[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616754":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":44,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":67,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"CASSISS-MPR",null,[12],"Drug: Standardized medical therapy targeting vascular risk factors and stroke prevention",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DRUG","Standardized medical therapy targeting vascular risk factors and stroke prevention","Dual antiplatelet treatment and management of vascular risk factors, in accordance with AHA\u002FASA guidelines",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jichang Luo, M.D.","CONTACT","+86 13120136577","luojichang_dr@sina.com",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Department of Neurosurgery, Xuanwu hospital","RECRUITING","Beijing","Xicheng District","100053","China","CN",{"type":35,"coordinates":36},"Point",[37,38],116.39723,39.9075,{"lat":38,"lon":37},[41],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45,48,50,52],{"name":46,"class":47},"Xuanwu Hebei Hospital","UNKNOWN",{"name":49,"class":47},"Xuanwu Xiongan Hospital",{"name":51,"class":47},"Xuanwu Chifeng Hospital",{"name":53,"class":47},"Xuanwu Jinan Hospital","100616754","mpr-for-stroke-risk-assessment-of-icas-100616754",false,"NCT07309718","MPR for Stroke Risk Assessment of ICAS","MRI-Derived Pressure Ratio: a Novel Noninvasive Hemodynamic Biomarker for Stroke Risk Stratification in Intracranial Atherosclerotic Stenosis","Inclusion Criteria:\n\n1. Adults aged 18 to 80 years.\n2. Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation.\n3. Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA.\n4. Written informed consent obtained from the participant or a legal representative.\n\nExclusion Criteria:\n\n1. Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital\u002Fgenetic abnormalities.\n2. More than 50% stenosis of the extracranial carotid artery on the ipsilateral side.\n3. Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3.\n4. Contraindications to antiplatelet therapy or statins.\n5. Inability to undergo MRI due to metal implants or claustrophobia.","ALL","18 Years","80 Years",{"count":65,"type":66},400,"ESTIMATED","12 Months","OBSERVATIONAL","Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.",[71,72,73],"ICAS - Intracranial Atherosclerosis","Stroke Ischemic","Hemodynamic",[71,72,73,75],"Pressure ratio","2025-12-15",{"date":78,"type":79},"2025-12-30","ACTUAL",{"date":81,"type":79},"2025-12-01",{"date":83,"type":66},"2028-03-31",{"name":5,"class":6},1]