[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533038":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":98,"collaborators":101,"id":105,"slug":106,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":10,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":113,"minAge":114,"maxAge":10,"enrollmentInfo":115,"targetDuration":10,"studyType":118,"phases":10,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Zhejiang University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Case arm",null,"Prospective enrollment of participants confirmed with colorectal adenocarcinoma or advanced adenoma",{"label":13,"type":10,"description":14,"interventionNames":10},"Control arm","Prospective enrollment of healthy participants who have general risk or high risk of colorectal cancer",[16],{"name":17,"affiliation":18,"role":19},"Kefeng Ding, MD","Second Affiliated Hospital, School of Medicine, Zhejiang University","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","86-571-87784827","dingkefeng@zju.edu.cn",[26,43,54,65,76,87],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"The Second Affiliated Hospital of Zhejiang University","RECRUITING","Hangzhou","Zhejiang","31000","China","CN",{"type":35,"coordinates":36},"Point",[37,38],120.16142,30.29365,{"lat":38,"lon":37},[41,42],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"facility":44,"status":28,"city":45,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":46,"geoPoint":50,"contacts":51},"Sun Yat-Sen University Cancer Hospital","Guangzhou",{"type":35,"coordinates":47},[48,49],113.25,23.11667,{"lat":49,"lon":48},[52],{"name":53,"role":22,"phone":10,"phoneExt":10,"email":10},"Junzhong Lin, MD",{"facility":55,"status":28,"city":56,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Yunnan cancer hospital","Kunming",{"type":35,"coordinates":58},[59,60],102.71833,25.03889,{"lat":60,"lon":59},[63],{"name":64,"role":22,"phone":10,"phoneExt":10,"email":10},"Yunfeng Li, MD",{"facility":66,"status":28,"city":67,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Jiangsu province hospital","Nanjing",{"type":35,"coordinates":69},[70,71],118.77778,32.06167,{"lat":71,"lon":70},[74],{"name":75,"role":22,"phone":10,"phoneExt":10,"email":10},"Yanhong Gu, MD",{"facility":77,"status":28,"city":78,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"The first affiliated hospital of Xi'an Jiaotong University","Xi'an",{"type":35,"coordinates":80},[81,82],108.92861,34.25833,{"lat":82,"lon":81},[85],{"name":86,"role":22,"phone":10,"phoneExt":10,"email":10},"Xuejun Sun, MD",{"facility":88,"status":28,"city":89,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University","Zhengzhou",{"type":35,"coordinates":91},[92,93],113.64861,34.75778,{"lat":93,"lon":92},[96],{"name":97,"role":22,"phone":10,"phoneExt":10,"email":10},"Jing Zhuang, MD",{"type":19,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":18,"oldNameTitle":10,"oldOrganization":10},"Ding Ke-Feng","Chief physician",[102],{"name":103,"class":104},"New Horizon Health Technology Co., Ltd","UNKNOWN","100533038","multi-omics-study-for-early-detection-of-colorectal-cancer-moed-crc-100533038",false,"NCT06220617","Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)","Multi-omics Study for Early Detection of Colorectal Cancer Based on Liquid Biopsy Technology","Inclusion Criteria for Case Arm:\n\n1. Aged over 18 years.\n2. Participants confirmed with colorectal adenocarcinoma or advanced adenoma through colonoscopy and pathological examination.\n3. Provision of informed consent prior to any study specific procedures, sampling, and analyses.\n\nInclusion Criteria for Control Arm:\n\n1. Individuals of \"General risk arm\" should meet all the following criteria:\n\n   1. No history of colorectal adenomas or sessile serrated polyps.\n   2. No history of inflammatory bowel disease (8-10 years ).\n   3. No family history (first-degree relatives) of colorectal cancer.\n2. Individuals of \"High-risk arm\" should meet at least one of the following criteria:\n\n   1. Asia-Pacific Colorectal Screening (APC) score ≥ 3.\n   2. Family history (first-degree relatives) of colorectal cancer.\n   3. History of positive fecal occult blood test.\n   4. Any 2 of the following: chronic diarrhea, chronic constipation, mucous bloody stools, history of psychological stimulation, history of chronic appendicitis or appendectomy, history of chronic biliary disease or cholecystectomy.\n   5. Individuals with inflammatory bowel disease.\n3. All participants must be confirmed not to have colorectal malignancy or advanced adenomas through colonoscopy.\n4. Provision of informed consent prior to any study specific procedures, sampling, and analyses.\n\nExclusion Criteria:\n\n1. History of other malignant tumors (excluding non-melanoma skin cancer).\n2. Prior or related treatments previously (including colorectal cancer or advanced adenoma surgery, endoscopic treatment, chemotherapy, targeted therapy, immunotherapy, radiation, neoadjuvant therapy, etc.).\n3. Patients with hereditary colorectal diseases (including Lynch syndrome, familial CRC type X (FCCX), familial adenomatous polyposis (FAP), MUTHY-associated polyposis (MAP), Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS), serrated polyposis syndrome (SPS), etc.).\n4. Usage of anti-tumor drugs such as methotrexate, cyclophosphamide, mercaptopurine, and bendamustine for other diseases within 30 days before blood collection.\n5. Prior blood transfusion (including blood components) within the past 2 weeks.\n6. Prior organ transplantation, bone marrow transplantation, or stem cell transplantation.\n7. Pregnancy women.\n8. Prior or current anti-infection treatment within 14 days before blood collection.\n9. Inability to comply with study procedures such as blood collection and related examinations.\n10. Deemed unsuitable for participation in the clinical trial by the investigator.",true,"ALL","18 Years",{"count":116,"type":117},3600,"ESTIMATED","OBSERVATIONAL","The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical performance externally.",[121,122,123,124],"Colorectal Cancer","Adenomatous Polyps","Adenoma","Advanced Adenoma",[121,126,122,123,127],"Colorectal Neoplasms","Advanced adenoma","2024-01-28",{"date":130,"type":131},"2024-01-30","ACTUAL",{"date":133,"type":131},"2024-01-11",{"date":135,"type":117},"2027-06-30",{"name":5,"class":6},6]