[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642913":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":30,"centralContacts":38,"locations":29,"responsibleParty":46,"collaborators":29,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":29,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":29,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":75,"whyStopped":29,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":29},{"fullName":5,"class":6},"Central South University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Precision cTBS stimulation group","EXPERIMENTAL","Undergo precise targeted accelerated cTBS guided by individual right IPS-right BLA functional connectivity. The individual IPS target is located using the Visor2 neuronavigation system, with treatment administered continuously for 5 days, 5 times per day, each session lasting 120 seconds with 1800 pulses, and an interval of 50 minutes between sessions.",[13],"Device: continuous theta burst stimulation(cTBS)",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-precise cTBS stimulation group","Receive non-individualised target cTBS. Use the cortical target corresponding to the P4 site of the international 10-20 EEG system as the stimulation target, with the remaining equipment, stimulation intensity, frequency, treatment course, number of pulses per session, and treatment procedures consistent with the precise cTBS group.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham stimulation group","SHAM_COMPARATOR","Receive sham cTBS. Apart from using a sham coil with no effective magnetic field output, the coil placement, neuronavigation procedure, number of treatments, treatment duration, and follow-up process are consistent with the precise cTBS group.",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DEVICE","continuous theta burst stimulation(cTBS)","Accelerated cTBS treatment was administered over 5 days, five times daily (1800 pulses per session, a total of 9000 pulses per day, with 50-minute intervals between sessions), at a stimulation intensity of 80%-120% of the resting motor threshold. The precise stimulation group targeted locations based on individual baseline functional MRI data, calculating the coordinates of strongest functional connectivity between the right IPS and the right basolateral amygdala (BLA), and implemented via neuronavigation system registration; the non-precise stimulation group targeted the cortical projection coordinates of the P4 electrode site according to the international 10-20 EEG system; the sham stimulation group used the same parameters but with a sham coil.",[15,9,19],null,[31,35],{"name":32,"affiliation":33,"role":34},"Yan Zhang, PhD","Second Xiangya Hospital of Central South University","STUDY_CHAIR",{"name":36,"affiliation":33,"role":37},"Yumeng Ju, PhD","PRINCIPAL_INVESTIGATOR",[39,43],{"name":36,"role":40,"phone":41,"phoneExt":29,"email":42},"CONTACT","86+18100731091","yumeng.ju@csu.edu.cn",{"name":44,"role":40,"phone":29,"phoneExt":29,"email":45},"Jing Yang","yangjing2025@126.com",{"type":37,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Yumeng Ju","Associate Investigator","100642913","mri-guided-accelerated-ctbs-for-generalized-anxiety-disorder-100642913",false,"NCT07640945","MRI-Guided Accelerated cTBS for Generalized Anxiety Disorder","Efficacy and Neural Mechanisms of MRI-Guided Accelerated Continuous Theta Burst Stimulation Targeting the Inferior Parietal Lobule in Generalized Anxiety Disorder: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Outpatients or inpatients at the Second Xiangya Hospital who are confirmed by two experienced psychiatrists to meet the International Classification of Diseases 11th Revision (ICD-11) diagnostic criteria for generalized anxiety disorder.\n* Aged 18 to 65 years, regardless of gender.\n* Right-handed.\n* Junior high school education or above, with the ability to provide informed consent and complete cognitive assessments.\n* Able to receive anti-anxiety treatment during the follow-up period according to the instructions of outpatient or inpatient physicians.\n* Hamilton Anxiety Rating Scale (HAMA) score ≥14 and Patient Health Questionnaire-15 (PHQ-15) score ≥5.\n\nExclusion Criteria:\n\n* Presence of psychotic symptoms.\n* Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, current psychiatric symptoms, or post-traumatic stress disorder based on SCID-5 assessment, either currently or within the past year.\n* Organic brain disease or severe somatic diseases, such as thyroid disease, lupus, diabetes, lung disease, liver disease, kidney disease, infection, or major trauma.\n* Intracranial implants.\n* Clinically significant sensory impairments that cannot be corrected, such as color blindness or hearing impairment.\n* Pregnant or breastfeeding women.\n* Positive urine drug screen.\n* Abnormal thyroid function tests.\n* Personal history of epilepsy or family history of epilepsy.\n* Receipt of physical therapy within the past six months, such as repetitive transcranial magnetic stimulation or electroconvulsive therapy.\n* Suspected or confirmed history of alcohol or drug dependence.\n* Use of anticoagulants, such as heparin or warfarin, corticosteroids, or thyroid disease treatments within the past three months.\n* Current use of psychoactive medications.\n* Receipt of neurocognitive assessments similar to those used in this study within the past 12 months.","ALL","18 Years","65 Years",{"count":60,"type":61},75,"ESTIMATED","INTERVENTIONAL",[64],"NA","Generalized Anxiety Disorder (GAD) is a common psychiatric disorder associated with persistent anxiety, functional impairment, and incomplete response to existing treatments. Although transcranial magnetic stimulation (TMS) has shown therapeutic potential in anxiety disorders, conventional treatment schedules often require several weeks and may not provide sufficiently rapid symptom relief. This study aims to evaluate the efficacy and safety of precision-targeted accelerated continuous theta-burst stimulation (cTBS) guided by individualized functional connectivity between the intraparietal sulcus (IPS) and the amygdala in patients with GAD.",[67],"Generalized Anxiety Disorder (GAD)",[67,69,70,71,72,73,74],"transcranial magnetic stimulation","Single-center","Randomized Controlled Trial","Non-invasive brain stimulation","Neuromodulation","theta burst stimulation","NOT_YET_RECRUITING","2026-06-09",{"date":78,"type":79},"2026-06-11","ACTUAL",{"date":81,"type":61},"2026-06",{"date":83,"type":61},"2027-02",{"name":5,"class":6}]