* Concomitant central or peripheral neurological injury (i.e. traumatic head injury or peripheral nerve damage in lower limbs) affecting gait and balance\n* Evidence of cerebellar ataxia\n* Presence of unhealed decubiti or other skin compromise\n* Enrollment in concurrent physical therapy or research involving gait or balance training\n* Use of braces\u002Forthotics crossing the knee joint\n* Known pregnancy","ALL","18 Years","80 Years",{"count":89,"type":90},30,"ESTIMATED","INTERVENTIONAL",[93],"NA","Stroke is a leading cause of disability in the United States, affecting approximately 795,000 people annually. The Veteran's Health Administration provides over 60,000 outpatient visits for stroke-related care annually at a cost of over $250 million. Among ambulatory people with chronic stroke (PwCS), impaired balance is a common health concern that substantially limits mobility (those with the worst balance walk the least). This project will explore adaptive strategies employed by PwCS in balance challenging environments and if a novel gait training intervention using a robotic device to amplify a person's self-generated movements can improve walking balance. The development of effective interventions to increase walking balance among PwCS will positively impact Veterans' health, quality of life, and ability to participate in walking activities.",[96],"Chronic Hemiparetic Stroke",[98,99,100,101,102,103],"gait","balance","walking","locomotion","stroke","rehabilitation robotics","2026-06-18",{"date":106,"type":107},"2026-06-23","ACTUAL",{"date":109,"type":107},"2024-08-15",{"date":111,"type":90},"2026-07-31",{"name":5,"class":6},2]