[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544199":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":18,"collaborators":10,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":10,"eligibilityCriteria":28,"healthyVolunteers":29,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":10,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":10},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Bilateral SSNHL",null,"150 participants will be enrolled with SSNHL involving bilateral ears.",{"label":13,"type":10,"description":14,"interventionNames":10},"Unilateral SSNHL","150 participants will be enrolled with SSNHL involving unilateral ear.",{"label":16,"type":10,"description":17,"interventionNames":10},"Healthy Controls","100 age-matched healthy controls will be enrolled.",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dan Bing","associate professor","100544199","multi-omics-characteristics-and-prognosis-of-idiopathic-sudden-sensorineural-hearing-loss-100544199",false,"NCT06365775","Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss","Multi-omics Characteristics and Prognosis in Patients With Idiopathic Sudden Sensorineural Hearing Loss","Inclusion Criteria:\n\n* Age ≥ 4\n* Participants with SSNHL: unilateral or bilateral sensorineural hearing loss of \\> 30 dB HL (decibel) involving at least 3 continuous test frequencies developing within 72 hours\n* Healthy controls: people with PTA thresholds of all test frequencies ≤ 20 dB HL and without otologic disease in the last 3 months\n* Completed informed consent and promised to finish follow-ups\n\nExclusion Criteria:\n\n* Hearing loss with explicit causes, including noise-induced, Ménière's disease, ototoxicity exposure, mumps infection or history of syphilis infection and so on.\n* A history of head trauma or otologic surgery.\n* Malformation of temporal bone discovered by computed tomography (CT)\n* Retro-cochlear lesion discovered by magnetic resonance imaging (MRI)\n* Pregnant women",true,"ALL","4 Years","65 Years",{"count":34,"type":35},400,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL). The main problems it aims to deal with are:\n\n* if there is a difference in data of exome and targeted sequencing among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls\n* if there is a difference in the parameter of MRI among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls\n* to find out which factor from multi-omics data relates to outcomes of SSNHL\n* to develop the best prognostics model based on the multi-omics data.\n\nParticipants will be received audiological tests, blood specimen collection and radiological examination. Researchers will explore the relationship between the multi-omics data and the prognosis and develop the predictive model.",[39,40,41],"Sudden Sensorineural Hearing Loss","Hearing Loss, Sensorineural","Hearing Loss, Sudden","NOT_YET_RECRUITING","2024-04-09",{"date":45,"type":46},"2024-04-15","ACTUAL",{"date":48,"type":35},"2024-04-23",{"date":50,"type":35},"2026-11-23",{"name":20,"class":6}]