[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477718":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":47,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":7,"enrollmentInfo":63,"targetDuration":7,"studyType":66,"phases":7,"briefSummary":67,"conditions":68,"keywords":7,"overallStatus":41,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Sydney","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Caterina Brighi","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Shona Silvester","CONTACT","+61286271185","shona.silvester@sydney.edu.au",{"name":19,"role":15,"phone":7,"phoneExt":7,"email":20},"David Waddington","david.waddington@sydney.edu.au",[22,39],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"North Shore Private Hospital","NOT_YET_RECRUITING","St Leonards","New South Wales","2065","Australia","AU",{"type":31,"coordinates":32},"Point",[33,34],151.19836,-33.82344,{"lat":34,"lon":33},[37],{"name":14,"role":15,"phone":38,"phoneExt":7,"email":17},"+61 2 8627 1185",{"facility":40,"status":41,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":42,"geoPoint":44,"contacts":45},"Royal North Shore Hospital","RECRUITING",{"type":31,"coordinates":43},[33,34],{"lat":34,"lon":33},[46],{"name":14,"role":15,"phone":38,"phoneExt":7,"email":17},{"type":48,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[50],{"name":51,"class":52},"The Brain Cancer Group","UNKNOWN","100477718","mri-hypoxia-study-for-glioblastoma-multiforme-gbm-radiation-therapy-100477718",false,"NCT05500612","MRI Hypoxia Study for Glioblastoma Multiforme (GBM) Radiation Therapy","Magnetic Resonance Imaging of Hypoxia for Radiation Treatment Guidance in Glioblastoma Multiforme (MANGO)","MANGO","Inclusion Criteria:\n\n* Suspected high-grade glioma (HGG) \u002F glioblastoma multiforme (WHO grade IV) at initial radiological examination\n* Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2\n* Available for scanning on two separate days\n\nExclusion Criteria:\n\n* Women lactating, pregnant or of childbearing potential who are not willing to avoid pregnancy during the study\n* Patients with a history of severe renal disease(s) (eGFR \\\u003C20) that cannot tolerate gadolinium chelate contrast agents.\n* Geographically remote patients unable to agree to imaging schedule\n* Patients who have received anti - vascular endothelial growth factor (anti-VEGF) monoclonal antibody therapy the 3 months prior to recruitment\n* Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.\n* Patients with significant cardiac or pulmonary disease including cardiac arrythmias or Chronic Obstructive Pulmonary Disease (COPD) that are unable to tolerate high flow O2 for oxygen contrast.\n* Patients taking carbonic anhydrase inhibitors (Acetazolamide)\n* History of glaucoma\n* Any implant, foreign body, 3 Tesla (3T) MRI incompatible device, or other contraindication to MRI imaging.","ALL","18 Years",{"count":64,"type":65},20,"ESTIMATED","OBSERVATIONAL","This study is designed to evaluate the role of Oxygen Enhanced (OE) Magnetic resonance imaging (MRI) and Blood Oxygenation Level Dependent (BOLD) MRI in detecting regions of hypoxic tumour and to evaluate their use as imaging methods to selectively deliver targeted radiotherapy to regions of aggressive disease.",[69],"Glioblastoma Multiforme","2026-05-15",{"date":72,"type":73},"2026-05-19","ACTUAL",{"date":75,"type":73},"2024-08-14",{"date":77,"type":65},"2026-12",{"name":5,"class":6},2]