[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616487":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":33,"responsibleParty":97,"collaborators":99,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":117,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":18,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":136,"whyStopped":18,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ALA-PDT Group","EXPERIMENTAL","ALA-PDT administered every 7-14 days for a total of 3-6 sessions.",[13],"Procedure: ALA-PDT",{"label":15,"type":16,"description":17,"interventionNames":18},"Observation Group","NO_INTERVENTION","Observation and follow-up",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","ALA-PDT","Photosensitizer is applied to the cervical canal and cervix, followed by light irradiation, repeated every 7-14 days for 3-6 sessions.",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Xiaoyun Wang, Doctor","CONTACT","+86 0571-87783759","doctorwangxy@zju.edu.cn",{"name":32,"role":28,"phone":18,"phoneExt":18,"email":18},"Jianwei Zhou, Professor",[34,52,61,71,84],{"facility":35,"status":18,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Women's Hospital School Of Medicine Zhejiang University","Hangzhou","Zhejiang","310000","China","CN",{"type":42,"coordinates":43},"Point",[44,45],120.16142,30.29365,{"lat":45,"lon":44},[48],{"name":49,"role":28,"phone":50,"phoneExt":18,"email":51},"Ying Li, Doctor","13705815380","17550215@qq.com",{"facility":53,"status":18,"city":36,"state":37,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":54,"geoPoint":56,"contacts":57},"First People's Hospital of Hangzhou",{"type":42,"coordinates":55},[44,45],{"lat":45,"lon":44},[58],{"name":59,"role":28,"phone":60,"phoneExt":18,"email":18},"Hongkai Shang, Doctor","15990032799",{"facility":62,"status":18,"city":36,"state":37,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"Hangzhou Linping District first People's Hospital",{"type":42,"coordinates":64},[44,45],{"lat":45,"lon":44},[67],{"name":68,"role":28,"phone":69,"phoneExt":18,"email":70},"Lifang You, Doctor","18958174527","y20042668@sina.com",{"facility":72,"status":18,"city":73,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"First Affiliated Hospital of Ningbo University","Ningbo",{"type":42,"coordinates":75},[76,77],121.54945,29.87819,{"lat":77,"lon":76},[80],{"name":81,"role":28,"phone":82,"phoneExt":18,"email":83},"Juanjuan Shi, Doctor","138 8449 6502","bessalice0707@163.com",{"facility":85,"status":18,"city":86,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Shaoxing People's Hospital","Shaoxing",{"type":42,"coordinates":88},[89,90],120.57864,30.00237,{"lat":90,"lon":89},[93],{"name":94,"role":28,"phone":95,"phoneExt":18,"email":96},"Huaqin Pang","13625757126","hqpang@163.com",{"type":98,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[100,101,102,104,105],{"name":35,"class":6},{"name":53,"class":6},{"name":72,"class":103},"NETWORK",{"name":85,"class":6},{"name":106,"class":107},"Linping First People's Hospital","UNKNOWN","100616487","multicenter-prospective-non-randomized-controlled-study-of-ala-pdt-for-lsil-with-hpv1618-infection-100616487",false,"NCT07306247","Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16\u002F18 Infection","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical Low-grade Squamous Intraepithelial Lesions With HPV16\u002F18 Infection","PDT for LSIL","Inclusion Criteria:\n\n1. Female, 20-60 years, understands study procedures and consents to participate;\n2. HPV 16 or 18 positive;\n3. Colposcopy-guided cervical biopsy within 3 months showing LSIL;\n4. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","20 Years","60 Years",{"count":121,"type":122},225,"ESTIMATED","INTERVENTIONAL",[125],"NA","This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16\u002F18 infection.",[128,129,130],"HPV-16\u002F18","Photodynamic Therapy (PDT)","LSIL, Low Grade Squamous Intraepithelial Lesion",[132,133,134,135],"cervical low-grade squamous intraepithelial lesions","aminolevulinic acid-mediated photodynamic therapy","efficacy","human papillomavirus","NOT_YET_RECRUITING","2025-12-14",{"date":139,"type":140},"2025-12-29","ACTUAL",{"date":142,"type":122},"2026-01",{"date":144,"type":122},"2027-12",{"name":5,"class":6},5]