[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631169":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":21,"centralContacts":22,"locations":21,"responsibleParty":33,"collaborators":21,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":21,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":21,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":61,"whyStopped":21,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":21},{"fullName":5,"class":6},"The Hospital for Sick Children","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"MRgFUS Treatment","MRgFUS treatment of epileptogenic brain lesions",[12],"Procedure: Ablation",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","Ablation","MRI-guided focused ultrasound ablation (MRgFUS) of central brain lesions in children with drug-resistant epilepsy.",[9],[20],"ExAblate Neuro",null,[23,28],{"name":24,"role":25,"phone":26,"phoneExt":21,"email":27},"George M Ibrahim, MD, PhD","CONTACT","416-813-6125","george.ibrahim@sickkids.ca",{"name":29,"role":25,"phone":30,"phoneExt":31,"email":32},"Adam C Waspe, PhD","416-813-7500","304652","adam.waspe@sickkids.ca",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","George Ibrahim","Dr. George M. Ibrahim, MD, PhD","100631169","mrgfus-for-childhood-epilepsy-100631169",false,"NCT07497178","MRgFUS for Childhood Epilepsy","A Prospective Cohort Study of High Intensity Focused Ultrasound Ablation for Brain Lesions in Children With Drug Resistant Epilepsy","Inclusion Criteria:\n\n• Age 4 - 17 years at time of enrollment • A confirmed diagnosis of epileptogenic lesion refractory to medication therapy. • Diagnosis of intractable epilepsy with failure after trial of two anti-epileptic medications. • Able to fit into a standard MRI unit. • Subjects with benign (WHO grade I) centrally located intracranial tumors which require clinical intervention and are known to carry minimal hemorrhage risk. • Patients with a head circumference \\>52cm and can tolerate frame-based stereotaxy. • Subjects should be on a stable dose of all condition-related medications for 30 days prior to study entry as determine by medical records. • The epileptogenic lesions (HH or other) can be targeted by the Exablate device. The lesion and region of treatment must be apparent on MRI and CT such that image fusion can delineate and model targeting when registered to the Exablate device.\n\nExclusion Criteria:\n\n• Any contraindication to MRI scanning • Pregnancy • Evidence of ethanol or substance abuse • Significant cardiac, respiratory, renal, or endocrine conditions (including arrhythmias) that increase procedural risk • History of abnormal bleeding disorders or hemorrhage • Use of anticoagulant, antiplatelet, or hemorrhage-associated medications","ALL","4 Years","17 Years",{"count":48,"type":49},20,"ESTIMATED","INTERVENTIONAL",[52],"NA","The goal of this observational study is to learn if magnetic resonance imaging guided focused ultrasound (MRgFUS) can treat brain lesions causing epilepsy in children with drug resistant epilepsy. The main questions it aims to answer are:\n\nIs MRgFUS safe in children with drug-resistant epilepsy due to central brain lesions?\n\nDoes MRgFUS treatment reduce seizure frequency and severity and improve quality-of-life?\n\nResearchers will prospective assess outcomes following MRgFUS in children.\n\nParticipants undergoing MRgFUS will complete seizure diaries and questionnaires related to seizure severity and quality-of-life.",[55,56],"Drug Resistant Epilepsy","Epilepsy",[56,58,59,60],"DRE","MRI-guided focused ultrasound","MRgFUS","NOT_YET_RECRUITING","2026-03-23",{"date":64,"type":65},"2026-03-27","ACTUAL",{"date":67,"type":49},"2026-03-01",{"date":69,"type":49},"2029-12-31",{"name":5,"class":6}]