[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100459223":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":22,"locations":32,"responsibleParty":50,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":11,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":11,"enrollmentInfo":64,"targetDuration":11,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":35,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Erlangen-Nürnberg Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with food hypersensitivity","EXPERIMENTAL",null,[13],"Other: biopsy sampling",{"label":15,"type":10,"description":11,"interventionNames":16},"healthy controls",[13],[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"biopsy sampling","1. Biopsies are homogenised in buffer and used for the determination of mucosal IgE and inflammatory parameters.\n2. Biopsies are used to isolate organoids, stimulate them with blood cells and food antigens and to study gene and protein expression.",[15,9],[23,28],{"name":24,"role":25,"phone":26,"phoneExt":11,"email":27},"Yurdagül Zopf, Prof","CONTACT","+4991318545218","yurdaguel.zopf@uk-erlangen.de",{"name":29,"role":25,"phone":30,"phoneExt":11,"email":31},"Walburga Dieterich, Dr","+4991318535128","walburga.dieterich@uk-erlangen.de",[33],{"facility":34,"status":35,"city":36,"state":11,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg","RECRUITING","Erlangen","91052","Germany","DE",{"type":41,"coordinates":42},"Point",[43,44],11.00783,49.59099,{"lat":44,"lon":43},[47],{"name":48,"role":25,"phone":49,"phoneExt":11,"email":27},"Yurdaguel Zopf, Prof","49 9131 8545218",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","yurdagül zopf","Professor Dr.","100459223","mucosal-ige-to-improve-diagnosis-of-food-allergy-and-food-hypersensitivity-100459223",false,"NCT05259826","Mucosal IgE to Improve Diagnosis of Food Allergy and Food Hypersensitivity","Improving the Diagnosis of Food Allergy and Food Intolerance by Determining Mucosal IgE and Inflammatory Markers and Validating With Intestinal in Vitro Organoids","Inclusion Criteria:\n\n* informed consent\n* patients with suspected food allergy or hypersensitivity\n* healthy controls with indications for endoscopic diagnostics, e.g. tumour history within the family, exclusion of gastritis\n\nExclusion Criteria:\n\n* pregnant person",true,"ALL","18 Years",{"count":65,"type":66},115,"ESTIMATED","INTERVENTIONAL",[69],"NA","Aim of the study is to improve the diagnosis of food allergy and hypersensitivity. Intestinal homogenates will be used to determine total IgE, specific IgE, tryptase, histamine and inflammation parameters (IFNgamma, TNFalpha). These data will be correlated with serum values and disease status. In addition, organoids from duodenal tissue will be isolated and cultured in vitro and stimulated with the major food allergens. The gene and protein expression will be checked to identify relevant biomarkers.",[72,73],"Food Allergy","Food Hypersensitivity",[75,76],"mucosal IgE","inflammation parameter","2024-07-03",{"date":79,"type":80},"2024-07-05","ACTUAL",{"date":82,"type":80},"2022-02-01",{"date":84,"type":66},"2025-01-31",{"name":5,"class":6},1]