[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545081":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":45,"responsibleParty":88,"collaborators":91,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":25,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"University of Nottingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inactivity","EXPERIMENTAL","Participants in this group will reduce their physical activity (increase sitting time to 7hrs\u002Fday and decrease step count to \\\u003C4500\u002Fday) for 3 months, then increase their activity for 3 months, through attending 3x 45 min supervised exercise sessions\u002Fweek.",[13],"Behavioral: Decreased Physical Activity",{"label":15,"type":10,"description":16,"interventionNames":17},"Activity","Participants in this group will have moderate intensity physical activity levels increased for 6 months, through attending 3x 45 min supervised exercise sessions\u002Fweek.",[18],"Behavioral: Increased Physical activity",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Decreased Physical Activity","Physical activity levels will be decreased",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Increased Physical activity","Physical activity levels will be increased",[15],[31],{"name":32,"affiliation":5,"role":33},"Paul L Greenhaff, PhD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Paul L Greenhaff (PI), PhD","CONTACT","+44 (0) 1158230133","paul.greenhaff@nottingham.ac.uk",{"name":41,"role":37,"phone":42,"phoneExt":43,"email":44},"Melanie Tooley (participant recruitment), BSc","+44 (0) 115 9515151","19105","melanie.marshall@nottingham.ac.uk",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"David Greenfield Human Physiology Unit","RECRUITING","Nottingham","Notts","NG72UH","United Kingdom","UK",{"type":55,"coordinates":56},"Point",[57,58],-1.15047,52.9536,{"lat":58,"lon":57},[61,65,69,71,74,75,77,79,81,83,84,86],{"name":62,"role":37,"phone":63,"phoneExt":25,"email":64},"Sara Brown","+44(0)115 8230434","sara.brown@nottingham.ac.uk",{"name":66,"role":37,"phone":67,"phoneExt":25,"email":68},"Joanne Mallinson, PhD","+44(0)1158230434","joanne.mallinson@nottingham.ac.uk",{"name":70,"role":33,"phone":25,"phoneExt":25,"email":25},"Paul Greenhaff, PhD",{"name":72,"role":73,"phone":25,"phoneExt":25,"email":25},"Liz Simpson, PhD","SUB_INVESTIGATOR",{"name":66,"role":73,"phone":25,"phoneExt":25,"email":25},{"name":76,"role":73,"phone":25,"phoneExt":25,"email":25},"Abhishek Sheth, MD",{"name":78,"role":73,"phone":25,"phoneExt":25,"email":25},"Penny Gowland, PhD",{"name":80,"role":73,"phone":25,"phoneExt":25,"email":25},"Sue Francis, PhD",{"name":82,"role":73,"phone":25,"phoneExt":25,"email":25},"Rosemary Nicholls, PhD",{"name":62,"role":73,"phone":25,"phoneExt":25,"email":25},{"name":85,"role":73,"phone":25,"phoneExt":25,"email":25},"Donald Peden, PhD",{"name":87,"role":73,"phone":25,"phoneExt":25,"email":25},"Alena Ponitzova",{"type":33,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Paul Greenhaff","Principal Investigator",[92],{"name":93,"class":6},"Biotechnology and Biological Sciences Research Council","100545081","multi-organ-responses-to-chronic-physical-activity-and-inactivity-100545081",false,"NCT06377254","Multi-organ Responses to CHronic Physical Activity and INactivity","Concurrent Multi-organ Responses to CHronic Physical Activity and INactivity Intervention, to Increase Research Discovery in Human Health and Wellbeing","CHAIN","Inclusion Criteria:\n\n* Group 1 ('non-sedentary') self-reporting \\\u003C6 sedentary hrs\u002Fday, not actively involved in exercise training or a regular physical activity regimen (\\>8,000 steps\u002Fday).\n* Group 2 ('sedentary') self-reporting ≥8 waking hrs\u002Fday in sedentary activities and\u002For ≤5,000 steps\u002Fday.\n* Aged 50-65y.\n* Overweight (BMI 25-35 kg\u002Fm2).\n* Waist circumference ≥94cm (males) and ≥80cm (females).\n* Willing to alter physical activity levels as instructed for 6 months\n* Without neurological or psychiatric diseases, motor or cognitive restrictions\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* Regular medication use that could interfere with measures\n* A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.\n* Experiencing 'long-COVID', inflammatory bowel disease or malignancy.\n* Uncontrolled hypertension. Stage 1 hypertension (BP ≤160\u002F100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion.\n* People employed in jobs that would preclude reducing step count and night-shift workers.\n* Females who are pre\u002Fperi-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible.\n* Contraindications for MRI.\n* Allergy or sensitivity to local anaesthesia, or dressing adhesive",true,"ALL","50 Years","65 Years",{"count":107,"type":108},40,"ESTIMATED","INTERVENTIONAL",[111],"NA","Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual.\n\nPersistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend \\>8hrs\u002Fday being sedentary, with average step count of 3000-4000 steps\u002Fday.\n\nTo be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characterised.\n\nThe goal of this intervention study is to compare the impact of physical activity and inactivity on body functioning. Twenty moderately active participants will decrease their physical activity for three months to match the average amount carried out by middle-aged people in the UK. They will then undertake 3-months of reconditioning training to restore their fitness. In addition, twenty sedentary participants will increase their physical activity to UK recommended levels for six months.\n\nBefore and at points during the intervention period, participants will be asked to make some measurements at home and attend the University of Nottingham to have multiple assessments made. These include;\n\n* fitness, muscle strength and function tests,\n* completion of questionnaires and computer-based brain puzzles\n* having muscle and fat tissue biopsies and blood samples taken.\n* The study also involves having MRI scans.\n\nThis 5-year study will commence in January 2024, with participant recruitment starting in March 2024 and finishing in May 2027.",[114,115,116,117],"Sedentary Behavior","Metabolic Syndrome","Age-related Cognitive Decline","Age-Related Sarcopenia",[119,120,121,122,123],"Physical activity","middle-age","Physical inactivity","overweight","lifestyle","2025-11-26",{"date":126,"type":127},"2025-12-04","ACTUAL",{"date":129,"type":127},"2024-03-12",{"date":131,"type":108},"2028-10-31",{"name":5,"class":6},1]