[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549495":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":44,"locations":53,"responsibleParty":125,"collaborators":127,"id":134,"slug":135,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":136,"sex":142,"minAge":143,"maxAge":144,"enrollmentInfo":145,"targetDuration":26,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham stimulation","SHAM_COMPARATOR","A sham coil with exactly the same appearance of active coil is used to compare with active coil. Stimulation dose and frequency is the same as active stimulation.",[13],"Device: sham stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Active stimulation","ACTIVE_COMPARATOR","An active coil is used to deliver iTBS. The stimulation dose is 20 sessions (1800 pulses per session; 2 sessions a day, at least 1 hour apart) over the course of 2 weeks (10 days to 14 days, allow at most three breaks and only once of the longest interval of 2 days).",[19],"Device: intermittent theta-burst stimulation (iTBS)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","sham stimulation","sham theta-burst transcranial magnetic stimulation",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"intermittent theta-burst stimulation (iTBS)","intermittent theta-burst transcranial magnetic stimulation",[15],[32,36,39,42],{"name":33,"affiliation":34,"role":35},"Yuan Shen, M.D., Ph.D.","Shanghai Mental Health Center","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":35},"Chang Yu, M.D.","The Affiliated Kangning Hospital of Ningbo University",{"name":40,"affiliation":41,"role":35},"Kai Wang, M.D., Ph.D.","The First Affiliated Hospital of Anhui Medical University",{"name":43,"affiliation":5,"role":35},"Xiaoming Li, M.D., Ph.D.",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":26,"email":49},"Huiqian Huang, Ph.D.","CONTACT","+8618757143725","hhq0301@zju.edu.cn",{"name":51,"role":47,"phone":26,"phoneExt":26,"email":52},"Shanshan Li, Bachelor","1252037349@qq.com",[54,72,87,101,114],{"facility":34,"status":55,"city":56,"state":57,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Shanghai","Shanghai Municipality","China","CN",{"type":61,"coordinates":62},"Point",[63,64],121.45806,31.22222,{"lat":64,"lon":63},[67,71],{"name":68,"role":47,"phone":69,"phoneExt":26,"email":70},"Zhongyong Shi, M.D., Ph.D.","+8618701915271","szy0721@126.com",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":73,"status":55,"city":74,"state":75,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"First Affiliated Hospital of Anhui Medical University","Hangzhou","Zhejiang",{"type":61,"coordinates":77},[78,79],120.16142,30.29365,{"lat":79,"lon":78},[82,86],{"name":83,"role":47,"phone":84,"phoneExt":26,"email":85},"Gongjun Ji, Ph.D.","+86055165167581","jigongjun@163.com",{"name":40,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":88,"status":55,"city":74,"state":75,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"Second Affiliated Hospital Zhejiang University School of Medicine",{"type":61,"coordinates":90},[78,79],{"lat":79,"lon":78},[93,95,97,99],{"name":46,"role":47,"phone":94,"phoneExt":26,"email":49},"(+86)057188206092",{"name":51,"role":47,"phone":96,"phoneExt":26,"email":52},"+8615867111248",{"name":98,"role":35,"phone":26,"phoneExt":26,"email":26},"Xiao-Ming Li, Ph.D., M.D.",{"name":46,"role":100,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"facility":38,"status":55,"city":102,"state":75,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Ningbo",{"type":61,"coordinates":104},[105,106],121.54945,29.87819,{"lat":106,"lon":105},[109,113],{"name":110,"role":47,"phone":111,"phoneExt":26,"email":112},"Wenhao Zhuang, M.D.","+8615888178517","zwhphil@163.com",{"name":37,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":115,"status":55,"city":56,"state":26,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":116,"geoPoint":118,"contacts":119},"Tongji Hospital of Tongji University",{"type":61,"coordinates":117},[63,64],{"lat":64,"lon":63},[120,124],{"name":121,"role":47,"phone":122,"phoneExt":26,"email":123},"Xinchun Mei","021-51030581","xinchun0416@163.com",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":126,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[128,129,131,132],{"name":34,"class":6},{"name":38,"class":130},"UNKNOWN",{"name":41,"class":6},{"name":133,"class":6},"Tongji Hospital","100549495","multicenter-itbs-neuromodulation-for-ptsd-treatment-100549495",false,"NCT06434766","Multicenter iTBS Neuromodulation for PTSD Treatment","A Multicenter Clinical Study on Transcranial Magnetic Stimulation of the Primary Motor Cortex for PTSD Treatment","TMCP","Inclusion Criteria:\n\n* Aged between 18 to 65 years old\n* Right handedness\n* Have a diagnosis of PTSD meeting DSM-5 criteria\n* CAPS-5 score\\>35\n* Under stable medication for at least four weeks\n* Capable of independently reading and understanding study materials and providing informed consent.\n\nExclusion Criteria:\n\n* Current (or past if appropriate) significant neurological or medical disorder, or lifetime history of 1) seizure disorder; 2) primary or secondary CNS tumors; 3) stroke; or 4) cerebral aneurysm.\n* Primary psychotic disorder, bipolar I disorder, major depressive disorder, or personality disorders\n* Lifetime history of attempted suicide or HAMD-17 suicide item (item 3) ≥ 3 points\n* Implanted device (deep brain stimulation) or metal in the brain; a pacemaker, extensive dental work, or any magnetic metal implants and upper body tattoos if choose to do fMRI\n* Previous experience of rTMS\n* Pregnancy\u002Flactation, or planning to become pregnant during the study\n* Current under psychological or other physical treatments","ALL","18 Years","65 Years",{"count":146,"type":147},140,"ESTIMATED","INTERVENTIONAL",[150],"NA","The proposed study aims to evaluate the efficacy of intermittent theta-burst transcranial magnetic stimulation (iTBS) targeting primary motor cortex (M1) as adjunct treatment for PTSD patients. The primary outcome measure includes changes in PTSD symptom severity, with secondary outcome measures focusing on negative moods improvements, quality of life and social\u002Foccupation functioning and functional connectivity of the brain.",[153],"Posttraumatic Stress Disorder",[155,156],"iTBS","PTSD","2026-04-21",{"date":159,"type":160},"2026-04-24","ACTUAL",{"date":162,"type":160},"2024-10-30",{"date":164,"type":147},"2027-06",{"name":5,"class":6},5]