[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635930":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":11,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":11,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TBS intervention targeting multiple targets (L-DLPFC, L-IPL, R-OFC)","ACTIVE_COMPARATOR",null,[13],"Device: repetitive transcranial magnetic stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","SHAM_COMPARATOR","Same targets, same TBS parameters, coil rotated 180°",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","repetitive transcranial magnetic stimulation (rTMS)","Repetitive transcranial magnetic stimulation (rTMS) is a recently developed neuromodulation technique.",[15,9],[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"Huiru Cui, Ph.D","CONTACT","+86 21 34773230","cuihuiru@163.com",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Shanghai","Shanghai Municipality","200030","China","CN",{"type":40,"coordinates":41},"Point",[42,43],121.45806,31.22222,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":48,"phoneExt":11,"email":30},"Huiru Cui","86 21 34773230",{"type":50,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100635930","multi-target-tms-for-schizophrenia-negative-symptoms-100635930",false,"NCT07559084","Multi-target TMS for Schizophrenia Negative Symptoms","Development of a Multi-target Transcranial Magnetic Intervention Technique for Negative Symptoms of Schizophrenia","Inclusion Criteria:\n\n1. Outpatients or inpatients at the Department of Psychiatry, Shanghai Mental Health Center;\n2. Meet the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for first-episode schizophrenia (diagnosed using the Structured Clinical Interview for DSM-5, SCID-5); disease duration less than 5 years at enrollment;\n3. Male or female aged 16-45 years;\n4. Education duration ≥ 9 years;\n5. Stable medication regimen for at least 6 weeks prior to baseline visit and throughout the study period; psychiatric symptoms generally stable within 1 month prior to baseline visit;\n6. Participants and their guardians can understand and sign written informed consent;\n7. Total score on the PANSS Negative Symptom subscale (PANSS-N) \\> 15, and at least one item score ≥ 3.\n\nExclusion Criteria:\n\n1. Current or lifetime psychiatric disorders as determined by SCID-5 assessment;\n2. Severe or unstable physical illnesses, including: neurological disorders (delirium, dementia, stroke, epilepsy, migraine, etc.), congestive heart failure, angina pectoris, myocardial infarction, arrhythmia, hypertension, hyperglycemia, malignant tumors, and immunocompromised conditions;\n3. Alcohol abuse within 30 days prior to the study or alcohol\u002Fdrug dependence within 6 months prior to the study; participation in any clinical trial within 30 days prior to baseline;\n4. Pregnant or breastfeeding women;\n5. Intellectual disability (IQ \\\u003C 70).","ALL","16 Years","45 Years",{"count":62,"type":63},64,"ESTIMATED","INTERVENTIONAL",[66],"NA","This randomized controlled trial (RCT) is the first to evaluate the efficacy and safety of a multi-target TMS protocol targeting the left dorsolateral prefrontal cortex (L-DLPFC), left inferior parietal lobule (L-IPL), and right orbitofrontal cortex (R-OFC) for negative symptoms of schizophrenia.",[69],"SCHIZOPHRENIA 1 (Disorder)",[71,72,73,74,75],"schizophrenia","TMS","repetitive transcranial magnetic stimulation","rTMS","TBS","2026-04-26",{"date":78,"type":79},"2026-04-30","ACTUAL",{"date":81,"type":63},"2026-05-01",{"date":83,"type":63},"2028-01-30",{"name":5,"class":6},1]